Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-acetoxymethyl-7-[S]-methoxy-8-oxo-5-thia-1-aza-6[R]-bicyclo[4.2.0]oct-2-ene-2-(2-(S)-carboxypyrrolidine-carboxamide)-5,5-dioxide | L-658,758, cephalosporin-based anti-elastase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha1-PI + H2O | Homo sapiens | important antiprotease of the lung, enzyme reduces the lungs primary protection against proteolysis | ? | - |
? | |
Elastin + H2O | Homo sapiens | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | ? | protein cleaved at at least one location | ? | |
SLPI + H2O | Homo sapiens | important antiprotease of the lung, enzyme reduces the lungs primary protection against proteolysis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with cystic fibrosis | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Homo sapiens | - |
sputum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha1-PI + H2O | important antiprotease of the lung, enzyme reduces the lungs primary protection against proteolysis | Homo sapiens | ? | - |
? | |
Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | Homo sapiens | ? | protein cleaved at at least one location | ? | |
methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O | - |
Homo sapiens | methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline | - |
? | |
Protein + H2O | enzyme capable of degrading proteins of the lung extracellular matrix in vitro | Homo sapiens | ? | - |
? | |
SLPI + H2O | important antiprotease of the lung, enzyme reduces the lungs primary protection against proteolysis | Homo sapiens | ? | - |
? |