Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | Homo sapiens | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | ? | protein cleaved at at least one location | ? | |
IgA + H2O | Homo sapiens | involved in the regulation of inflammation by a feedback mechanism, elastase treated IgA preparations are unable to induce oxidative burst of polymorphonuclear leukocytes | ? | protein cleaved in the hinge region | ? | |
IgG + H2O | Homo sapiens | involved in the regulation of inflammation by a feedback mechanism, elastase treated IgG preparations are unable to induce oxidative burst of polymorphonuclear leukocytes | ? | protein cleaved in the hinge region | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
cystic fibrosis patients suffering from chronic Pseudomonas aeruginosa lung infection | - |
Purification (Comment) | Organism |
---|---|
from pooled sputum | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukocyte | polymorphonuclear leukocytes | Homo sapiens | - |
lung | - |
Homo sapiens | - |
sputum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
Elastin + H2O | involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged | Homo sapiens | ? | protein cleaved at at least one location | ? | |
IgA + H2O | involved in the regulation of inflammation by a feedback mechanism, elastase treated IgA preparations are unable to induce oxidative burst of polymorphonuclear leukocytes | Homo sapiens | ? | protein cleaved in the hinge region | ? | |
IgG + H2O | involved in the regulation of inflammation by a feedback mechanism, elastase treated IgG preparations are unable to induce oxidative burst of polymorphonuclear leukocytes | Homo sapiens | ? | protein cleaved in the hinge region | ? |
Subunits | Comment | Organism |
---|---|---|
? | x * 25000-30000, SDS-PAGE | Homo sapiens |