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Literature summary for 3.4.21.37 extracted from

  • Doring, G.; Goldstein, W.; Botzenhart, K.; Kharazmi, A.; Schiotz, P.O.; Hoiby, N.; Dasgupta, M.
    Elastase from polymorphonuclear leucocytes: a regulatory enzyme in immune complex disease (1986), Clin. Exp. Immunol., 64, 597-605.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged ? protein cleaved at at least one location ?
IgA + H2O Homo sapiens involved in the regulation of inflammation by a feedback mechanism, elastase treated IgA preparations are unable to induce oxidative burst of polymorphonuclear leukocytes ? protein cleaved in the hinge region ?
IgG + H2O Homo sapiens involved in the regulation of inflammation by a feedback mechanism, elastase treated IgG preparations are unable to induce oxidative burst of polymorphonuclear leukocytes ? protein cleaved in the hinge region ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
cystic fibrosis patients suffering from chronic Pseudomonas aeruginosa lung infection
-

Purification (Commentary)

Purification (Comment) Organism
from pooled sputum Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte polymorphonuclear leukocytes Homo sapiens
-
lung
-
Homo sapiens
-
sputum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
Homo sapiens ?
-
?
Elastin + H2O involved in lung defense against bacterial infection, due to the ability of the enzyme to cleave cell surface proteins, body cells might also be damaged Homo sapiens ? protein cleaved at at least one location ?
IgA + H2O involved in the regulation of inflammation by a feedback mechanism, elastase treated IgA preparations are unable to induce oxidative burst of polymorphonuclear leukocytes Homo sapiens ? protein cleaved in the hinge region ?
IgG + H2O involved in the regulation of inflammation by a feedback mechanism, elastase treated IgG preparations are unable to induce oxidative burst of polymorphonuclear leukocytes Homo sapiens ? protein cleaved in the hinge region ?

Subunits

Subunits Comment Organism
? x * 25000-30000, SDS-PAGE Homo sapiens