Information on EC 2.7.7.48 - RNA-directed RNA polymerase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.7.48
-
RECOMMENDED NAME
GeneOntology No.
RNA-directed RNA polymerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
nucleoside triphosphate + RNAn = diphosphate + RNAn+1
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.
CAS REGISTRY NUMBER
COMMENTARY hide
9026-28-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
i.e. AaV-1, isolated from the mycelia of EGS 35-193 strain of Alternaria alternata
-
-
Manually annotated by BRENDA team
Drosophila melanogaster infected with
-
-
Manually annotated by BRENDA team
i.e. BlVS, from Rubus canadensis berris, the virus might belong to the family Tymoviridae
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Hordeum vulgare leaf infected with
-
-
Manually annotated by BRENDA team
Caenorhabditis elegans Bristol N2
strain Bristol N2, gene rrf-3
-
-
Manually annotated by BRENDA team
i.e. CsfrRNAV, from the cytosol of axenic clonal algal strain L-4 of the bloom-forming Chaetoceros socialis f. radians, isolated from surface water at the Itsukaichi fishing port in Hiroshima Bay, Japan
UniProt
Manually annotated by BRENDA team
i.e. ORMV, a tobamovirus taxonomically distinct from the type member of the genus, cultivated on Nicotiana benthamiana and Nicotiana tabacum plants
-
-
Manually annotated by BRENDA team
expression in Escherichia coli
-
-
Manually annotated by BRENDA team
cowpea leaf infected with
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Coxsackievirus B3 Nancy
strain Nancy
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
viral polyprotein
UniProt
Manually annotated by BRENDA team
DENV
-
-
Manually annotated by BRENDA team
-
GenBank
Manually annotated by BRENDA team
-
GenBank
Manually annotated by BRENDA team
BHK-21 cells infected with
-
-
Manually annotated by BRENDA team
Escherichia coli infected with
-
-
Manually annotated by BRENDA team
Qbetaam12
-
-
Manually annotated by BRENDA team
QbetaamB86
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
i.e. FHV
-
-
Manually annotated by BRENDA team
Foxtail mosaic potexvirus
Chenopodium guinoa infected with
-
-
Manually annotated by BRENDA team
i.e. FgV3, a dsRNA mycovirus from Fusarium graminearum strain DK3
UniProt
Manually annotated by BRENDA team
i.e. FgV4, a dsRNA mycovirus from Fusarium graminearum strain DK4
UniProt
Manually annotated by BRENDA team
i.e. GLRaV-Pr, an isolate from Greek grapevines, Vitis vinifera cv. Mantilaria, belongs to the Ampelovirus group
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
NS5B
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
i.e. HSV-1
-
-
Manually annotated by BRENDA team
human parainfluenza virus
-
-
-
Manually annotated by BRENDA team
influenza A virus Victoria/3/1975 H3N2
subunit P2; Victoria/3/1975, H3N2
UniProt
Manually annotated by BRENDA team
Influenza virus A/PR8
-
-
-
Manually annotated by BRENDA team
i.e. IYSV, belongs to the genus Tospovirus, family Bunyaviridae, transmitted by onion thrips, Thrips tabaci
UniProt
Manually annotated by BRENDA team
strain JaOH0566
-
-
Manually annotated by BRENDA team
JEV
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-
Manually annotated by BRENDA team
strain MRM61C, Vero cells infected with
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-
Manually annotated by BRENDA team
Kunjin virus MRM61C
strain MRM61C, Vero cells infected with
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-
Manually annotated by BRENDA team
La France isometric virus
Agaricus bisporus infected with
-
-
Manually annotated by BRENDA team
Zea mays infected with
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-
Manually annotated by BRENDA team
strain Alaska
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
i.e. MNV-1
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-
Manually annotated by BRENDA team
group I RDR
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
GenBank
Manually annotated by BRENDA team
i.e. PiRV-1, isolates MX980400 and MX980317
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Manually annotated by BRENDA team
dsR1; i.e. PmV1, belongs to the genus Partitivirus, a plant-associated virus
UniProt
Manually annotated by BRENDA team
Respiratory Enteric Orphan Virus type-1, Reo-1
-
-
Manually annotated by BRENDA team
P2a-P2b fusion protein forming the viral RNA replicase; i.e. RuCMV, a sobemovirus, isolated from raspberry and bramble plants in north east Scotland
UniProt
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
SA11 Rotavirus
-
-
Manually annotated by BRENDA team
-
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Manually annotated by BRENDA team
SLEV
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Manually annotated by BRENDA team
i.e. TSV, isolated from tail muscle tissue of infected shrimp from shrimp farms in Texas in 2004, a member of the family Dicistroviridae
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Manually annotated by BRENDA team
i.e. TMV, is a type member of the tobamovirus family, clone TMV-KK1, cultivated on Nicotiana benthamiana and Nicotiana tabacum plants
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Manually annotated by BRENDA team
Nicotiana tabacum plant infected with
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Manually annotated by BRENDA team
infected with Cowpea mosaic virus. The host-encoded enzyme is strongly stimulated upon CPMV infection of cowpea leaves
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Manually annotated by BRENDA team
viral polyprotein
UniProt
Manually annotated by BRENDA team
WNV
Uniprot
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(dT)12 + UTP
diphosphate + ?
show the reaction diagram
-
assay uses poly(A) as an RNA template and oligo(dT)12-18 as the primer. Enzyme is strictly dependent on the presence of primer
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-
?
5-fluorouridine triphosphate + RNAn
diphosphate + RNAn+1
show the reaction diagram
-
the enzyme incorporates 5-fluorouridine monophosphate during RNA elongation in place of UMP or CMP using homopolymeric and heteropolymeric templates. Incorporation of 5-fluorouridine monophosphate does not prevent chain elongation, and, in some sequence contexts, it favors misincorporations at downstream positions. 5-Fluorouridine monophosphate is incorporated into the nascent RNA and occupies the new 3'-end of the primer at the active site of the enzyme. 5-Fluorouridine monophosphate establishes a Watson and Crick pair with the corresponding acceptor AMP in the template strand and an additional hydrogen bond with Ser304 of the polymerase. Further interactions, similar to those observed with standard nucleotides, contribute also to stabilize 5-fluorouridine monophosphate in the 3'-terminus of the RNA. When present in the template, 5-fluorouridine monophosphate directs the incorporation of AMP and GMP, with ATP being a more effective substrate than GTP. The misincorporation of GMP is 17fold faster opposite 5-fluorouridine than opposite U in the template. But Incorporated 5-fluorouridine monophosphate is not a chain terminator during RNA elongation
RNA with incoporated 5-fluorouridine phosphate
-
?
CTP + RNA9
diphosphate + RNA10
show the reaction diagram
AJ242654
-
-
-
?
GTP + poly(C)
diphosphate + ?
show the reaction diagram
nucleoside triphosphate + RNAn
diphosphate + RNAn+1
show the reaction diagram
ribavirin triphosphate + RNAn
?
show the reaction diagram
ribavirin is a guanosine analogue that can be a substrate for the viral RNA polymerase. HCV is genetically variable, and this genetic variation can affect the polymerase's use of ribavirin triphosphate, overview
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-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
nucleoside triphosphate + RNAn
diphosphate + RNAn+1
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
divalent cation required, Ca2+ shows about 20% of the activity with Mg2+ at about 1 mM
NH4Cl
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activity is increased by a factor of about 1.2-1.5 when the final salt concentration is raised to 60 mM by the addition of NaCl, KCl or NH4Cl
Zn
structure reveals the presence of two zinc ion binding motifs
additional information
-
no detectable level of RdRp activity is observed in the presence of 0.5 to 10 mM Mg2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R)-6-bromo-N-[(1S)-1-phenylethyl]-2,3,4,9-tetrahydro-1H-carbazol-1-amine
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-
(1S)-1-(4-aminofuro[3,2-d]pyrimidin-7-yl)-1,4-anhydro-2-C-methyl-D-ribitol
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-
(1S)-1-(4-aminothieno[3,2-d]pyrimidin-7-yl)-1,4-anhydro-2-C-methyl-D-ribitol
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-
(2E)-3-(4-[[(1-[[(1-cyclohexyl-2-furan-3-yl-1H-benzimidazol-5-yl)carbonyl]amino]cyclobutyl)carbonyl]amino]phenyl)prop-2-enoic acid
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-
(2E)-3-(4-[[(2-cyclohexyl-3-phenylquinoxalin-6-yl)carbonyl]amino]phenyl)prop-2-enoic acid
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-
(2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
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-
(2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclopentyl]carbonyl]amino)phenyl]prop-2-enoic acid
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(2E)-3-[4-([[1-([[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
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-
(2E)-3-[4-([[1-([[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
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(2E)-3-[4-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoic acid
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-
(2E)-3-[4-([[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoic acid
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-
(2E)-3-[4-([[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoic acid
-
-
(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-azido-2-[[(2-methylpropanoyl)oxy]methyl]tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)
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(2R,3S,5S)-5-(methoxycarbonyl)-5-(2-methylpropyl)-2-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]pyrrolidine-3-carboxylic acid
-
-
(2R,3S,5S)-5-[(aminooxy)carbonyl]-5-(2-methylpropyl)-2-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]pyrrolidine-3-carboxylic acid
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-
(2S)-(((5Z)-5-[(5-ethyl-2-furyl)methylene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino)(4-fluorophenyl)acetic acid
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-
(2S)-1-[(2-amino-4-chloro-5-methylphenyl)sulfonyl]pyrrolidine-2-carboxylic acid
-
-
(2S)-1-[(3,4,5-trichloro-2-hydroxyphenyl)sulfonyl]pyrrolidine-2-carboxylic acid
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(2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pyrrolidine-2-carboxylic acid
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(2S)-1-[[4-([[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl]amino)phenyl]sulfonyl]pyrrolidine-2-carboxylic acid
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-
(2S)-2-[(2,4-dichlorobenzoyl)(3-nitrobenzyl)amino]-3-phenylpropanoic acid
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-
(2S,4S,5R)-1-[(4-tert-butylphenyl)carbonyl]-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid
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-
(2S,4S,5R)-1-[(4-tert-butylphenyl)carbonyl]-2-(2-methylpropyl)-5-thiophen-2-ylpyrrolidine-2,4-dicarboxylic acid
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(2S,4S,5R)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-1-[[4-(trifluoromethyl)phenyl]carbonyl]pyrrolidine-2,4-dicarboxylic acid
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-
(2S,4S,5R)-2-(2-methylpropyl)-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]pyrrolidine-2,4-dicarboxylic acid
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(2S,4S,5R)-2-isobutyl-4-(2-phenylacetyl)-5-(thiophen-2-yl)-1-(4-(trifluoromethyl)benzoyl)pyrrolidine-2-carboxylic acid
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(2S,4S,5R)-2-isobutyl-5-(thiophen-2-yl)-1-(4-(trifluoromethyl)benzoyl)pyrrolidine-2,4-dicarboxylic acid
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(2S,4S,5R)-4-acetyl-2-isobutyl-5-(thiophen-2-yl)-1-(4-(trifluoromethyl)benzoyl)pyrrolidine-2-carboxylic acid
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(2S,5R)-1-[(4-tert-butylphenyl)carbonyl]-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrole-2,4-dicarboxylic acid
-
-
(2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid
-
-
(2Z)-2-(benzoylamino)-3-[4-(2-bromophenoxy)phenyl]acrylic acid
-
-
(2Z)-3-[4-([[1-([[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
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(2Z)-3-[4-([[1-([[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
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-
(4R,5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-(ethoxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4R,5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-(hydroxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(3-bromo-4-tert-butylphenyl)carbonyl]-4-carbamoyl-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
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(4S,5R)-1-[(4-tert-butyl-3-chlorophenyl)carbonyl]-4-carbamoyl-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
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(4S,5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-(ethoxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-(hydroxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-(methoxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-carbamoyl-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-methoxy-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(4-tert-butylphenyl)carbonyl]-2-(2-methylpropyl)-4-(phenylcarbamoyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(4-tert-butylphenyl)carbonyl]-2-(2-methylpropyl)-4-[[(2-phenylethoxy)sulfinyl]carbamoyl]-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(4-tert-butylphenyl)carbonyl]-4-(methylcarbamoyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(4-tert-butylphenyl)carbonyl]-4-carbamoyl-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-1-[(4-tert-butylphenyl)carbonyl]-4-carbamoyl-2-(2-methylpropyl)-5-thiophen-2-yl-L-proline
-
-
(4S,5R)-1-[(4-tert-butylphenyl)carbonyl]-4-[(methoxysulfinyl)carbamoyl]-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-2-(2-methylpropyl)-4-(phenylcarbamoyl)-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-2-(2-methylpropyl)-4-[(2-phenylethyl)carbamoyl]-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-2-(2-methylpropyl)-5-thiophen-2-yl-4-[[(trifluoromethoxy)sulfinyl]carbamoyl]-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-4-(benzylcarbamoyl)-1-[(4-tert-butylphenyl)carbonyl]-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(4S,5R)-4-(ethylcarbamoyl)-2-(2-methylpropyl)-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-4-(methylcarbamoyl)-2-(2-methylpropyl)-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-4-carbamoyl-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-4-carbamoyl-2-(2-methylpropyl)-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-4-[(1-methylethyl)carbamoyl]-2-(2-methylpropyl)-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-4-[(methoxysulfinyl)carbamoyl]-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-4-[(methoxysulfinyl)carbamoyl]-2-(2-methylpropyl)-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]-L-proline
-
-
(4S,5R)-4-[[(benzyloxy)sulfinyl]carbamoyl]-1-[(4-tert-butylphenyl)carbonyl]-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(5,7-difluoro-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
-
-
(5,8-dicyano-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
-
-
(5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H-[1]benzothieno[2,3-c]pyran-1-yl)acetic acid
-
-
(5-cyano-8-fluoro-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
-
-
(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
-
-
(5-cyano-8-methyl-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
-
-
(5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-(methoxymethyl)-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
-
-
(5S)-5-tert-butyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)-1,5-dihydro-2H-pyrrol-2-one
-
-
(6R,7R,8S,9R)-4-bromo-7,8-dihydroxy-7,8,9,10-tetrahydro-5H,6H-6,9-epoxy-1,2,5a,10a-tetraazacycloocta[1,2,3-cd]inden-5-one
-
-
(NH4)2SO4
-
above 60 mM
([[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]oxy]methyl)phosphonic acid
-
-
1,3-bis-(4-chloro-1H(3H)-triazolo[4,5-g]quinoline)propan-2-one
-
moderate antiproliferative activity for the cell lines tested
1,3-dimethyl-N-[4-(pyrrolidin-1-ylsulfonyl)phenyl]-1H-pyrazole-5-carboxamide
-
-
1-(1-methylethyl)-N-[4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
-
-
1-(2,5-difluorophenyl)-3-(2,5-difluorophenyl)triazene
1-(2,5-difluorophenyl)-3-(3'-trifluoromethylphenyl)triazene
1-(2,5-difluorophenyl)-3-phenyltriazene
1-(2,5-difluorophenyl)azopyrrolidine
1-(2-cyclopropylethyl)-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxyquinolin-2(1H)-one
-
-
1-(3,4-dichlorophenyl)azopyrrolidine
1-(3-bromophenyl)azopiperidine
1-(3-bromophenyl)azopyrrolidine
1-(3-chloro)-3-phenyltriazene N-methyl
1-(3-chlorophenyl)azopiperidine
1-(3-chlorophenyl)azopyrrolidine
1-(3-nitrophenyl)-3-(3'-nitrophenyl)triazene
1-(3-nitrophenyl)-3-methyl-3-phenyltriazene
1-(3-nitrophenyl)-3-phenyltriazene
1-(3-nitrophenyl)azopiperidine
1-(3-nitrophenyl)azopyrrolidine
1-(3-trifluoromethylphenyl)azopyrrolidine
1-(4-bromophenyl)azopiperidine
1-(4-bromophenyl)azopyrrolidine
1-(4-chlorophenyl)azopiperidine
1-(4-chlorophenyl)azopyrrolidine
1-(4-methoxyphenyl)azopyrrolidine
1-(4-methylphenyl)-3-methyl-3-phenyltriazene
1-(4-nitrophenyl)azopyrrolidine
1-(cyclobutylamino)-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one
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1-benzyl-N-[4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
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1-cyclohexyl-2-(2-fluoro-4-[[2-(3-oxomorpholin-4-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(2-fluoro-4-[[2-(4-hydroxypiperidin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(2-fluoro-4-[[2-(4-methylpiperazin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(2-fluoro-4-[[2-methoxy-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(2-fluoro-4-[[2-morpholin-4-yl-5-(2-oxopiperidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(2-fluoro-4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(2-fluoro-4-[[5-(2-oxopyrrolidin-1-yl)-2-piperidin-1-ylbenzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(3-furyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-indole-5-carboxylic acid
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1-cyclohexyl-2-(4-[[4-(dimethylcarbamoyl)phenyl](phenyl)methoxy]-2-fluorophenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(4-[[5-(1,1-dioxidoisothiazolidin-2-yl)-2-morpholin-4-ylbenzyl]oxy]-2-fluorophenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-(4-[[5-(dimethylcarbamoyl)-2-morpholin-4-ylbenzyl]oxy]-2-fluorophenyl)-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-furan-3-yl-N-[(1S)-2-(5-hydroxy-1H-indol-3-yl)-1-(1,3-thiazol-4-yl)ethyl]-1H-benzimidazole-5-carboxamide
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1-cyclohexyl-2-phenyl-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-phenyl-1H-indole-5-carboxylic acid
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1-cyclohexyl-2-[2-fluoro-4-([5-[(1-methylethyl)carbamoyl]-2-morpholin-4-ylbenzyl]oxy)phenyl]-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-[2-fluoro-4-([5-[(methoxyacetyl)(methyl)amino]-2-morpholin-4-ylbenzyl]oxy)phenyl]-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-2-[2-fluoro-4-[(2-morpholin-4-ylbenzyl)oxy]phenyl]-1H-benzimidazole-5-carboxylic acid
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1-cyclohexyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-pyridin-2-yl-1H-benzimidazole-5-carboxamide
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1-ethyl-N-[4-[(2-methylpiperidin-1-yl)sulfonyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
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1-methyl-3-(trifluoromethyl)-N-[4-(pyrrolidinylsulfonyl)-phenyl]-1H-pyrazole-5-carboxamide
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specific inhibitor, inhibits RdRp complex activity