Literature summary for 2.7.7.48 extracted from

Gent, J.I.; Schvarzstein, M.; Villeneuve, A.M.; Gu, S.G.; Jantsch, V.; Fire, A.Z.; Baudrimont, A.
A Caenorhabditis elegans RNA-directed RNA polymerase in sperm development and endogenous RNA interference (2009), Genetics, 183, 1297-1314.

Search for more literature for 2.7.7.48

Protein Variants

Protein Variants	Comment	Organism
additional information	identification of RRF-3 siRNAs, overview. RRF-3 suppression by siRNA results in pleiotropic effects in sperm development, the sperm defects lead to embryonic lethality, nuclei of the mutant sperms are surrounded by ectopic microtubule structures with spindle abnormalities, phenotype, overview	Caenorhabditis elegans

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	-	gene rrf-3	-
Caenorhabditis elegans Bristol N2	-	gene rrf-3	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
sperm	-	Caenorhabditis elegans	-

Synonyms

Synonyms	Comment	Organism
RDRP	-	Caenorhabditis elegans
RRF-3	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
malfunction	RRF-3 mutation is involved in compromised spermatogenesis, that accounts for reduced brood size and X-chromosome loss from rrf-3 mutant hermaphrodites	Caenorhabditis elegans
physiological function	RRF-3 is required for spermatocyte cell division, overview	Caenorhabditis elegans

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Release 2023.1 (January 2023)