Literature summary for 2.7.7.48 extracted from

Thal, M.A.; Wasik, B.R.; Posto, J.; Hardy, R.W.
Template requirements for recognition and copying by Sindbis virus RNA-dependent RNA polymerase (2007), Virology, 358, 221-232.

Search for more literature for 2.7.7.48

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nucleoside triphosphate + RNAn	Sindbis virus	nsP4 possesses the RNA-dependent RNA polymerase activity required for the replication of the SIN genome and transcription of a subgenomic mRNA during infection	diphosphate + RNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Sindbis virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	nsP4 possesses the RNA-dependent RNA polymerase activity required for the replication of the SIN genome and transcription of a subgenomic mRNA during infection	Sindbis virus	diphosphate + RNAn+1	-	?
nucleoside triphosphate + RNAn	in the absence of other viral proteins nsP4 is capable of copying SIN plus- and minus-strand templates, but does not transcribe subgenomic RNA. Mutations in the 3' conserved sequence element and poly(A) tail of the plus-strand template prevent nsP4-mediated de novo initiation of minus-strand RNA synthesis. nsP4-dependent terminal addition of nucleotides occurs on template RNA possessing certain mutations in the 3' conserved sequence element and polyadenylate tail. nsP4 is capable of minus-strand synthesis independent of the sequence at the 5' end of the template. An A-U rich sequence in the 3' conserved sequence element represents a binding site for a replicase component. Probably nsP4 plus-strand genomic RNA synthesis is dependent on the 3' end of the minus-strand template	Sindbis virus	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
nsp4	-	Sindbis virus

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Release 2023.1 (January 2023)