Literature summary for 2.7.7.48 extracted from

Kong, L.; Li, S.; Han, X.; Xiang, Z.; Fang, X.; Li, B.; Wang, W.; Zhong, H.; Gao, J.; Ye, L.
Inhibition of HCV RNA-dependent RNA polymerase activity by aqueous extract from Fructus Ligustri Lucidi (2007), Virus Res., 128, 9-17.

Search for more literature for 2.7.7.48

Application

Application	Comment	Organism
medicine	NS5B is strictly required for viral replication and thus represents an attractive therapeutic target	Hepacivirus C

Inhibitors

Inhibitors	Comment	Organism	Structure
Fructus Ligustri Lucidi aqueous extract	0.005 mg/ml, inhibits intracellular NS5B-catalyzed RNA synthesis	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	HepG2, Hep3B, and Bel-7402 cells transfected with	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Hepacivirus C	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
NS5B	-	Hepacivirus C
RDRP	-	Hepacivirus C
RNA-dependent RNA polymerase	-	Hepacivirus C

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Release 2023.1 (January 2023)