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Literature summary for 2.7.7.48 extracted from

  • Garcia-Ruiz, H.; Takeda, A.; Chapman, E.J.; Sullivan, C.M.; Fahlgren, N.; Brempelis, K.J.; Carrington, J.C.
    Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection (2010), Plant Cell, 22, 481-496.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9LQV2 isoform RDR1
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Arabidopsis thaliana Q9SG02 isoform RDR6
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Synonyms

Synonyms Comment Organism
RDR1
-
 Arabidopsis thaliana
RDR6
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 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function systematic analysis of susceptibility and small RNA formation in Arabidopsis mutants lacking combinations of RNA-dependent RNA polymerase isoforms and dicer-like proteins. The vast majority of turnip mosaic virus-derived small interfering RNAs are dependent on dicer-like protein isoform DCL4 and RNA polymerase isoform RDR1, although full antiviral defense also requires isoforms DCL2 and RDR6. DCL4 is sufficient for antiviral silencing in inoculated leaves, but isoforms DCL2 and DCL4 are both involved in silencing in systemic tissues. Basal levels of antiviral RNA silencing and siRNA biogenesis are detected in mutants lacking isoforms RDR1, RDR2, and RDR6, indicating an alternate route to form double-stranded RNA that does not depend on the three previously characterized RNA-dependent RNA polymerase proteins Arabidopsis thaliana