Literature summary for 2.7.7.48 extracted from

Lee, G.; Piper, D.E.; Wang, Z.; Anzola, J.; Powers, J.; Walker, N.; Li, Y.
Novel inhibitors of hepatitis C virus RNA-dependent RNA polymerases (2006), J. Mol. Biol., 357, 1051-1057.

Search for more literature for 2.7.7.48

Inhibitors

Inhibitors	Comment	Organism	Structure
5-(4-bromophenylmethylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine	reversible and non-competitive with nucleotides. Inhibitor appear to form a reversible covalent bond with the NS5B cysteine 366	Hepacivirus C
5-(4-chlorophenylmethylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine	reversible and non-competitive with nucleotides. Inhibitor appear to form a reversible covalent bond with the NS5B cysteine 366	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Hepacivirus C

Synonyms

Synonyms	Comment	Organism
HCN NS5B protein	-	Hepacivirus C

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00044	-	37°C, pH 7.5	Hepacivirus C	5-(4-bromophenylmethylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine
0.00054	-	37°C, pH 7.5	Hepacivirus C	5-(4-chlorophenylmethylene)-3-(benzenesulfonylamino)-4-oxo-2-thionothiazolidine

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Release 2023.1 (January 2023)