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Literature summary for 2.7.7.48 extracted from

  • Strauss, D.M.; Wuttke, D.S.
    Characterization of protein-protein interactions critical for poliovirus replication: analysis of 3AB and VPg binding to the RNA-dependent RNA polymerase (2007), J. Virol., 81, 6369-6378.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Enterovirus C

Localization

Localization Comment Organism GeneOntology No. Textmining
vesicle 3AB is a membrane-binding protein responsible for the localization of the polymerase to the membranous vesicles at which replication occurs Enterovirus C 31982
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Organism

Organism UniProt Comment Textmining
Enterovirus C
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strains 3D and 3AB
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn VPg (a peptide comprising the 3B region of protein 3AB) is the 22-residue soluble product of 3AB cleavage and serves as the protein primer for RNA replication Enterovirus C diphosphate + RNAn+1
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Synonyms

Synonyms Comment Organism
RNA-dependent RNA polymerase
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Enterovirus C