Information on EC 2.4.1.1 - glycogen phosphorylase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
2.4.1.1
-
RECOMMENDED NAME
GeneOntology No.
glycogen phosphorylase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
sequential mechanism
-
[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
proposal for catalytic mechanism
-
[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
catalytic mechanism of alpha-retaining glucosyl transfer, His334 is involved in selectively stabilizing the oxycarbenium ion-like transition state of the reaction, ligand binding
-
[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
catalytic site structure
-
[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
sequential random bi bi mechanism
O66932
[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
determination and analysis of rgulatory binding sites
-
[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
sequential bi-bi catalytic mechanism; sequential bi-bi mechanism
Q8U0Q0
[(1->4)-alpha-D-glucosyl]n + phosphate = [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hexosyl group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
glycogen degradation I
-
glycogen degradation II
-
Metabolic pathways
-
Starch and sucrose metabolism
-
starch biosynthesis
-
starch degradation III
-
starch degradation V
-
sucrose biosynthesis II
-
SYSTEMATIC NAME
IUBMB Comments
(1->4)-alpha-D-glucan:phosphate alpha-D-glucosyltransferase
This entry covers several enzymes from different sources that act in vivo on different forms of (1->4)-alpha-D-glucans. The accepted name should be modified for each specific instance by substituting "glycogen" with the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, etc.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
1,4-alpha-glucan phosphorylase
-
-
-
-
alpha-1,4-glycan phosphorylase
Q9LKJ3
-
alpha-glucan phosphorylase
-
-
-
-
alpha-glucan phosphorylase
-
-
alpha-glucan phosphorylase
-
-
-
alpha-glucan phosphorylase
-
-
alpha-glucan phosphorylase
Q9ATK9
-
alpha-glucan phosphorylase H
Q9SD76
-
alpha-glucan/maltodextrin phosphorylase
Q8U0Q0
-
amylopectin phosphorylase
-
-
-
-
amylophosphorylase
-
-
-
-
cyosolic phosphorylase
-
-
GlgP
Thermus caldophilus GK24
-
-
-
glucan phosphorylase
-
-
-
-
glucan phosphorylase
-
-
glucosan phosphorylase
-
-
-
-
glycogen phosphorylase
-
-
-
-
glycogen phosphorylase
-
-
glycogen phosphorylase
O66932
-
glycogen phosphorylase
-
-
glycogen phosphorylase
-
-
glycogen phosphorylase
P00489
-
glycogen phosphorylase
-
-
glycogen phosphorylase
Q9LKJ3
-
glycogen phosphorylase a
-
-
glycogen phosphorylase a
-
-
glycogen phosphorylase-a
-
-
GPase a
-
active enzyme form
GPBB
-
-
GPH
Q596I0
-
granulose phosphorylase
-
-
-
-
maltodextrin phosphorylase
-
-
-
-
maltodextrin phosphorylase
-
-
muscle phosphorylase
-
-
-
-
muscle phosphorylase a and b
-
-
-
-
myophosphorylase
-
-
-
-
myophosphorylase
-
-
PF1535
Q8U0Q0
locus name
Pho 2
-
-
Pho1
-
-
Pho1
Q9ATK9
-
phosphorylase a
-
-
-
-
phosphorylase a
-
-
phosphorylase a
-
-
phosphorylase b
-
-
phosphorylase, alpha-glucan
-
-
-
-
plastidial phosphorylase
-
-
polyphosphorylase
-
-
-
-
potato phosphorylase
-
-
-
-
starch phosphorylase
-
-
-
-
starch phosphorylase
-
-
starch phosphorylase
-
-
starch phosphorylase
-
-
starch phosphorylase
Q9LKJ3
-
starch phosphorylase H
Q9SD76
-
type L alpha-glucan phosphorylase
Q9ATK9
-
maltodextrin phosphorylase
-
-
additional information
-
enzyme belongs to the GT-B-fold glycosyltransferase superfamily
CAS REGISTRY NUMBER
COMMENTARY
9035-74-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
brown bullhead catfish
-
-
Manually annotated by BRENDA team
gene glgP
SwissProt
Manually annotated by BRENDA team
variety KB 560
-
-
Manually annotated by BRENDA team
isoform PhoA
SwissProt
Manually annotated by BRENDA team
isoform PhoB, encoded by STA4
SwissProt
Manually annotated by BRENDA team
ORF Cthe0357
-
-
Manually annotated by BRENDA team
regulation of gene expression according to seasonal variation in glycogen content
SwissProt
Manually annotated by BRENDA team
syn. Rhodotorula peneaus, strain 48-23A
-
-
Manually annotated by BRENDA team
var. flavescens
-
-
Manually annotated by BRENDA team
slime mould, strain Ax3
-
-
Manually annotated by BRENDA team
slime mould, strain NC-4
-
-
Manually annotated by BRENDA team
yellow yam
-
-
Manually annotated by BRENDA team
white yam
-
-
Manually annotated by BRENDA team
Gracilaria sordida
-
-
-
Manually annotated by BRENDA team
Gracilaria sordida
strain Harv. W.Nelson
-
-
Manually annotated by BRENDA team
Gracilaria sordida Harv.
strain Harv. W.Nelson
-
-
Manually annotated by BRENDA team
American lobster
-
-
Manually annotated by BRENDA team
isoform BB
-
-
Manually annotated by BRENDA team
phosphorylase a
UniProt
Manually annotated by BRENDA team
phosphorylase a
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
recombinant phosphorylase a
-
-
Manually annotated by BRENDA team
Indocibium guttattam
deap-sea fish
-
-
Manually annotated by BRENDA team
sweet potato, Lam. cv. Tainon 65
-
-
Manually annotated by BRENDA team
hawk moth
-
-
Manually annotated by BRENDA team
diabetic ob/ob mice
-
-
Manually annotated by BRENDA team
banana. Phosphorylase activity is induced during ripening and is associated with the onset of starch degradation. Regulation is mainly dependent on gene expression, and the absence of ethylene perception by 1-methylcyclopropane has a positive effect
-
-
Manually annotated by BRENDA team
banana, cooking variety
-
-
Manually annotated by BRENDA team
wild-type strain CM
-
-
Manually annotated by BRENDA team
isoform tGPGG, expression levels respond to environmental salinity changes. Glycogen content, phosphorylase protein amount and activity are significantly higher in fish acclimated to seawater than those in freshwater
-
-
Manually annotated by BRENDA team
commercial preparation
-
-
Manually annotated by BRENDA team
glycogen phosphorylase a
-
-
Manually annotated by BRENDA team
glycogen phosphorylase a
SwissProt
Manually annotated by BRENDA team
glycogen phosphorylase b
SwissProt
Manually annotated by BRENDA team
glycogen phosphorylase b
-
-
Manually annotated by BRENDA team
isoform phosphorylase b
-
-
Manually annotated by BRENDA team
phosphorylase a
-
-
Manually annotated by BRENDA team
phosphorylase a
SwissProt
Manually annotated by BRENDA team
phosphorylase b
SwissProt
Manually annotated by BRENDA team
-
Q9ATK9
UniProt
Manually annotated by BRENDA team
cv. Tainong 67, enzyme Pho1
-
-
Manually annotated by BRENDA team
submergence tolerant and submergence susceptible strains
-
-
Manually annotated by BRENDA team
strain Shear Dugg
-
-
Manually annotated by BRENDA team
Phymatotrichopsis omnivora Shear Dugg
strain Shear Dugg
-
-
Manually annotated by BRENDA team
Physarum polycephalum M3c
M3c
-
-
Manually annotated by BRENDA team
pea, cv. Kelvedon Wonder
-
-
Manually annotated by BRENDA team
var. kleine Rheinlnderin
-
-
Manually annotated by BRENDA team
Victory Freezer
-
-
Manually annotated by BRENDA team
adult male and female Wistar rats
-
-
Manually annotated by BRENDA team
adult, male
-
-
Manually annotated by BRENDA team
male Wistar
-
-
Manually annotated by BRENDA team
male Wistar rats
-
-
Manually annotated by BRENDA team
male, Wistar
-
-
Manually annotated by BRENDA team
bottom fermenting brewer's yeast
-
-
Manually annotated by BRENDA team
cyclin-dependent protein kinase Pho85p controls the phosphorylation state of phosphorylase and thereby its activity
-
-
Manually annotated by BRENDA team
strain PH5-3, harbouring plasmid Yep24::GPH1
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae PH5-3
strain PH5-3, harbouring plasmid Yep24::GPH1
-
-
Manually annotated by BRENDA team
cuttle fish
-
-
Manually annotated by BRENDA team
cv. Adelheid or Rosa
-
-
Manually annotated by BRENDA team
type L alpha-glucan phosphorylase
-
-
Manually annotated by BRENDA team
spinach, var. Frremona or Kasperik
-
-
Manually annotated by BRENDA team
strain GK24, overexpression of enzyme in Escherichia coli
-
-
Manually annotated by BRENDA team
Thermus caldophilus GK24
strain GK24, overexpression of enzyme in Escherichia coli
-
-
Manually annotated by BRENDA team
cytosolic isozyme; var. Star, 3 tissue-dependent enzyme isoforms P1, P2, and P3
SwissProt
Manually annotated by BRENDA team
isoform Pho1
UniProt
Manually annotated by BRENDA team
Voandzeia subterranea
Bamberra groundnut, var. Thouars.
-
-
Manually annotated by BRENDA team
Inrafrh
-
-
Manually annotated by BRENDA team
sweet corn, var. Golden Bantam, Iowa Belle 104
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
physiological function
-
molecular crowding by 1 M trimethylamine N-oxide stimulates phosphorylase b and phosphorylase kinase combined binding on glycogen particles. Phosphorylase kinase binding to glycogen particles containing adsorbed phosphorylase shows a two-stage character. At the initial stage, limited size particles with hydrodynamic radius of about 220 nm are formed, whereas the second stage is accompanied by linear growth of hydrodynamic radius. Flavin adenine dinucleotide selectively inhibits phosphorylase kinase binding at the second stage, while its binding in the second stage does not involve phosphorylase b
physiological function
-, C0LEJ1
a gene disruption mutant shows a twofold reduction of glycogen phosphorylase activity and an increased glycogen accumulation. The mutant has higher survival rates than the wild type after exposure to starvation, desiccation and osmotic pressure. The mutant is compromised in its biofilm formation ability and shows a decrease in the amount of glucose, accompanied by increases in rhamnose, fucose and ribose in its exopolysaccharides
physiological function
B2LXU4
isoform Pho1 may play an important role in recycling glucosyl units from malto-oligosaccharides back into starch synthesis in the developing wheat endosperm. Protein and enzyme activity increase throughout the period of starch synthesis
physiological function
Q9ATK9
the endosperm-specific plastidial alpha-glucan phosphorylase is important for synthesis of short-chain malto-oligosaccharides, it has an essential role during the initiation process of starch biosynthesis during rice seed development
physiological function
-
glycogen phosphorylase catalyses the breakdown of glycogen to glucose 1-phosphate. In the liver this is metabolized further to glucose which is then secreted into the bloodstream
physiological function
-
glycogen phosphorylase is a rate-limiting enzyme of glycogen degradation
evolution
Q9ATK9
plants contain two major Pho forms: the plastidial Pho1 or PhoL (low glycogen affinity) encoded by the PHO1 gene and a cytosolic Pho2 or PhoH (high glycogen affinity) encoded by the PHO2 gene
additional information
-
phosphorylase a is produced and isolated utilizing purified phosphorylase b and commercially available phosphorylase kinase
additional information
-
structural analysis of molecular elements that govern molecular recognition by the catalytic site of the enzyme with emphasis in the beta-pocket environment, overview
additional information
-
the glycogen phosphorylase dimer can exist in either in unphosphorylated glycogen phosphorylase b or phosphorylated glycogen phosphorylase a form depending on hormonal activation of kinase/phosphatase reactions
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is glycogen
-
-
?
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is glycogen
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is glycogen
-
-
?
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is glycogen, first step in glycogen breakdown removing one glucose at a time
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
O66932
polysaccharide substrate is glycogen, mobilization of glucose 1-phosphate as readily useable energy source
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is starch, phosphorolysis is the physiologic reaction of the starch degrading enzyme
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Q9LKJ3
the cytosolic isozyme is involved in the processing of incoming carbohydrate during rapid tissue growth, plastidic isozyme is associated with transitory leaf starch metabolism and with the initiation of seed endosperm reserve starch accumulation, but it plays no role in the degradation of the reserve starch
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is bovine liver glycogen
-
-
?
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is glycogen, phosphorolysis is the preferred reaction
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
O66932
polysaccharide substrates are glycogen and starch, phosphorolysis is the preferred reaction
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrates are soluble starch and Zulkowsky soluble starch, amylopectin, glycogen, and dextrin, amyylopectin is the best substrate
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrates are starch and glycogen, phosphorolysis is the preferred reaction, maltotetraose is the smallest substrate accepted
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Q9LKJ3
the cytosolic isozyme utilizes amylopectin, amylose, soluble starch, and glycogen as polysaccharide substrates, while the plastidic isozyme prefers starch
-
-
r
(1,4-alpha-D-glucosyl)n-1 + alpha-D-xylose 1-phosphate
alpha-D-xylose-(1,4-alpha-D-glucosyl)n + phosphate
show the reaction diagram
-
polysaccharide substrate is starch, very low activity
-
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
-
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
-
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
-
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
-
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
-
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
-
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
-
-
-
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
-
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
best substrate
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
preferred substrate
-
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
preferred substrate
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
not phosphorylase B
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
less effective than starch, amylose or glycogen
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
corn dextrin
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
achrodextrin
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
-
maltodextrin phosphorylase, preferred substrate
-
r
(dextrin)n-1 + glucose 1-phosphate
(dextrin)n + phosphate
show the reaction diagram
Phymatotrichopsis omnivora, Phymatotrichopsis omnivora Shear Dugg
-
corn dextrin, phosphorolysis at 85% the rate of glycogen phosphorolysis
-
r
(maltodextrin)n + phosphate
(maltodextrin)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
?
(maltodextrin)n-1 + alpha-D-glucose 1-phosphate
(maltodextrin)n + phosphate
show the reaction diagram
-
maltodextrin phosphorylase is involved in the utilization of maltodextrins
-
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
show the reaction diagram
-
-
-
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
show the reaction diagram
-
-
-
-
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
show the reaction diagram
-
minimum chain length requirement for efficient activity: 5 glucose units per maltodextrin molecule
-
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
show the reaction diagram
-
glucosylation at 96% the rate of maltoheptaose glucosylation
-
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
show the reaction diagram
-
maltodextrin with up to 11 glucose units
-
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
show the reaction diagram
-
minimum chain length requirement for efficient activity: 4 glucose units per maltodextrin molecule
-
r
(maltodextrin)n-1 + glucose 1-phosphate
(maltodextrin)n + phosphate
show the reaction diagram
-
phosphorolysis activity ceases when maltodextrins are degraded to maltotetraose
-
r
(maltooligosaccaride)n-1 + alpha-D-glucose 1-phosphate
(maltooligosaccharide)n + phosphate
show the reaction diagram
-, Q2VA40, Q2VA41
-
-
-
r
(maltooligosaccaride)n-1 + alpha-D-glucose 1-phosphate
(maltooligosaccharide)n + phosphate
show the reaction diagram
-, Q2VA40, Q2VA41
preferred substrate
-
-
r
alpha-D-glucose-1-phosphate + maltohexaose
amylose + phosphate
show the reaction diagram
-
-
in presence of lipids, spontaneous formation and precipitation of amylose-lipid complexes. Presence of lipid also leads to lower amylose degrees of polymerization. Lipid chain length defines degree of amylose polymerization, which increases in the order myristic acid, glyceryl monostearate, stearic acid and docosanoic acid. Thermal stability of complexes increases in the same manner
-
?
amylopectin + alpha-D-glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
Q9SD76
-
-
-
?
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
-
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
-
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
-
-
-
-
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
-
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
-
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
-
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
-
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
best substrate
-
-
-
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
best substrate
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
preferred substrate
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
effective primer
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
less effective than starch, amylose or glycogen
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
potato amylopectin
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
potato amylopectin
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
glucosylation at 23% the rate of maltoheptaose glucosylation
-
r
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
waxy rice or pea cotyledon
-
-
-
amylopectin + glucose 1-phosphate
amylopectin + phosphate
show the reaction diagram
-
waxy maize amylopectin
-
r
amylopectin + phosphate
amylopectin + D-glucose-1-phosphate
show the reaction diagram
Thermus caldophilus, Thermus caldophilus GK24
-
-
-
-
?
amylose + glucose 1-phosphate
amylose + phosphate
show the reaction diagram
-
-
-
?
amylose + glucose 1-phosphate
amylose + phosphate
show the reaction diagram
-
-
-
r
amylose + glucose 1-phosphate
amylose + phosphate
show the reaction diagram
-
-
-
?
amylose + glucose 1-phosphate
amylose + phosphate
show the reaction diagram
-
best substrate
-
?
amylose + glucose 1-phosphate
amylose + phosphate
show the reaction diagram
-
effective primer
-
r
amylose + glucose 1-phosphate
amylose + phosphate
show the reaction diagram
-
glucosylation at 7% the rate of maltoheptaose glucosylation
-
?
amylose + glucose 1-phosphate
amylose + phosphate
show the reaction diagram
-
potato amylose
-
r
amylose + phosphate
amylose + glucose 1-phosphate
show the reaction diagram
-
-
-
?
amylose + phosphate
amylose + glucose 1-phosphate
show the reaction diagram
-
arsenate can replace phosphate
-
?
amylose + phosphate
amylose + glucose 1-phosphate
show the reaction diagram
-
pea cotyledon amylose
-
?
amylose + phosphate
amylose + D-glucose-1-phosphate
show the reaction diagram
Thermus caldophilus, Thermus caldophilus GK24
-
-
-
-
?
debranched amylopectin + glucose 1-phosphate
debranched amylopectin + phosphate
show the reaction diagram
-
most effective primer glucan for chloroplastic enzyme
-
r
dextrin + alpha-D-glucose 1-phosphate
dextrin + phosphate
show the reaction diagram
-
-
-
-
-
dextrin + alpha-D-glucose 1-phosphate
dextrin + phosphate
show the reaction diagram
Q9SD76
-
-
-
?
dextrin DP13 + alpha-D-glucose 1-phosphate
detrin DP14 + phosphate
show the reaction diagram
-
prolongation of the dextrin molecule with one glucose monomer
-
-
r
dextrin DP14 + phosphate
detrin DP13 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
dextrin DP18 + alpha-D-glucose 1-phosphate
detrin DP19 + phosphate
show the reaction diagram
-
prolongation of the dextrin molecule with one glucose monomer
-
-
r
dextrin DP19 + phosphate
detrin DP18 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
dextrin DP3 + alpha-D-glucose 1-phosphate
detrin DP4 + phosphate
show the reaction diagram
-
prolongation of the dextrin molecule with one glucose monomer
-
-
r
dextrin DP4 + phosphate
detrin DP3 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
-
?
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-, Q2VA40, Q2VA41
-
-
-
r
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
Q9SD76
-
-
-
?
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
enzyme catalyzes the initial degradation of glycogen
-
-
?
glycogen + alpha-D-glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
Q8U0Q0
75% of the activity with maltose, 64% of the activity with maltoheptaose
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
-
?
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
-
?
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
Indocibium guttattam
-
-
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
poor substrate
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
best substrate
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
best substrate
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
favoured reaction
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
rabbit liver glycogen
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
rabbit liver glycogen
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
rabbit liver glycogen
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
preferred substrate of glycogen phosphorylase
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
not phosphorylase B
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
about half as effective as dextrin
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
phytoglycogen
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from oyster
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from oyster
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from oyster
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from oyster
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from oyster
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from oyster
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from oyster
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
yeast or rabbit enzyme
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from: oyster
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from: oyster
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
endogenous glycogen
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from: rabbit liver
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from: rabbit liver
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from: rabbit liver
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from: rabbit liver
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from Streptococcus salivarius
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glucosylation at 14.4% the rate of maltoheptaose glucosylation
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
-
glycogen from shell fish
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
Saccharomyces cerevisiae PH5-3
-
favoured reaction
-
r
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
Phymatotrichopsis omnivora Shear Dugg
-
best substrate
-
-
-
glycogen + glucose 1-phosphate
glycogen + phosphate
show the reaction diagram
Physarum polycephalum M3c
-
glycogen from oyster, glycogen from Streptococcus salivarius
-
r
glycogen + phosphate
glycogen + glucose 1-phosphate
show the reaction diagram
-
-
-
-
?
glycogen + phosphate
glycogen + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
glycogen + phosphate
glycogen + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
?
glycogen + phosphate
? + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
-
-
-
r
granulose + glucose 1-phosphate
granulose + phosphate
show the reaction diagram
-
-
-
?
maltodecaheptaose + glucose 1-phosphate
maltodecaoctaose + phosphate
show the reaction diagram
-
-
-
r
maltodecaose + alpha-D-glucose 1-phosphate
? + phosphate
show the reaction diagram
-
low activity
-
-
r
maltodextrin + phosphate
? + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
maltoheptaose + alpha-D-glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
O66932
-
-
-
r
maltoheptaose + alpha-D-glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
-
low activity
-
-
r
maltoheptaose + alpha-D-glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
Q9LKJ3
the cytosolic isozyme
-
-
r
maltoheptaose + alpha-D-glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
Q8U0Q0
80% of the activity with maltose
-
-
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
-
-
-
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
-
-
-
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
-
-
-
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
-
-
-
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
-
poor substrate
-
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
-
best substrate
-
r
maltoheptaose + glucose 1-phosphate
maltooctaose + phosphate
show the reaction diagram
-
isozyme I
-
r
maltoheptaose + phosphate
maltohexaose + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
-
-
-
r
maltoheptaose + phosphate
maltohexaose + alpha-D-glucose 1-phosphate
show the reaction diagram
Q9LKJ3
the cytosolic isozyme
-
-
r
maltoheptaose + phosphate
maltohexaose + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
35% of the activity with maltoheptaose
-
-
r
maltohexaose + alpha-D-glucose 1-phosphate
maltoheptaose + phosphate
show the reaction diagram
-
-
-
-
r
maltohexaose + alpha-D-glucose 1-phosphate
maltoheptaose + phosphate
show the reaction diagram
O66932
-
-
-
r
maltohexaose + alpha-D-glucose 1-phosphate
maltoheptaose + phosphate
show the reaction diagram
-
low activity
-
-
r
maltohexaose + alpha-D-glucose 1-phosphate
maltoheptaose + phosphate
show the reaction diagram
Q8U0Q0
82% of the activity with maltose
-
-
r
maltohexaose + arsenate
maltopentaose + glucose 1-arsenate
show the reaction diagram
-
-
-
?
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
show the reaction diagram
-
-
-
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
show the reaction diagram
-
-
-
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
show the reaction diagram
-
-
-
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
show the reaction diagram
-
-
-
r
maltohexaose + glucose 1-phosphate
maltoheptaose + phosphate
show the reaction diagram
-
-
-
r
maltohexaose + phosphate
maltopentaose + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
-, 85% of the activity with maltoheptaose
-
-
r
maltononaose + alpha-D-glucose 1-phosphate
maltodecaose + phosphate
show the reaction diagram
-
low activity
-
-
r
maltooctaose + alpha-D-glucose 1-phosphate
maltononaose + phosphate
show the reaction diagram
-
low activity
-
-
r
maltooctaose + glucose 1-phosphate
maltononaose + phosphate
show the reaction diagram
-
-
-
r
maltooctaose + glucose 1-phosphate
maltononaose + phosphate
show the reaction diagram
-
-
-
r
maltopentaose + alpha-D-glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
-
-
-
r
maltopentaose + alpha-D-glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
O66932
-
-
-
r
maltopentaose + alpha-D-glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
Q8U0Q0
86% of the activity with maltose
-
-
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
-
-
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
-
-
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
-
-
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
-
-
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
-
-
-
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
-
-
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
-
-
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
cytoplasmic enzyme, glucosylation at the same rate of glucosylation of debranched amylopectin, chloroplastic enzyme, glucosylation at 50% the rate of glucosylation of debranched amylopectin
-
r
maltopentaose + glucose 1-phosphate
maltohexaose + phosphate
show the reaction diagram
-
isozyme I
-
r
maltopentaose + phosphate
maltotetraose + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
?
maltopentaose + phosphate
maltotetraose + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
maltopentaose + phosphate
maltotetraose + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
-, 78% of the activity with maltoheptaose
-
-
r
maltopentaose + phosphate
?
show the reaction diagram
Q8KQ56
-
-
-
?
maltose + alpha-D-glucose 1-phosphate
maltotriose + phosphate
show the reaction diagram
Q8U0Q0
-
-
-
r
maltose + alpha-D-glucose 1-phosphate
maltotriose + phosphate
show the reaction diagram
-
-
-
?
maltose + alpha-D-glucose 1-phosphate
maltotriose + phosphate
show the reaction diagram
-
not phosphorylase B
-
?
maltose + alpha-D-glucose 1-phosphate
maltotriose + phosphate
show the reaction diagram
-
less effective than starch, amylose or glycogen
-
?
maltose + alpha-D-glucose 1-phosphate
?
show the reaction diagram
-
-
-
-
?
maltotetraose + 2-amino-2-deoxy-alpha-D-glucopyranosyl 1-phosphate
GlcNAc-alhpha-(1->4)-Glc-alhpha-(1->4)-Glc-alhpha-(1->4)-Glc-alhpha-(1->4)-Glc-alhpha-(1->4) + phosphate
show the reaction diagram
-
-
alpha-glucosamine is positioned at the non-reducing end of the oligosaccharide
-
?
maltotetraose + alpha-D-glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
-
-
-
r
maltotetraose + alpha-D-glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
O66932
-
-
-
r
maltotetraose + alpha-D-glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
Q9LKJ3
the cytosolic isozyme
-
-
r
maltotetraose + alpha-D-glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
Q8U0Q0
90% of the activity with maltose
-
-
r
maltotetraose + D-glucose-1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
-
-
-
?
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
-
-
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
-
-
ir
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
-
-
ir
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
-
-
-
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
-
-
ir
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
-
-
-
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
best substrate
-
ir
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
glucosylation at 22% the rate of maltoheptaose glucosylation
-
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
cytoplasmic enzyme: poor substrate
-
r
maltotetraose + glucose 1-phosphate
maltopentaose + phosphate
show the reaction diagram
-
smallest acceptor for synthesis
-
r
maltotetraose + phosphate
maltotriose + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
-
-
-
r
maltotetraose + phosphate
maltotriose + alpha-D-glucose 1-phosphate
show the reaction diagram
-
50% of the activity with maltopentaose
-
-
?
maltotetraose + phosphate
maltotriose + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
61% of the activity with maltoheptaose
-
-
r
maltotriose + alpha-D-glucose 1-phosphate
maltotetraose + phosphate
show the reaction diagram
-
-
-
-
r
maltotriose + alpha-D-glucose 1-phosphate
maltotetraose + phosphate
show the reaction diagram
O66932
maltotriose is the smallest substrate accepted for the synthetic reaction direction, maltotetraose is the smallest substrate accepted for the phosphorolytic reaction direction
-
-
r
maltotriose + alpha-D-glucose 1-phosphate
maltotetraose + phosphate
show the reaction diagram
Q8U0Q0
95% of the activity with maltose
-
-
r
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
show the reaction diagram
-
-
-
r
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
show the reaction diagram
-
-
-
ir
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
show the reaction diagram
-
-
-
r
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
show the reaction diagram
Q9FDQ9
-
-
r
maltotriose + glucose 1-phosphate
maltotetraose + phosphate
show the reaction diagram
-
less effective than starch, amylose or glycogen
-
r
soluble heteroglycan + alpha-D-glucose 1-phosphate
? + phosphate
show the reaction diagram
-
substrate is a soluble heteroppolysaccharide containing a high percentage of arabinogalactan-like linkages but also minor components, namely glucosyl, mannosyl, rhamnosyl, and fucosyl residues, and is isolated from pea leaf cytosol, 3 different variants, overview
-
-
?
starch + alpha-D-glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
-
?
starch + alpha-D-glucose 1-phosphate
starch + phosphate
show the reaction diagram
-, Q2VA40, Q2VA41
-
-
-
r
starch + alpha-D-glucose 1-phosphate
starch + phosphate
show the reaction diagram
-, Q2VA40, Q2VA41
preferred substrate
-
-
r
starch + alpha-D-glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
prolongation of the starch molecule with one glucose monomer
-
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
-
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
-
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
-
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
-
?
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
-
-
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
-
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
-
-
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
poor substrate
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
best substrate
-
-
-
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
best substrate
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
best substrate
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
-
-
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
potato enzyme
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
native chloroplast grains
-
-
-
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
glucosylation at 32% the rate of dextrin glucosylation
-
-
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
-
glucosylation of native starch granules occurs at 82%, isozyme P-1, or 11.5%, isozyme P-2, the rate of soluble starch, phosphorolysis at the same rate as soluble starch
-
r
starch + glucose 1-phosphate
starch + phosphate
show the reaction diagram
Phymatotrichopsis omnivora, Phymatotrichopsis omnivora Shear Dugg
-
phosphorolysis at 31% the rate of glycogen phosphorolysis
-
r
starch + phosphate
starch + D-glucose-1-phosphate
show the reaction diagram
Thermus caldophilus, Thermus caldophilus GK24
-
-
-
-
?
starch + phosphate
starch + D-glucose 1-phosphate
show the reaction diagram
P00489
-
-
-
?
starch + phosphate
? + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Gracilaria sordida
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Gracilaria sordida
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Voandzeia subterranea
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Q9FDQ9
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Indocibium guttattam
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Q9ATK9
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
no activity with sucrose
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
no activity with pullulan
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
no activity with pullulan
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
no activity with glucose 6-phosphate, fructose 6-phosphate, and fructose 1,6-diphosphate
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
no activity with glucose 6-phosphate, fructose 6-phosphate, and fructose 1,6-diphosphate
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
favoured reaction
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
no activity with ribose 5-phosphate, strict specificity for glucose 1-phosphate
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
strict specificity for glucose 1-phosphate
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
no activity with dextran
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
no activity with Schardinger dextrin and cellulose
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
no activity with Schardinger dextrin and cellulose
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
ineffective primer: glucose
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polyglucose primer required
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polyglucose primer required
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polyglucose primer required
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polyglucose primer required
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polyglucose primer required
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polyglucose primer required
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polyglucose primer required
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polyglucose primer required
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
catalyzes incorporation of glucose into alpha-1,4-glucosidic linkage on exterior chains of primer, glycogen synthesis is preferred
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
unprimed reaction: lag-phase, product presumably protein-bound glucan
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
glycogen metabolism
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
glycogen metabolism
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
glycogen metabolism
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
pathway in starch
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
pathway in starch
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
key step in cellular differentiation of Dictyostelium discoideum
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
maltose is the minimum primer for glucan synthesis and maltotriose is the minimum substrate for degradation
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
the liver enzyme catalyzes the forward reaction
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Q9ATK9
usage of four different assay methods
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
broad substrate specificity in both the synthesis and degradation of maltooligosaccharides In the synthetic direction of the enzymatic reaction, the lowest oligosaccharide required for the chain elongation is maltose. In the degradative direction the archaeal enzyme can produce D-glucose-1-phosphate from maltotriose or longer maltooligosaccharides including both glycogen and starch
-
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Saccharomyces cerevisiae PH5-3
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Phymatotrichopsis omnivora Shear Dugg
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Gracilaria sordida Harv.
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Physarum polycephalum M3c
-
-
-
r
maltotriose + phosphate
maltose + alpha-D-glucose 1-phosphate
show the reaction diagram
Q8U0Q0
-, 35% of the activity with maltoheptaose
-
-
r
additional information
?
-
-
increased enzyme activity increases 5-phosphoribosyl-1-diphosphate availability in hepatocyte cultures and vice versa, glycogenolysis is a major contributor to PRPP generation in liver tissue in the basal state
-
-
-
additional information
?
-
P00489
mastoparan binds to the enzyme to negatively regulate sarcoplasmic reticular Ca2+ release in skeletal muscle involving the ryanodine receptor, overview
-
-
-
additional information
?
-
-
the cell volume affects the activity in hepatocytes, thus the enzyme activity is a function of medium osmolarity, activity is increased in hyperosmotic media, overview
-
-
-
additional information
?
-
-
the enzyme regulates the association of glycogen synthase with a proteoglycogen substrate in hepatocytes
-
-
-
additional information
?
-
O66932
maltotriose is the smallest substrate accepted for the synthetic reaction direction, maltotetraose is the smallest substrate accepted for the phosphorolytic reaction direction
-
-
-
additional information
?
-
Q9LKJ3
substrate specificity of cytosolic isozyme
-
-
-
additional information
?
-
-
substrate specificity, no or nearly no activity with glucose, maltose, and maltotriose, overview
-
-
-
additional information
?
-
P00489
the enzyme specifically binds to mastoparan, a wasp venom toxin
-
-
-
additional information
?
-
-
enzyme is involved in starch degradation during submergence stress in rice plants
-
-
-
additional information
?
-
-, Q2VA40, Q2VA41
enzyme is involved in storage starch synthesis
-
-
-
additional information
?
-
-
phosphorylase GlgP catalyzes glycogen breakdown and affects glycogen structure by removing glucose units from the polysaccharide outer chains
-
-
-
additional information
?
-
-
glycogen phosphorylase is dynamically regulated during and after status in the adult rat, and may have an important role in the pilocarpine model of epilepsy
-
-
-
additional information
?
-
-
GPa reduces arsenate (As(V)) to the more toxic arsenite (As(III)) in a glutathione (GSH)-dependent fashion
-
-
-
additional information
?
-
-
a maltotetraosyl residue comprising the non-reducing-end of a pyridylaminated maltooligosaccharide is indispensable for the chain-lengthening action of phosphorylase
-
-
-
additional information
?
-
-
no substrate in direction of glucose 1-phosphate synthesis: pullulan, maltotriose
-
-
-
additional information
?
-
Q9ATK9
Pho1 not only degrades maltohexaose but also extends them to synthesize longer malto-oligosaccharides, production of a broad spectrum of MOSs (G4-G19) is stimulated both by phosphate and alpha-D-glucose 1-phosphate
-
-
-
additional information
?
-
-
broad substrate specificities for different chain length dextrins and soluble starch, enzyme efficiency on dextrin DP4 is approximately 5fold lower than that on dextrin DP14 although kcat on dextrin DP4 is higher than on dextrin DP14
-
-
-
additional information
?
-
-
the catalytic site binds glucose 1-phosphate, glycogen, glucose, and glucose analogues
-
-
-
additional information
?
-
-
broad substrate specificities for different chain length dextrins and soluble starch, enzyme efficiency on dextrin DP4 is approximately 5fold lower than that on dextrin DP14 although kcat on dextrin DP4 is higher than on dextrin DP14
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is glycogen
-
-
?
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is glycogen
-
-
?
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is glycogen, first step in glycogen breakdown removing one glucose at a time
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
O66932
polysaccharide substrate is glycogen, mobilization of glucose 1-phosphate as readily useable energy source
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
polysaccharide substrate is starch, phosphorolysis is the physiologic reaction of the starch degrading enzyme
-
-
r
(1,4-alpha-D-glucosyl)n + phosphate
(1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Q9LKJ3
the cytosolic isozyme is involved in the processing of incoming carbohydrate during rapid tissue growth, plastidic isozyme is associated with transitory leaf starch metabolism and with the initiation of seed endosperm reserve starch accumulation, but it plays no role in the degradation of the reserve starch
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
Q9ATK9
-
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
glycogen metabolism
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
glycogen metabolism
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
glycogen metabolism
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
pathway in starch
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
pathway in starch
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
key step in cellular differentiation of Dictyostelium discoideum
-
?
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
the liver enzyme catalyzes the forward reaction
-
-
r
[(1->4)-alpha-D-glucosyl]n + phosphate
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
show the reaction diagram
-
-
-
-
r
(maltodextrin)n-1 + alpha-D-glucose 1-phosphate
(maltodextrin)n + phosphate
show the reaction diagram
-
maltodextrin phosphorylase is involved in the utilization of maltodextrins
-
r
additional information
?
-
-
increased enzyme activity increases 5-phosphoribosyl-1-diphosphate availability in hepatocyte cultures and vice versa, glycogenolysis is a major contributor to PRPP generation in liver tissue in the basal state
-
-
-
additional information
?
-
P00489
mastoparan binds to the enzyme to negatively regulate sarcoplasmic reticular Ca2+ release in skeletal muscle involving the ryanodine receptor, overview
-
-
-
additional information
?
-
-
the cell volume affects the activity in hepatocytes, thus the enzyme activity is a function of medium osmolarity, activity is increased in hyperosmotic media, overview
-
-
-
additional information
?
-
-
the enzyme regulates the association of glycogen synthase with a proteoglycogen substrate in hepatocytes
-
-
-
additional information
?
-
-
enzyme is involved in starch degradation during submergence stress in rice plants
-
-
-
additional information
?
-
-, Q2VA40, Q2VA41
enzyme is involved in storage starch synthesis
-
-
-
additional information
?
-
-
phosphorylase GlgP catalyzes glycogen breakdown and affects glycogen structure by removing glucose units from the polysaccharide outer chains
-
-
-
additional information
?
-
-
glycogen phosphorylase is dynamically regulated during and after status in the adult rat, and may have an important role in the pilocarpine model of epilepsy
-
-
-
additional information
?
-
Q9ATK9
Pho1 not only degrades maltohexaose but also extends them to synthesize longer malto-oligosaccharides, production of a broad spectrum of MOSs (G4-G19) is stimulated both by phosphate and alpha-D-glucose 1-phosphate
-
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
2 mol per mol enzyme; requirement
pyridoxal 5'-phosphate
-
requirement
pyridoxal 5'-phosphate
-
requirement
pyridoxal 5'-phosphate
-
2 mol per mol enzyme
pyridoxal 5'-phosphate
-
1 mol/mol subunit; requirement
pyridoxal 5'-phosphate
-
requirement
pyridoxal 5'-phosphate
-
requirement
pyridoxal 5'-phosphate
-
1 mol/mol subunit; requirement
pyridoxal 5'-phosphate
-
1 mol/mol subunit; requirement
pyridoxal 5'-phosphate
-
additional pyridoxalphosphate inhibits; requirement
pyridoxal 5'-phosphate
-
requirement
pyridoxal 5'-phosphate
-
requirement
pyridoxal 5'-phosphate
-
2 mol per mol enzyme; requirement
pyridoxal 5'-phosphate
-
requirement
pyridoxal 5'-phosphate
-
1 pyridoxal 5'-phosphate/subunit
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
1.2 mol/subunit
pyridoxal 5'-phosphate
-
0.87 mol/subunit
pyridoxal 5'-phosphate
-
-
pyridoxal 5'-phosphate
-
dependent on, reversible dissociation study
pyridoxal 5'-phosphate
-
the 31P chemical shift of pyridoxal 5'-phosphate in the wild-type was pH-dependent and not perturbed by binding of arsenate. At pH 7.25, it is not sensitive to the replacement His334 by Gly
pyridoxal 5'-phosphate
-
about 0.7 mol per mol of protein
additional information
-
absence of pyridoxal 5'-phosphate
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ca2+
-
stimulates at 10 mM, inhibits at 1 mM
Ca2+
-
stimulates
Ca2+
-
activation
Ca2+
Q9ATK9
stimulates Pho1 activity by 1.5-1.8fold
Co2+
-
activation
Fe2+
-
stimulates at 1 mM, inhibits at 10 mM
Mg2+
-
activation
Mg2+
-
activation
Mg2+
Voandzeia subterranea
-
1 mM, 59% activation
Mg2+
-
activation; slight activation
Mg2+
-
activation
Mg2+
Q9ATK9
stimulates Pho1 activity by 1.5-1.8fold
Mg2+
-
activates at 1 mM
Mn2+
-
activation
Mn2+
Voandzeia subterranea
-
activation
Mn2+
-
activation; slight
NaF
-
activation, maximal at 200 mM
NaF
-
significant activation by synergism with AMP, glycogen as substrate; slight
Ni2+
-
activation
Mn2+
Q9ATK9
stimulates Pho1 activity by 1.5-1.8fold
additional information
-
not activated by Cl-
additional information
-
no divalent cations required
additional information
-
not activated by Na+
additional information
-
not activated by Cu2+
additional information
-
-
additional information
-
not activated by Cu2+; not activated by Zn2+
additional information
-
not affected by Na+, K+, Mg2+, Ca2+
additional information
-
no metal binding
additional information
Q9ATK9
Na+, K+, NH4-, and Li+ have essentially no effect on Pho1 activity, and no effect by 4 mM DTT
additional information
-
the enzyme is not affected by 1 mM of Ca2+, Cu2+, Zn2+, and Ni2+
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
(1S)-1,5-anhydro-D-glucitol-spiro[1.5]-3-(2-naphthyl)-1,4,2-oxathiazole
-
-
(1S)-1,5-anhydro-D-glucitol-spiro[1.5]-3-(4-methoxyphenyl)-1,4,2-oxathiazole
-
-
(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(2-chloro-6H-thieno[2,3-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-chloro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-chloro-1H-pyrrolo[2,3-c]pyridin-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-chloro-6-fluoro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-chloro-7-fluoro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2-[[(5-fluoro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
-
(2alpha)-3-hydroxyolean-12-en-28-oic acid
-
-
(2alpha,3beta)-2,3-bis(acetyloxy)olean-12-en-28-oic acid
-
-
(2alpha,3beta)-2,3-bis(butanoyloxy)olean-12-en-28-oic acid
-
-
(2alpha,3beta)-2,3-bis(propanoyloxy)olean-12-en-28-oic acid
-
-
(2beta)-2-hydroxyurs-12-en-28-oic acid
-
-
(2beta)-3-hydroxyolean-12-en-28-oic acid
-
-
(2beta,3alpha)-2,3-dihydroxyolean-12-en-28-oic acid
-
-
(2beta,3alpha)-2,3-dihydroxyurs-12-en-28-oic acid
-
-
(2E,2'E)-N,N'-(oxydiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide]
-
-
(2E,2'E)-N,N'-(thiodiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide]
-
-
(2E,2'E)-N,N'-butane-1,4-diylbis[3-(3,4-dichlorophenyl)-acrylamide]
-
-
(2E,2'E)-N,N'-pentane-1,5-diylbis[3-(3,4-dichlorophenyl)acrylamide]
-
crystallization data
(2R)-2-cyclohexyl-2-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]propanoic acid
-
potent in vitro inhibition, reduced inhibition of CYP2C9 and good pharmacokinetic properties
(2R,3R,4S,5R,6R)-3,4,5,9-tetrahydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione
-
-
(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione
-
-
(2S)-2-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]heptanoic acid
-
-
(2S)-cyclohexyl[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]ethanoic acid
-
-
(2S)-cyclopentyl[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]ethanoic acid
-
-
(2Z)-2-(hydroxyimino)olean-12-en-28-oic acid
-
-
(2Z)-2-(hydroxyimino)urs-12-en-28-oic acid
-
-
(3beta)-28-[(2-[[2-(acetylamino)ethyl]amino]ethyl)amino]-28-oxoolean-12-en-3-yl acetate
-
-
(3beta)-28-[(3-aminopropyl)amino]-28-oxolup-20(29)-ene-3,23-diyl diacetate
-
-
(3beta)-28-[(6-aminohexyl)amino]-28-oxolup-20(29)-ene-3,23-diyl diacetate
-
-
(3beta)-3-[[(4-[[(phenylacetyl)oxy]methyl]-1H-1,2,3-triazol-1-yl)acetyl]oxy]olean-12-en-28-oic acid
-
-
(3beta)-N-(6-aminohexyl)-3,23-dihydroxylup-20(29)-en-28-amide
-
-
(3beta,12alpha,13xi)-3,12-dihydroxyoleanan-28-oic acid
-
-
(3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oic acid
-
-
(4aS,6aS,6bR,8aR,14aR,14bR,16bS)-2,2,6a,6b,9,9,14a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-hexadecahydrochryseno[1,2-g]quinoxaline-4a(2H)-carboxylic acid
-
-
(5R,7R,8R,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene-8,9,10-triol
P00489
-
(5R,7R,8R,9S,10R)-7-(hydroxymethyl)-3-(4-methoxyphenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene-8,9,10-triol
P00489
-
(5R,7R,8R,9S,10R)-7-(hydroxymethyl)-3-(4-toluyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene-8,9,10-triol
P00489
-
(5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione
-
-
(5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane 2,2-dioxide
-
-
(5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(naphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane 2,2-dioxide
-
-
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
-
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
-
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(naphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
-
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one
-
-
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione
-
-
(6aS,6bR,8aR,16aR,16bR,18bS)-2,2,6a,6b,9,9,16a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,16,16a,16b,17,18b-hexadecahydrochryseno[1,2-b]phenazine-4a(2H)-carboxylic acid
-
-
(NH4)2SO4
-
50-300 mM, weak inhibition
1'-(methylsulfonyl)pyrazolo[4,3-b]olean-12-en-28-oic acid
-
-
-
1'-acetylpyrazolo[4,3-b]olean-12-en-28-oic acid
-
-
-
1'-propanoylpyrazolo[4,3-b]olean-12-en-28-oic acid
-
-
-
1,3,5-tris-4'-2''-[3'''-C-(beta-D-glucopyranosyl)-1''',2''',4'''-oxadiazol-5'''-yl]ethyl-1',2',3'-triazol-1'-ylmethylbenzene
-
trivalent inhibitor. The valency of the molecules influences slightly the inhibition of the enzyme whereas the presence of a spacer arm between the core and the pharmacophore moieties does not
1,3,5-tris[3'-C-(beta-D-glucopyranosyl)-1',2',4'-oxadiazol-5'-yl]-benzene
-
trivalent inhibitor. The valency of the molecules influences slightly the inhibition of the enzyme whereas the presence of a spacer arm between the core and the pharmacophore moieties does not
1,4-dideoxy-1,4-imino-D-arabinitol
-
inhibits Pa-catalyzed As(V) reduction, inhibition of As(V) reduction is not influenced by glucose or AMP
1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-methylidene-D-glucitol
-
-
1,5-gluconolactone
-
strong inhibition of muscle isozyme a and b
1-(2-carboxyphenyl)-6-[(2-chloro-4,6-difluorophenyl)amino]-4-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid
-
i.e. AVE9423. Inhibitor fully exploits the volume of the binding pocket and show pronounced binding entropy
1-(2-carboxyphenyl)-6-[(2-chloro-4,6-difluorophenyl)amino]-4-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid
-
-
1-(beta-D-glucopyranosyl)-4-hydroxymethyl-1,2,3-triazole
-
-
1-(beta-D-glucopyranosyl)-4-phenyl-1,2,3-triazole
-
-
1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)uracil
-
-
1-(beta-D-glucopyranosyl)-5-(pent-1-yn-1-yl)uracil
-
-
1-(beta-D-glucopyranosyl)-5-ethynyluracil
-
cytotoxic effect on Hep-G2 cells
1-(beta-D-glucopyranosyl)-5-iodouracil
-
-
1-deoxy-1-methoxycarbonylamino-beta-D-glucopyranose
-
-
1-methyl-3-([4-(2-thienylmethyl)phenyl]amino)quinoxalin-2(1H)-one
-
50% inhibition at 0.00011 mM in glycogenolysis assay, no bioavailability in vivo
1-[(2S)-2-([(5-chloro-1H-indol-2-yl)carbonyl]amino)-3-phenylpropanoyl]azetidine-3-carboxylic acid
-
i.e. CP-403700, 50% inhibition at 0.1 microM in presence of 1 mM phosphate. In presence of 1 mM phosphate plus 8 mM glucose, 50% inhibition at 0.05 microM. Presence of endogenous inhibitors such as D-glucose, ADP, ATP, D-fructose 1-phosphate, D-glucose 6-phosphate, UDP-glucose markedly reduces the inhibitory effect
1-[(2S)-2-([(5-chloro-1H-indol-2-yl)carbonyl]amino)-3-phenylpropanoyl]azetidine-3-carboxylic acid
-
i.e. CP-403700, indole-site inhibitor, suppression of hepatic glycogenolysis
1-[2-([[(2-chloro-4,5-difluorophenyl)carbonyl]carbamoyl]amino)-4-fluorophenyl]piperidine-4-carboxylic acid
-
i.e. AVE2865. Inhibitor fully exploits the volume of the binding pocket and show pronounced binding entropy
1-[2-([[(2-chloro-4,5-difluorophenyl)carbonyl]carbamoyl]amino)-4-fluorophenyl]piperidine-4-carboxylic acid
-
-
1-[6-(acetyloxy)hexyl] 4-(7-[[(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy]heptyl) (2R)-2-hydroxybutanedioate
-
-
1-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]cyclodecanecarboxylic acid
-
-
1-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]cyclooctanecarboxylic acid
-
potent in vitro inhibition, reduced inhibition of CYP2C9 and good pharmacokinetic properties
2,2',2''-tris[(2E)-4-hydroxybut-2-en-1-yl] 1,1',1''-(3b,5x,9x,13x,18x)-lup-20(29)-ene-3,23,28-triyl triethanedioate
-
-
2,3,4,6-tetra-O-acetyl-1-O-[(2alpha,3beta)-2,3-dihydroxy-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-(hydroxymethyl)-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-(iodomethyl)-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-({[(4-methylphenyl)sulfonyl]oxy}methyl)-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-({[2-(1H-indol-3-yl)ethyl]amino}methyl)-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-methyl-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-[(chlorooxy)methyl]-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-[(hydroxyamino)methyl]-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-[(naphthalen-2-ylamino)methyl]-alpha-D-glucopyranose
-
-
-
2,3,4,6-tetra-O-benzyl-1-C-[(pyridin-2-ylamino)methyl]-alpha-D-glucopyranose
-
-
2,3,4,6-tetra-O-benzyl-1-C-{[(4-methoxyphenyl)amino]methyl}-alpha-D-glucopyranose
-
-
2,3-dichloro-N-(1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.002 microM
2,3-dichloro-N-(1-[3-hydroxy-2-(hydroxymethyl)propyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.038 microM
2,3-dichloro-N-[1-(2-hydroxyethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.007 microM
2,3-dihydroisooxazolyl oleanolic acid benzyl ester
-
50% inhibition at 0.0196 mM
2,3-diphosphoglycerate
-
5 mM, 30% inhibition
2,4-Dinitrophenol
-
5 mM, 67% inhibition
2-(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)-4-methoxybutanoic acid
-
-
2-(phenylamino)ethyl (3beta)-3-hydroxyurs-12-en-28-oate
-
-
2-amino-3,4-dihydroxy-5-methoxybenzoic acid
-
-
2-amino-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-N-(3-trifluoromethyl-phenyl)-benzamide
P00489
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-amino-4-fluoro-N-(3-fluoro-phenyl)-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide
P00489
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-amino-4-fluoro-N-(4-methoxy-phenyl)-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide
P00489
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-amino-N-(3-amino-phenyl)-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide
P00489
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-amino-N-(3-cyano-phenyl)-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide
P00489
simultaneous inhibition of glycogen phosphorylase and activation of glucokinase
2-bromoethyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
2-bromoethyl (3beta)-3-hydroxyurs-12-en-28-oate
-
-
2-chloro-N-((3R)-1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.040 microM
2-chloro-N-((3R)-1-[(2S)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.021 microM
2-chloro-N-((3S)-1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.027 microM
2-chloro-N-((3S)-1-[(2S)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.012 microM
2-chloro-N-(1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.029 microM
2-chloro-N-(1-[2-(methylsulfinyl)ethyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.048 microM
2-chloro-N-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.041 microM
2-chloro-N-[1-(2-hydroxybutyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.044 microM
2-chloro-N-[1-(2-hydroxyethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.026 microM
2-chloro-N-[1-(2-methoxyethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.05 microM
2-chloro-N-[1-(3-hydroxypropyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.021 microM
2-chloro-N-[1-(cyanomethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.028 microM
2-Cresol
-
5 mM, 67% inhibition
2-ethoxy-2-oxoethyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
2-ethoxy-2-oxoethyl (2beta,3alpha,5xi,8alpha,9xi,10alpha,14beta,17alpha,18alpha)-2,3-dihydroxyolean-12-en-28-oate
-
50% inhibition at 0.019 mM
2-ethylimidazole
-
weak inhibition of wild-type activity, inhibition of mutant enzyme H334G
2-hydroxymethenyl oleanonic acid benzyl ester
-
50% inhibition at 0.0063 mM
2-methylimidazole
-
weak inhibition of wild-type activity
2-O-acetyl-3-oxomaslinic acid benzyl ester
-
50% inhibition at 0.029 mM
2-oxours-12-en-28-oic acid
-
-
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl (1S,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-(acetyloxy)-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
-
-
2-[(2R)-3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-(acetyloxy)-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
-
-
2-[3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl]-N-(3'',4''-dichlorobenzyl)acetamide
-
-
2beta,3alpha-dihydroxyurs-12-en-28-oic acid
-
-
3,5-dinitrobenzoic acid
-
5 mM, 47% inhibition
3-(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)propanoic acid
-
-
3-(beta-D-glucopyranosyl)-6-pentyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one
-
-
3-(beta-D-glucopyranosyl)-6-propyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one
-
-
3-Aminophenol
-
5 mM, 20% inhibition
3-methoxypterolactone
-
-
3-Nitrophenol
-
5 mM, 83% inhibition
3-O-[1-(methyl 6-deoxy-alpha-D-glucopyranosid-6-yl)-1H-1,2,3-triazol-4-yl]methyl 3b-hydroxyolean-12-en-28-oate
P00489
inhibitor is predicted to bind at the T-state allosteric site exclusively. The binding position of the oleanolic acid moiety occupies the same location as the T-state allosteric site of asiatic acid in the crystal structure. The newly attached sugar moiety shields the carboxyl group of oleanolic acid from forming the salt bridge with Arg310, and consequently reverses the orientation of the oleanolic acid as well as propelled the sugar moiety to extend more deeply into the alloteric dimer interface. As a result, a new hydrogen-bonding network forms between the sugar hydroxyls and the carboxyl of Asp227 plus the guanidino of Arg193, respectively, enhancing their contribution to the stability of the complex
3-[(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)amino]-3-oxopropanoic acid
-
-
3-[(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)oxy]propanoic acid
-
-
3-[(4-isoxazolidin-3-ylphenyl)amino]-1-methylquinoxalin-2(1H)-one
-
50% inhibition at 0.00011 mM in glycogenolysis assay, no bioavailability in vivo
4-(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)butanoic acid
-
-
4-([[(2-chloro-4,5-difluorophenyl)carbonyl]carbamoyl]amino)-3-(trifluoromethoxy)benzoic acid
-
i.e. AVE5688, binding to enzyme is exclusively enthalpic
4-([[(2-chloro-4,5-difluorophenyl)carbonyl]carbamoyl]amino)-3-(trifluoromethoxy)benzoic acid
-
-
4-Cresol
-
5 mM, 67% inhibition
4-hydroxy-3-methoxybenzoic acid
-
-
4-nitrophenol
-
5 mM, 56% inhibition, enhances inhibition by glucose, glucose-6-phosphate and ATP
4-oxo-4-[(pyrazolo[4,3-b]olean-12-en-28-yl)oxy]butanoic acid
-
-
4-S-alpha-D-glucopyranosyl-4-thiomaltotetraose
-
-
4-[(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)amino]-N-(2-thienylmethyl)benzamide
-
50% inhibition at 0.00014 mM in glycogenolysis assay, no bioavailability in vivo
4-[[(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)methyl]sulfonyl]butanoic acid
-
-
5-(beta-D-glucopyranosyl)-3-(2-naphthyl)-1,2,4-oxadiazole
-
-
5-(beta-D-glucopyranosyl)-3-(4-methylphenyl)-1,2,4-oxadiazole
-
-
5-chloro-N-(1,3,6,6-tetrafluoro-(R)-5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
docking study. Hydrophobic residues, such as Phe53, Pro188, and Gly186, around the two aliphatic fluorine atoms suggest that the lipophilic contact among them is an important driver of activity increases. Hydrophobic residues Leu39 and Lys191 are close to one of the aromatic fluorine atoms
5-chloro-N-(1,6,6-trifluoro-5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-(1-hydroxy-2,3-dihydro-1H-inden-5-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-(1-[(2R)-2,3-dihydroxypropyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)-1H-indole-2-carboxamide
-
50% inhibition at 0.044 microM
5-chloro-N-(3,6,6-trifluoro-5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-(5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-(6,6-difluoro-5-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-indole-2-carboxamide
-
-
5-chloro-N-[1-(2-hydroxyethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-1H-indole-2-carboxamide
-
50% inhibition at 0.017 microM
5-chloro-N-[2-chloro-4-(1,2-dihydroxyethyl)-phenyl]-1H-indole-2-carboxamide
-
-
5-chloro-N-[4-(1,2-dihydroxyethyl)-3-(trifluoromethyl)phenyl]-1H-indole-2-carboxamide
-
-
5-chloro-N-[4-(1,2-dihydroxyethyl)phenyl]-1H-indole-2-carboxamide
-
crystallization data
5-chloro-N-[4-(1,2-dihydroxyethyl)phenyl]-1H-indole-2-carboxamide
-
inhibitor shows oral hypoglycemic activity in diabetic db/db mice
5-chloro-N-[4-(2-hydroxyethyl)phenyl]-1H-indole-2-carboxamide
-
-
5-chloro-N-[5-(1,2-dihydroxyethyl)pyrazin-2-yl]-1H-indole-2-carboxamide
-
-
5-chloro-N-[5-(1,2-dihydroxyethyl)pyridin-2-yl]-1H-indole-2-carboxamide
-
-
6-(butylamino)hexyl (3beta)-3-hydroxyolean-12-en-28-oate
-
-
6-aminohexyl (3beta)-3-hydroxyolean-12-en-28-oate
-
-
6-hydroxyluteolin
-
-
6-[(4-methylphenyl)amino]hexyl (3beta)-3-hydroxyolean-12-en-28-oate
-
-
6-[4-(methyl 2,3,4-tri-O-benzyl-alpha-D-glucopyranosiduronylmethyl)-1H-1,2,3-triazol-1-yl]hexyl 3beta-hydroxyolean-12-en-28-oate
P00489
-
acarbose
-
poor inhibition
acetate
-
weak inhibition of wild-type activity, no effect on the activity of the H334G mutant
ADP
-
1.6 mM, 50% inhibition of starch phosphorolysis, 0.23 mM, 50% inhibition of starch synthesis, allosteric inhibition, kinetics
ADP
-
5 mM, 8% inhibition of glucan phosphorolysis
ADP
-
at physiological levels diminishes GPa-catalyzed As(V) reduction
ADP-glucose
-
strong inhibition
ADP-glucose
-, Q2VA40, Q2VA41
maximal inhibition achieved is 70%; maximal inhibition achieved is 95%
ADP-glucose
Q9ATK9
2fold inhibition at 4 mM
ADPglucose
Gracilaria sordida
-
-
ADPglucose
-
competitive inhibition
ADPglucose
-
competitive inhibition
ADPglucose
-
reversible by Mg2+
ADPglucose
-
kinetics
ADPglucose
-
5 mM, 30% inhibition
ADPglucose
-
4 mM, 60% inhibition of chloroplast phosphorylase
ADPglucose
-
1.3 mM, 50% inhibition of phosphorylase II, glucan phosphorolysis; strong inhibition of phosphorolysis, isozyme I
ADPglucose
-
weak inhibition
ADPglucose
-
strong inhibition
ADPglucose
-
2.5 mM, 80% inhibition of stromal phosphorylase
Ag+
-
strong inhibition
Ag+
-
2 mM, 78% inhibition
Ag+
-
1 mM, complete inhibition
Al3+
Q9ATK9
-
alpha-Amylose
-
-
-
alpha-boswellic acid
-
-
alpha-cyclodextrin
-
mixed-type competitive inhibition, inhibitor is not bound into the enzyme crystal
alpha-cyclodextrin dialdehyde I
-
5 mM, 50% inhibition after 131 min
-
alpha-cyclodextrin dialdehyde I
-
0.4 mM, 50% inhibition after 15 min, 1.6 mM, 50% inhibition after 4.7 min
-
alpha-cyclodextrin dialdehyde II
-
5 mM, 50% inhibition after 30 min
-
alpha-D-Glucopyranose-1,2-cyclic phosphate
-
competitive vs. glucose 1-phosphate
alpha-D-glucopyranosyl fluoride
-
strong inhibition of phosphorylase b, kinetics; weak inhibition
alpha-D-glucopyranosyl fluoride
-
weak inhibition
alpha-D-glucose
-
physiological inhibitor
alpha-D-glucose 6-phosphate
-
binds at the allosteric site
alpha-D-glucose-1-methylenephosphonate
-
competitive vs. glucose 1-phosphate
alpha-methylglucoside
-
-
AMP
-
reversible by Mg2+; weak
AMP
-
isozyme a; weak
AMP
-
10 mM, 55% inhibition, competitive to glucose 1-phosphate
AMP
-
1-20 mM, weak inhibition
AMP
-
slight inhibition
Aniline
-
5 mM, 50% inhibition
Antibodies to skeletal muscle phosphorylase
-
heart enzyme
-
Antiserum of purified phosphorylase
-
-
-
aromatic amino acid
-
-
-
aromatic amino acid
-
inhibition of phosphorylase B, not A or C
-
aromatic amino acid
-
-
-
ATP
-
less effective than nucleotide sugars
ATP
-
rabbit muscle enzyme
ATP
-
2.9 mM, 50% inhibition of starch phosphorolysis, 1.4 mM, 50% inhibition of starch synthesis
ATP
-
1 mM, 20% inhibition of phosphorylase B, 5 mM, 90% inhibition; phosphorylase A or C are not inhibited
ATP
-
1 mM, 50% inhibition, at non-saturating levels of glucose 1-phosphate; additive inhibition together with tyrosine
ATP
-
complete inhibition of heart phosphorylase IIIb
ATP
-
5 mM, 10% inhibition of glucan phosphorolysis
ATP
-
at physiological levels diminishes GPa-catalyzed As(V) reduction
ATP
Q9ATK9
slight inhibtiion
azide
-
weak inhibition of wild-type activity
baicalein
-
50% inhibition of phosphorylated, active enzyme at 0.0112 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0102 mM
BAY U6751
-
inhibits Pa-catalyzed As(V) reduction, glucose enhances inhibitory effect of the inhibitor on As(V) reduction, AMP at high concentration alleviates the inhibition
benzyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
benzyl (2beta)-2-hydroxyurs-12-en-28-oate
-
-
benzyl (2beta,3alpha)-2,3-dihydroxyolean-12-en-28-oate
-
-
benzyl (2beta,3alpha)-2,3-dihydroxyurs-12-en-28-oate
-
-
benzyl (2beta,5xi,8alpha,9xi,10alpha,14beta,17alpha,18alpha)-2-hydroxy-3-oxoolean-12-en-28-oate
-
50% inhibition at 0.029 mM
benzyl (2Z)-2-(hydroxyimino)olean-12-en-28-oate
-
-
benzyl (2Z)-2-(hydroxyimino)urs-12-en-28-oate
-
-
benzyl (2Z,5xi,8alpha,9xi,10alpha,14beta,17alpha,18alpha)-2-[[(2,4-dichlorobenzyl)oxy]imino]-3-oxoolean-12-en-28-oate
-
50% inhibition at 0.008 mM
benzyl (3beta)-3-[(pyridinium-1-ylacetyl)oxy]olean-12-en-28-oate chloride
-
-
benzyl (3beta)-3-[([4-[(4-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl]phenoxy)methyl]-1H-1,2,3-triazol-1-yl]acetyl)oxy]olean-12-en-28-oate
-
-
benzyl (3beta)-3-[([4-[(dodecanoyloxy)methyl]-1H-1,2,3-triazol-1-yl]acetyl)oxy]olean-12-en-28-oate
-
-
benzyl (3beta)-3-[[(4-[[(phenylacetyl)oxy]methyl]-1H-1,2,3-triazol-1-yl)acetyl]oxy]olean-12-en-28-oate
-
-
benzyl (3beta,12alpha,13xi)-3,12-dihydroxyoleanan-28-oate
-
-
benzyl (3beta,12beta,13xi)-3,12-dihydroxyoleanan-28-oate
-
-
benzyl (5xi,8alpha,9xi,10alpha,14beta,17alpha,18alpha)-2-hydroxy-3-oxooleana-1,12-dien-28-oate
-
50% inhibition at 0.030 mM
benzyl 1'-(2,4-dichlorobenzyl)pyrazolo[4,3-b]olean-12-en-28-oate
-
-
-
benzyl 1'-(carboxymethyl)pyrazolo[4,3-b]olean-12-en-28-oate
-
-
-
benzyl 1'-benzylpyrazolo[4,3-b]olean-12-en-28-oate
-
-
-
benzyl 1'-methylpyrazolo[4,3-b]olean-12-en-28-oate
-
-
-
benzyl 1'-[(ethoxycarbonyl)methyl]pyrazolo[4,3-b]olean-12-en-28-oate
-
-
-
benzyl 2-oxoolean-12-en-28-oate
-
-
benzyl 2-oxours-12-en-28-oate
-
-
benzyl 3-O-propargyl-3beta-hydroxyolean-12-en-28-oate
P00489
-
benzyl 3beta-(2-(diethylamino)acetoxy)olean-12-en-28-oate
-
-
benzyl 3beta-(2-azidoacetoxy)olean-12-en-28-oate
-
-
benzyl 3beta-(2-chloroacetoxy)olean-12-en-28-oate
-
-
benzyl 3beta-(4-aminobenzoyloxy)olean-12-en-28-oate
-
-
benzyl 3beta-(4-nitrobenzoyloxy)olean-12-en-28-oate
-
-
benzyl pyrazolo[4,3-b]olean-12-en-28-oate
-
-
beta-amylase
-
noncompetitive vs. glucose 1-phosphate
-
beta-amylase
-
-
-
beta-Amylose
-
-
beta-amyrin
-
-
beta-amyrone
-
-
beta-boswellic acid
-
-
beta-cyclodextrin
-
mixed-type competitive inhibition, the inhibitor can be accomodated in the glycogen storage site of T-state enzyme, subsite specificity
beta-D-glucopyranosyl 1-(2-cyclopropylamino-2-oxoacetyl)-amide
-
competitive
beta-D-glucopyranosyl 1-(ethoxy(oxo)acetyl)-amide
-
competitive
beta-D-glucopyranosyl 1-(methoxy(oxo)acetyl)-amide
-
competitive
beta-D-glucopyranosyl 1-oxalylamide
-
competitive
beta-D-glucopyranosyl bismethoxyphosphoramidate
-
weak competitive inhibitor, binds at the catalytic site and induces conformational changes in the vicinity of the site, inhibition mechanism, overview
beta-O-trans-caffeoyl-morolic acid
-
-
bis(6-([(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy)hexyl) (2R)-2-hydroxybutanedioate
-
-
bredemolic acid
-
allosteric site inhibitor
butyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
Ca2+
-
1 mM, stimulation at 10 mM
Caffeine
-
strong inhibition of muscle enzyme
Caffeine
-
5 mM, 95% inhibition of heart phosphorylase Ib in the presence of 1 mM AMP, 30% inhibition of heart phosphorylase IIb
Caffeine
-
5 mM, complete inhibition of phosphorylase b, strong inhibition of phosphorylases ab and a
cAMP
-
5 mM, weak inhibition
chrysin
-
50% inhibition of phosphorylated, active enzyme above 0.0275 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0153 mM
Cl-
-
weak inhibition
Co2+
-
1 mM, no inhibition at 10 mM
Co2+
Q9ATK9
-
CP-316819
-
indole-site inhibitor, presence of endogenous inhibitors such as D-glucose, ADP, ATP, D-fructose 1-phosphate, D-glucose 6-phosphate, UDP-glucose markedly reduces the inhibitory effect
CP-316819
-
indole-site inhibitor, oral administration to diabetic ob/ob mice results in lowering of plasma glucose concentration by 40% at 50 mg per kg. Measured drug concentration in the liver is about 100fold higher than the in vitro IC50 values
CP-316819
-
indole-site inhibitor, suppression of hepatic glycogenolysis
CP-320626
-
indole-site inhibitor, presence of endogenous inhibitors such as D-glucose, ADP, ATP, D-fructose 1-phosphate, D-glucose 6-phosphate, UDP-glucose markedly reduces the inhibitory effect
CP-320626
-
indole-site inhibitor, suppression of hepatic glycogenolysis
CP-320626
-
-
CP-380867
-
indole-site inhibitor, presence of endogenous inhibitors such as D-glucose, ADP, ATP, D-fructose 1-phosphate, D-glucose 6-phosphate, UDP-glucose markedly reduces the inhibitory effect
-
CP-380867
-
indole-site inhibitor, suppression of hepatic glycogenolysis
-
CP320626
-
hypoglycaemic drug, potent inhibitor of liver and muscle glycogen phosphorylase a
CP320626
-
inhibits Pa-catalyzed As(V) reduction, glucose enhances inhibitory effect of the inhibitor on As(V) reduction, AMP at high concentration alleviated the inhibition
CTP
Q9ATK9
slight inhibtiion
Cu2+
-
1 mM, strong inhibition
Cu2+
-
2 mM, 98% inhibition
Cu2+
-
10 mM, complete inhibition
Cu2+
-
4 mM, more than 50% inhibition
Cu2+
-
2 mM, 73% inhibition
Cu2+
Q9ATK9
-
cyanidin
-
50% inhibition of phosphorylated, active enzyme at 0.003 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.009 mM
Cyclodextrin
-
alpha- or beta-, not gamma-cyclodextrin; i.e. structure analogue of alpha-1,4-linked starch molecule
-
Cyclodextrin
-
i.e. structure analogue of alpha-1,4-linked starch molecule; weak inhibition
-
Cyclodextrin
-
i.e. structure analogue of alpha-1,4-linked starch molecule; strong inhibition
-
Cyclodextrins
-
-
-
cyclohexaamylose
Gracilaria sordida
-
-
cysteine
-
1 mM, 86% inhibition
D-Fructose 1-phosphate
-
-
D-fructose 6-phosphate
-
strong inhibition
D-gluconic acid 1,5-lactone
-
-
D-glucono-delta-lactone
-
0.05 mM, 90% inhibition of glucan phosphorolysis
D-glucose
-
non-competitive
D-glucose
-
5 mM and 8.5 mM, 50% inhibition of phosphorylase ab at 8 mM and 16 mM glucose 1-phosphate, 23 mM and 40 mM, 50% inhibition of phosphorylase a
D-glucose
-
1 mM, significant inhibition of kidney dephosphophosphorylase
D-glucose
-
50 mM, 30% inhibition of glucan phosphorolysis
D-glucose
-
-
D-glucose 6-phosphate
-
-
D-mannose 1-phosphate
-
strong inhibition
delphinidin
-
50% inhibition of phosphorylated, active enzyme at 0.0031 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0107 mM
Deoxypyridoxine
-
weak inhibition of phosphorylase I, not II
diethyldicarbonate
-
0.84 mM, 50% inhibition
diethyldithiocarbamate
-
1 mM, 94% inhibition
dithiothreitol
-
1 mM, 56% inhibition
DL-phenylalanine
-
1 mM, 33% inhibition of phosphorylase B
DL-tryptophan
-
1 mM, 41% inhibition of phosphorylase B
EDTA
-
1 mM, 61% inhibition
EDTA
-
10 mM, 88% inhibition
EDTA
-
slight activation
EGTA
-
i.e. ethylene glycol bis(beta-aminoethylether)-N,N'-tetraacetic acid, 1 mM, 53% inhibition
Ellagic acid
-
50% inhibition of phosphorylated, active enzyme at 0.0032 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0121 mM
Epicatechin gallate
-
50% inhibition of phosphorylated, active enzyme at 0.0125 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.050 mM
epigallocatechin-3-gallate
-
50% inhibition of phosphorylated, active enzyme at 0.0077 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0339 mM
ethyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
Fe2+
-
weak inhibition
-
Fe2+
-
2 mM, 60% inhibition in the presence of 1 mM AMP
-
Fe2+
-
10 mM, stimulation at 1 mM
-
Fe2+
-
2 mM, 73% inhibition
-
Fe2+
-
1 mM, approx. 40% inhibition of synthesis
-
Fe2+
Q9ATK9
-
-
formate
-
5fold reduction of wild-type activity, no effect on the activity of the H334G mutant
FR258900
-
the inhibitor binds at the allosteric activator site, where the physiological activator AMP binds. The contacts from FR258900 to glycogen phosphorylase are dominated by nonpolar van der Waals interactions with Gln71, Gln72, Phe196, and Val459 (from the symmetry-related subunit), and also by ionic interactions from the carboxylate groups to the three arginine residues (Arg242, Arg309, and Arg310) that form the allosteric phosphate-recognition subsite. The binding of FR258900 to the protein promotes conformational changes that stabilize an inactive T-state quaternary conformation of the enzyme
fructose 1-phosphate
-
-
fructose 6-phosphate
-
-
fructose 6-phosphate
-
-
fructose 6-phosphate
-
weak
fructose 6-phosphate
-
-
Gallic acid
-
-
gamma-cyclodextrin
-
mixed-type competitive inhibition, the inhibitor can be accomodated in the glycogen storage site of T-state enzyme, subsite specificity
GDPglucose
-
kinetics
GDPglucose
-
0.05 mM, 50% inhibition, competitive inhibition of phosphorolysis
glucopyranosylidene spirohydantoin
-
most effective glucose analogue inhibitor for glycogen phosphorylase b
glucopyranosylidene spirothiohydantoin
-
muscle and liver phosphorylase b, strong competitive inhibiton vs. phosphate and glycogen
glucose
-
above 5 mM, diminishes GPa-catalyzed As(V) reduction
glucose 1-phosphate
-
above 2 mM; substrate inhibition
glucose 1-phosphate
-
not inhibited
glucose 1-phosphate
-
completely reversible by 5'-AMP; kinetics
glucose 1-phosphate
-
kinetics
glucose 1-phosphate
-
-
glucose 1-phosphate
-
not inhibited
glucose 2-phosphate
-
weak
glucose 6-phosphate
-
-
glucose 6-phosphate
-
-
glucose 6-phosphate
-
-
glucose 6-phosphate
-
-
glucose 6-phosphate
-
above 5 mM
glucose 6-phosphate
-
5 mM, 54% inhibition
glucose 6-phosphate
-
weak inhibition
glucose 6-phosphate
-
complete inhibition of heart phosphorylase IIIb
glucose 6-phosphate
-
-
glucose 6-phosphate
-
-
glucose 6-phosphate
-
-
GTP
Q9ATK9
slight inhibtiion
guanidine hydrochloride
-
study on kinetics of inactivation and aggregation at 0.7 M guanidine hydrochloride. Osmolytes trimethylamine-N-oxide and betaine exhibit the highest protective efficacy against phosphorylase b inactivation
hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyl) (3beta,3'beta)-bis(3-hydroxyolean-12-en-28-oate)
-
-
Hg2+
-
1 mM, strong inhibition
Hg2+
-
4 mM, more than 50% inhibition
Hg2+
-
0.05 mM, 21% inhibition of phosphorylase A, 73% inhibition of phosphorylase
Hg2+
-
2 mM, complete inhibition
Hg2+
-
0.1 mM, complete inhibition
Hg2+
-
1 mM, complete inhibition
Hg2+
-
1 mM, 77% inhibition of stromal phosphorylase
Hg2+
Q9ATK9
-
High salt concentration
-
-
-
hydrogencarbonate
-
weak inhibition
imidazole
-
weak inhibition of wild-type enzyme
iminobis[ethane-2,1-diylimino(3beta)-28-oxoolean-12-ene-28,3-diyl]diacetate
-
-
IMP
-
slight inhibition
iodoacetamide
-
weak
iodoacetate
-
weak inhibition
iodoacetate
-
weak inhibition
isoscullarein
-
-
KCl
-
80 mM, 50% loss of activity, 200 mM, 90% loss of activity
L-tyrosine
-
noncompetitive inhibition
L-tyrosine
-
1 mM, 48% inhibition of phosphorylase B
L-tyrosine
-
additive inhibition together with ATP
luteolin
-
50% inhibition of phosphorylated, active enzyme at 0.0156 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0288 mM
maslinic acid
-
50% inhibition at 0.028 mM
maslinic acid 5-bromopentyl ester
-
50% inhibition at 0.007 mM
maslinic acid-(2-piperidin-1-yl)ethyl ester
-
50% inhibition at 0.031 mM
methyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
methyl (2S)-[[(2alpha,3beta)-2,3-bis(acetyloxy)-28-oxours-12-en-28-yl]amino](4-hydroxyphenyl)ethanoate
-
-
methyl (2S)-[[(2alpha,3beta)-2,3-bis(acetyloxy)-28-oxours-12-en-28-yl]amino](phenyl)ethanoate
-
-
methyl 6-deoxy-6-[4-([[(3beta)-3-hydroxy-28-oxoolean-12-en-28-yl]oxy]methyl)-1H-1,2,3-triazol-1-yl]-alpha-D-glucopyranoside
-
-
methyl [3-([(2-chloro-6H-thieno[2,3-b]pyrrol-5-yl)carbonyl]amino)-2-oxo-3,4-dihydroquinolin-1(2H)-yl]acetate
-
50% inhibition at 0.084 microM
Mg-ATP
-
reversible by AMP
Mn2+
-
reaction without glucan primer
Mn2+
-
strong inhibition at 1 mM
molybdate
-
5 mM, more than 50% inhibition of glucan phosphorolysis
monohydroxyphenols
-
10 mM, 50, 40 and 65% inhibition of phosphorylases A, B and C
-
N-(3-carboxypropanoyl)-beta-D-glucopyranosylamine
-
-
N-(3-cyano-phenyl)-2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-acetamide
P00489
-
N-(3-fluoro-phenyl)-2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-acetamide
P00489
-
N-(acetylcarbamoyl)-beta-D-glucopyranosylamine
-
-
N-(azidoacetyl)-beta-D-glucopyranosylamine
-
-
N-(benzoylcarbamoyl)-beta-D-glucopyranosylamine
-
-
N-(dimethoxyphosphoryl)-beta-D-glucopyranosylamine
-
-
N-(naphthalen-2-ylcarbonyl)-beta-D-glucopyranosylamine
-
-
N-(trifluoroacetyl)-beta-D-glucopyranosylamine
-
-
N-([(2E)-2-[4-(trifluoromethyl)benzylidene]hydrazinyl]carbonothioyl)-beta-D-glucopyranosylamine
-
-
N-([4-[(benzyloxy)carbonyl]benzoyl]carbamoyl)-beta-D-glucopyranosylamine
-
-
N-acetyl-beta-D-glucopyranosylamine
-
-
N-Acetylimidazole
-
glucose 1-phosphate prevents
N-benzyl-2-[3'-(benzylamino)-2'-oxopyridin-1'(2H)-yl]acetamide
-
-
N-carbamoyl-beta-D-glucopyranosylamine
-
-
N-ethylmaleimide
-
weak
N-phenyl-beta-D-glucopyranosylamine
-
-
N-[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]-L-norleucine
-
potent in vitro inhibition, low potential for P450 inhibition, and good pharmacokinetic properties
N-[(4-aminobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-carboxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-carboxybenzoyl)carbamoyl]-beta-D-glucopyranosylamineN-acetyl-beta-D-glucopyranosylamine
-
-
-
N-[(4-chlorobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-hydroxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-methoxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-methylbenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(4-nitrobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[(biphenyl-4-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine
-
-
N-[1-(2-amino-2-oxoethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-2-methyl-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
50% inhibition at 0.135 microM
N-[1-(2-amino-2-oxoethyl)-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl]-2-methyl-6H-thieno[2,3-b]pyrrole-5-carboxamide
-
-
N-[methoxy(oxo)acetyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(2-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(2-nitrobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(3-bromobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(3-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(3-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-bromobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-fluorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-methoxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-methylbenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(4-nitrobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[(2E)-2-(pyridin-4-ylmethylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
-
N-[[4-(methoxycarbonyl)benzoyl]carbamoyl]-beta-D-glucopyranosylamine
-
-
Na2SO4
-
50-300 mM, weak inhibition
NADPH
-
also oxidized form, less effective than nucleotide sugars, not NAD(H)
NaF
-
200 mM, complete inhibition
NaHSO3
-
kinetics, completely reversible by dilution or dialysis
NaNO3
-
strong inhibition
NEM
-
inhibits GPa-catalyzed As(V) reduction
O-(1-methylcyclopentyl)-N-[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]-L-allothreonine
-
-
O-tert-butyl-N-[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]-L-allothreonine
-
potent in vitro inhibition, low potential for P450 inhibition, and good pharmacokinetic properties
O-tert-butyl-N-[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]-L-serine
-
potent in vitro inhibition, low potential for P450 inhibition, and good pharmacokinetic properties
oleanolic acid
-
50% inhibition at 0.014 mM
oleanolic acid
-
-
oleanolic acid
-
a naturally existing pentacyclic triterpene
oleanolic acid 3-O-[(2E)-3-(4-chlorophenyl)acrylic acid] ester
-
50% inhibition at 0.0033 mM
oleanolic acid 3-O-[(2E)-3-(4-methoxyphenyl)acrylic acid] ester
-
50% inhibition at 0.0169 mM
oleanonic acid
-
50% inhibition at 0.0179 mM
oleanonic acid 2,3-oxadiazole
-
50% inhibition at 0.0112 mM
oleanonic acid 3-oxime
-
50% inhibition at 0.0208 mM
p-chloromercuribenzene sulfonate
-
inhibits GPa-catalyzed As(V) reduction
p-chloromercuribenzoate
-
1 mM, 55% inhibition
p-chloromercuribenzoate
-
0.5 mM, 60% inhibition, reversible by 10 mM 2-mercaptoethanol
p-chloromercuribenzoate
-
-
p-Chloromercuriphenylsulfonic acid
-
1 mM, 88% inhibition of stromal phosphorylase
p-hydroxymercuribenzoate
-
2 mM, 96% inhibition
p-hydroxymercuribenzoate
-
glucose 1-phosphate prevents
pelargonidin
-
50% inhibition of phosphorylated, active enzyme at 0.0436 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0062 mM
peonidin
-
50% inhibition of phosphorylated, active enzyme at 0.0251 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0176 mM
peroxynitrite
-
the peroxynitrite-dependent inactivation of the enzyme could be due to the nitration of Tyr613, a key amino acid of the allosteric inhibitor site of the enzyme. Glycogen phosphorylase functions may be regulated by tyrosine nitration
peroxynitrite
P00489
1 mM, almost complete inactivation. After the exposure to 1 mM peroxynitrite, the molar content of Cys residues decreases from 8.63 to 3.43 and 4.24 in the absence and in the presence of bicarbonate, respectively. The addition of 1 mM DTT in 10 min after peroxynitrite treatment does not significantly reverse loss of either activity or molar content of DTNB-reactive Cys residues. No involvement of Tyr613 nitration in the control of enzymatic function. The enzymatic activity does not directly correlate with the protein nitration levels
Phenol
-
5 mM, 45% inhibition
Phenylglyoxal
-
12 mM, 50% inhibition
phosphate
-
-
phosphate
Q9ATK9
Pho1 activity is strongly competitively inhibited by product phosphate in the synthesis reaction when amylopectin is the primer substrate, but this inhibition is less pronounced when short alpha-glucan chains are used as primers
phosphoenol pyruvate
Q9ATK9
slight inhibtiion
-
phosphoenolpyruvate
-
-
Phosphorylase phosphatase
-
reactivation by phosphorylase kinase
-
Phosphorylase phosphatase
-
characterization
-
Polyethyleneglycol
-
-
proline
-
concentrations of 0.1 M have a slight accelerating effect on thermal aggregation of glycogen phosphorylase b. The suppression aggregation at high proline concentrations is mainly due to the protective action of proline on the stage of unfolding of the molecule
prop-2-en-1-yl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
propyl (2beta)-2-hydroxyolean-12-en-28-oate
-
-
pterolactone
-
-
pyrazolo[4,3-b]olean-12-en-28-oic acid
-
-
pyridine 3-aldehyde
-
weak inhibition of phosphorylase I, not II
pyridine 4-aldehyde
-
inhibition of phosphorylase I, not II
pyridoxal
-
phosphorylase I, not II
pyridoxal 5'-phosphate
-
74 and 76% inhibition of phosphorylase II and I respectively
pyridoxamine
-
weak inhibition of phosphorylase I, not II
pyridoxamine 5'-phosphate
-
weak inhibition of phosphorylase I, not II
quercetagetin
-
noncompetitive
quercetin
-
50% inhibition of phosphorylated, active enzyme at 0.0048 mM, 50% inhibition of unphosphorylated, adenosine monophosphate-activated enzyme at 0.0209 mM
quercetin
-
inhibits Pa-catalyzed As(V) reduction, inhibition of As(V) reduction is not influenced by glucose or AMP
resorcinol
-
1 mM, 50% inhibition of phosphorylase A and B, 23% inhibition of phosphorylase C
Sn2+
Q9ATK9
-
sodium dodecylsulfate
-
-
Tannic acid
-
0.005 mg, complete inhibition of phosphorylase B, 63% and 50% inhibition of phosphorylase A and C respectively
TDPglucose
-
competitive inhibition
tert-butyl (5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-1-carboxylate 2,2-dioxide
-
-
tert-butyl (5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(naphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-1-carboxylate 2,2-dioxide
-
-
tert-butyl (5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-1-carboxylate 2,2-dioxide
-
-
UDP
-
at high glucose 1-phosphate concentration, glycogen synthesis, not phosphorolysis
UDP-glucose
-
strong inhibition
UDP-glucose
-
-
UDPglucose
Gracilaria sordida
-
-
UDPglucose
-
weak inhibition
UDPglucose
-
kinetics
UDPglucose
-
reversible by Mg2+
UDPglucose
-
competitive to glucose 1-phosphate, non-competitive to phosphate
UDPglucose
-
5 mM, 42% inhibition
UDPglucose
-
strong inhibition; weak inhibition
UDPglucose
-
weak inhibition
UDPglucose
-
kinetics
UDPglucose
-
1 mM, 43, 27 and 18% inhibition of phosphorylases A, B and C respectively
UDPglucose
-
10 mM, 44% inhibition at non-saturating levels of glucose 1-phosphate
UDPglucose
-
2-3 mM, 50% inhibition of phosphorylase II, glucan phosphorolysis
UDPglucose
-
weak inhibition
UDPglucose
-
strong inhibition
vanadate
-
5 mM, more than 50% inhibition of glucan phosphorolysis
Zn2+
-
strong inhibition
Zn2+
-
2 mM, 63% inhibition in the presence of 1 mM AMP
Zn2+
-
strong inhibition
Zn2+
-
4 mM, more than 50% inhibition
Zn2+
-
2 mM, complete inhibition
Zn2+
Voandzeia subterranea
-
1 mM, 27% inhibition
Zn2+
-
0.1 mM, complete inhibition; strong inhibition
Zn2+
Q9ATK9
-
[(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)oxy]acetic acid
-
-
[(alpha-D-glucopyranosyloxy)methyl]phosphonic acid
-
competitive vs. glucose 1-phosphate
[1-(6-[4-[(acetyloxy)methyl]-1H-1,2,3-triazol-1-yl]hexyl)-1H-1,2,3-triazol-4-yl]methyl (3b)-3-hydroxyolean-12-en-28-oate
-
-
[[(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)methyl]sulfanyl]acetic acid
-
-
monohydroxyphenols
-
10 mM, no inhibition at 1 mM
-
additional information
-
not inhibited by glucose
-
additional information
-
not inhibited by Mg2+ and Mn2+
-
additional information
-
not inhibited by AMP
-
additional information
-
not inhibited by 2-mercaptoethanol; not inhibited by Sr2+
-
additional information
-
not inhibited by 3-phosphoglycerate; not inhibited by acetate, acetylphosphate, butyrylphosphate, 6-phosphogluconate; not inhibited by fructose 6-phosphate
-
additional information
-
not inhibited by 1,10-phenanthroline
-
additional information
-
not inhibited by IMP
-
additional information
-
not inhibited by glucose
-
additional information
-
not inhibited by glucose-6-phosphate
-
additional information
-
not inhibited by GMP; not inhibited by TMP; not inhibited by UMP, CMP, CTP
-
additional information
-
not inhibited by maltose, maltotriose, maltotetraose
-
additional information
-
not inhibited by 2-mercaptoethanol; not inhibited by non-aromatic amino acids; not inhibited by p-coumaric acid, caffeic acid or cinnamic acid
-
additional information
-
not inhibited by 3-phosphoglycerate; not inhibited by adenosine, cytosine; not inhibited by F-, ClO4-; not inhibited by fructose 6-phosphate; not inhibited by GMP; not inhibited by non-aromatic amino acids; not inhibited by succinate, 2-oxoglutarate, malate
-
additional information
-
not inhibited by fructose 6-phosphate; not inhibited by GMP; not inhibited by GTP; not inhibited by UMP, CMP, CTP
-
additional information
-
not inhibited by fructose 6-phosphate; not inhibited by fructose, sucrose, dihydroxyacetone phosphate, 6-phosphogluconate, 2-phosphoglycollate, 2-phosphoglycerate, pyruvate
-
additional information
-
not inhibited by fructose 6-phosphate
-
additional information
-
not inhibited by K+, Na+
-
additional information
-
muscle enzyme is not inhibited by beta-amylose
-
additional information
-
not inhibited by 2-mercaptoethanol; not inhibited by agarose; not inhibited by gibberellic acid, indolyl-3-acetic acid; not inhibited by Ni2+
-
additional information
-
-
-
additional information
-
not inhibited by azide
-
additional information
-
not inhibited by aromatic compounds
-
additional information
-
not inhibited by cyclodextrin
-
additional information
-
no or poor inhibition by ribose 5-phosphate, glucose 6-phosphate, fructose-1,6-bisphosphate, ADP and UDP
-
additional information
-
maltohexaose causes negligible substrate inhibition with Ki of 360 mM
-
additional information
-
activity is decreased in hyposmotic media
-
additional information
-
binding and inhibition mechanism, no inhibition by (2,3,6-tri-O-methyl)-gamma-cyclodextrin
-
additional information
-
preference for hydrophobic group at C-28 of maslinic acid for enzyme inhibition
-
additional information
-
pentacyclic triterpenes may exert hypoglycemic effects, at least in part, through glycogen phosphorylase inhibition
-
additional information
-
the more active phosphorylated form of the enzyme, glycogen phosphorylase a, is a homodimer having an inhibitory allosteric binding site at the dimer interface for which synthetic ligands
-
additional information
-
inhibitor screening, native ligand docking of inhibitor tautomers supplemented by QM/MM calculations, modeling of free state ligands and bound ligands, detailed overview
-
additional information
-
inhibitory efficiency and inhibition kinetics of beta-D-glucopyranosyl-thiosemicarbazone derivatives as glycogen phosphorylase inhibitors, binding analysis, overview
-
additional information
-
N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase, synthesis and evaluation by kinetic and crystallographic data, NMR structure analysis, molecular docking and modelling, overview. N-(trifluoroacetyl)-alpha-D-glucopyranosylamine and N-(trifluoroacetyl)-alpha-D-glucopyranosylamine are not inhibitory
-
additional information
-
the purine inhibitory site binds purine derivatives as well as pentacyclic triterpenes. Synthesis and inhibitory potencies of triazole-linked oleanolic acid dimers as enzyme inhibitors, overview. No inhibition by hexane-1,6-diyl(3beta,3'beta)-bis(3-hydroxyolean-12-en-28-oate) and dibenzyl (3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oate
-
additional information
-
evaluation of pentacyclic triterpenes as a class of inhibitors against glycogen phosphorylase, by receptor-based comparative molecular field analysis, and comparative molecular similarity analysis to investigate the quantitative structure-activity relationships of 106 compounds, detailed overview
-
additional information
-
synthesis of glucopyranonucleosides in the 5-alkynyl- and 6-alkylfurano[2,3-d]pyrimidine series, overview
-
additional information
-
synthesis of C-glucosylated spiro-sulfamide enzyme inhibitors via nucleophilic displacement of 1-O-tosyl or 1-deoxy-1-iodo-alpha-D-gluco-hept-2-ulopyranose tetra-O-benzylated derivative using aryl amines, followed by the formation of the corresponding cyclic sulfamide, overview
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
2-mercaptoethanol
-
activation, 5 mM
2-mercaptoethanol
-
slight activation
2-mercaptoethanol
-
slight activation
5'-AMP
-
activation
5'-AMP
-
activation
5'-AMP
-
0.01 mM, 1.0 mM or 2 mM, maximal stimulation of isozymes a, ab or b, respectively; activation
5'-AMP
-
activation; in both directions
5'-AMP
-
activation; slight activation
5'-AMP
-
activation; slight activation
5'-AMP
-
activation; half-maximal activation of isoenzyme b at approx. 0.7 mM, isozyme a is not activated
5'-AMP
-
activation; inhibition of phosphorolysis at 2 mM and above; significant activation by synergism with NaF, glycogen as substrate, inhibition above 2 mM; slight activation
5'-AMP
-
activation; muscle enzyme activator site
5'-AMP
-
activation
5'-AMP
Voandzeia subterranea
-
4 mM, 38 and 51% activation in the presence of 2 and 8 mM glucose 1-phosphate; activation
5'-AMP
Indocibium guttattam
-
activation
5'-AMP
-
activation; half-maximal activation of phosphorylase Ib at 0.022 mM, 0.007 mM for phosphorylase IIb
5'-AMP
-
activation; phosphorylase Ia, half-maximal activity at 0.25 mM, phosphorylase IIIa, half-maximal activity at 6 mM
5'-AMP
-
activation
5'-AMP
-
activation
5'-AMP
-
activation; kidney dephosphorylase is not activated by AMP; required for dephospho-phosphorylase, kinetics
5'-AMP
-
1 mM, 200fold activation of phosphorylase b, completely abolished by caffeine, half-maximal activation of phosphorylases b, ab and a at 0.466, 0.0154 and 0.001 mM AMP respectively
5'-AMP
-
kinetic mechanism of activation
5'-AMP
-
activation of phosphorolysis
ADP
-
activation, in the absence of AMP
ADP-glucose
-
170% activation of glycogen synthesis in the absence of AMP and NaF, 68% inhibition in the presence of AMP and NaF
Albumin
-
activation, reaction without primer glucan
-
AMP
-
physiological activator
AMP
-
quantification of the allosteric effect and the thermodynamic effect of AMP on phosphorylase b, overview
AMP
-
binds at the allosteric site
AMP
-
slight activation
ATP
-
activation; no activation of synthesis
ATP
-
activation; no activation of phosphorylase A or C
ATP
-
stimulation via P2Y receptor signaling, primarily through P2Y2 receptors
cAMP
-
activation; in the absence of AMP, inhibition at 5 mM
cAMP
Voandzeia subterranea
-
activation
CNO-
-
slight activation
cypermethrin
-
cypermethrin intoxication results in significant increase in glycogen phosphorylase a activity. After recovery for 10 days, glycogen and glycogen phosphorylase activites in kidney recover better than activities in muscle
cysteine
-
activation
cysteine
-
activation; slight
dithiothreitol
-
required to maintain activity
DMSO
-
strong activation of enzyme in hepatocytes
DTT
-
slight activation
EDTA
-
5 mM, 46% activation of phosphorylase C, not A or B
EDTA
Voandzeia subterranea
-
1 mM, 114% activation
ethanol
-
strong activation of enzyme in hepatocytes
fumarate
-
activation
glucose 1-phosphate
Q9ATK9
production of a broad spectrum of MOSs (G4-G19) is stimulated both by phosphate and alpha-D-glucose 1-phosphate
glutathione
-
slight stimulation
glutathione
-
slight activation
glycogen targeting subunit of protein phosphatase 1
-
activates
-
imidazole
-
stimulates activity of the mutant up to 5.5fold
IMP
-
activation of isozyme a and ab, not b
IMP
-
0.1 mM, half-maximal activation of phosphorylase ab
indoleacetic acid
-
activation of phosphorolysis
L-cysteine
-
slight activation
Maleic acid
-
activation
Na2SO4
-
activation
Na2SO4
-
500 mM, 40% activation of phosphorylase b in the presence of AMP
p-hydroxymercuribenzoate
-
slight activation, 0.1-1.0 mM
phosphate
-
0.1-0.74 mol covalently bound phosphate per mol subunit; activation; phosphate content correlates with activity
phosphate
-
activation; phosphorylation site: a single Thr-residue in the N-terminal region; yeast and mammalian enzymes are activated by covalent phosphorylation, phosphorylase kinase
phosphate
-
activation; phosphorylation site: a single Thr-residue in the N-terminal region
phosphate
-
activation; converts phosphorylase b into phosphorylase a; in the presence of ATP-Mg
phosphate
-
activation; converts phosphorylase b into phosphorylase a
phosphate
-
activation
phosphate
-
activation
phosphate
Q9ATK9
production of a broad spectrum of MOSs (G4-G19) is stimulated both by phosphate and alpha-D-glucose 1-phosphate
Phosphorylase kinase
-
activation; incorporates 1 mol phosphate per mol subunit
-
Phosphorylase kinase
-
activation; yeast and mammalian enzymes are activated by covalent phosphorylation of a single Thr-residue in the N-terminal region
-
Phosphorylase kinase
-
activation
-
Phosphorylase kinase
-
activation
-
Phosphorylase kinase
-
activation
-
Phosphorylase kinase
-
activation
-
Phosphorylase kinase
-
activation
-
Phosphorylase kinase
-
1000fold increase in activity after phosphorylation
-
protamine
-
stimulation, dephospho-phosphorylase, kinetics
protein kinase A
-
activates the enzyme via phosphorylation, which is induced by dibutyryl cAMP, forskolin, and glucagon
-
pyruvate
Voandzeia subterranea
-
stimulation
sulfate
-
activates the wild-type but not the N-terminally truncated mutant
UTP
-
stimulation via P2Y receptor signaling, primarily through P2Y2 receptors
Mercaptoacetic acid
-
1 mM, activation, inhibition at 5 mM
additional information
-
not activated by 2'-AMP, 3'-AMP, ADP, adenosine; not activated by ATP, cAMP
-
additional information
-
not activated by 5'-AMP
-
additional information
-
not activated by ATP, cAMP; not activated by ATP-regenerating systems
-
additional information
-
not activated by AMP
-
additional information
-
not activated by serine, leucine, isoleucine, methionine, ornithine, L-arginine
-
additional information
-
not activated by indoleacetic acid and gibberellic acid
-
additional information
-
not activated by indoleacetic acid and gibberellic acid
-
additional information
-
activity is increased in hyperosmotic media by 7fold, activation is not influenced by EDTA or 8-bromo-Rp-cAMP
-
additional information
-
Arg-vasopressin and phenylephrine activate the enzyme through the phosphoinositide cascade
-
additional information
-
anoxia (or ischemia) results in the rapid activation of glycogen phosphorylase
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.054
-
alpha-D-glucose 1-phosphate
-
pH 6.8, 50C, synthesis reaction
0.41
-
alpha-D-glucose 1-phosphate
-, Q2VA40, Q2VA41
pH 7.0, 30C
0.68
-
alpha-D-glucose 1-phosphate
-, Q2VA40, Q2VA41
pH 7.0, 30C
0.85
-
alpha-D-glucose 1-phosphate
-
pH 7.0, 30C, recombinant wild-type enzyme, synthesis
1.1
-
alpha-D-glucose 1-phosphate
-
pH 7.0, 30C, recombinant mutant H334Q, synthesis
1.3
-
alpha-D-glucose 1-phosphate
-
pH 7.0, 30C, recombinant mutant H334N, synthesis
1.8
-
alpha-D-glucose 1-phosphate
-
pH 7.0, 30C, recombinant mutant H334A, synthesis
2.1
-
alpha-D-glucose 1-phosphate
-
pH 5.5, 37C, synthesis reaction
0.1
-
alpha-glucan
-
-
0.15
-
alpha-glucan
-
-
0.26
-
alpha-glucan
-
-
0.00003
-
AMP
-
phosphorylase a
0.007
-
AMP
-
phosphorylase ab
0.074
-
AMP
-
phosphorylase b
0.1
-
AMP
-
phosphorylase b
0.125
-
AMP
-
glycogen synthesis, in the presence of NaF
0.25
-
AMP
-
glycogen synthesis
0.27
-
AMP
-
phosphorylase b
1.11
-
AMP
Voandzeia subterranea
-
in the presence of 10 mM glucose 1-phosphate
2.7
-
AMP
Voandzeia subterranea
-
in the presence of 2 mM glucose 1-phosphate
0.0046
-
Amylopectin
-
pH 5.5, 37C, synthesis reaction
0.017
-
Amylopectin
-
stromal phosphorylase, synthesis
0.028
-
Amylopectin
-
stromal phosphorylase, phosphorolysis
0.03
-
Amylopectin
Q9LKJ3
pH 7.5, 30C, degradation reaction, cytosolic isozyme; pH 7.5, 37C, synthesis reaction, cytosolic isozyme
0.71
-
Amylose
Q9LKJ3
pH 7.5, 30C, degradation reaction, cytosolic isozyme
1.1
-
Amylose
-
fast isoenzyme, amylose phosphorolysis
3.01
-
Amylose
Q9LKJ3
pH 7.5, 37C, synthesis reaction, cytosolic isozyme
3.1
-
Amylose
-
slow isoenzyme, amylose phosphorolysis
14.3
-
Amylose
-
slow isoenzyme, amylose synthesis
20
-
Amylose
-
fast isoenzyme, amylose synthesis
22.7
-
arsenate
-
maltohexaose arsenolysis
0.33
-
D-glucose-1-phosphate
-
mutant T706I, 37C, pH 5.5
0.48
-
D-glucose-1-phosphate
-
mutant F39L/N135S/T706I, 37C, pH 5.5
0.56
-
D-glucose-1-phosphate
-
mutant N135S/T706I, 37C, pH 5.5
0.57
-
D-glucose-1-phosphate
-
wild-type, 37C, pH 5.5
0.59
-
D-glucose-1-phosphate
-
mutant N135S, 37C, pH 5.5
0.62
-
D-glucose-1-phosphate
-
mutant F39L/N135S, 37C, pH 5.5
0.76
-
D-glucose-1-phosphate
-
mutant F39L/T706I, 37C, pH 5.5
0.96
-
D-glucose-1-phosphate
-
mutant F39L, 37C, pH 5.5
0.0418
-
Dextrin
-
pH 5.5, 37C, synthesis reaction
0.5
-
dextrin DP11
-
phosphorolysis
-
46.48
-
dextrin DP11
-
synthesis
-
0.73
-
dextrin DP14
-
pH 7.2, 50C, degradation reaction
-
1.2
-
dextrin DP14
-
pH 6.8, 50C, synthesis reaction
-
0.39
-
dextrin DP19
-
pH 7.2, 50C, degradation reaction
-
1.9
-
dextrin DP19
-
pH 6.8, 50C, synthesis reaction
-
1.8
-
dextrin DP4
-
pH 7.2, 50C, degradation reaction
-
17.1
-
dextrin DP4
-
pH 6.8, 50C, synthesis reaction
-
1.22
-
dextrin DP9
-
phosphorolysis
-
0.05
-
glucose 1-phosphate
-
glucan synthesis
0.12
-
glucose 1-phosphate
-
glucan synthesis
0.4
-
glucose 1-phosphate
-
in the presence of Mg2+
0.55
-
glucose 1-phosphate
-
glucan synthesis
0.66
-
glucose 1-phosphate
-
starch synthesis
0.72
-
glucose 1-phosphate
-
chloroplast phosphorylase
0.86
-
glucose 1-phosphate
-
-
0.92
-
glucose 1-phosphate
-
cytoplasmic phosphorylase
0.96
-
glucose 1-phosphate
-
synthesis at pH 7.2
1
-
glucose 1-phosphate
-
-
1
-
glucose 1-phosphate
-
synthesis
1.04
-
glucose 1-phosphate
-
dextrin DP11 synthesis
1.19
-
glucose 1-phosphate
-
at 3.1 mM starch
1.2
-
glucose 1-phosphate
-
-
1.2
-
glucose 1-phosphate
-
synthesis
1.25
-
glucose 1-phosphate
-
at 6.2 mM starch
1.3
-
glucose 1-phosphate
-
-
1.38
-
glucose 1-phosphate
-
at 18.6 mM starch
1.4
-
glucose 1-phosphate
-
starch synthesis, phosphorylase A
1.51
-
glucose 1-phosphate
-
stromal phosphorylase
1.6
-
glucose 1-phosphate
-
-
1.7
-
glucose 1-phosphate
-
phosphorylase a
1.8
-
glucose 1-phosphate
-
-
2.2
-
glucose 1-phosphate
-
maltose synthesis, phosphorylase A
2.7
-
glucose 1-phosphate
-
starch synthesis, phosphorylase C
2.78
-
glucose 1-phosphate
Voandzeia subterranea
-
in the presence of 5 mM AMP
2.9
-
glucose 1-phosphate
-
-
3.3
-
glucose 1-phosphate
-
starch synthesis, phosphorylase B
3.4
-
glucose 1-phosphate
-
glycogen synthesis
3.5
-
glucose 1-phosphate
-
phosphorylase a
3.56
-
glucose 1-phosphate
-
phosphorylase a
4
-
glucose 1-phosphate
-
maltose synthesis, phosphorylase C
4
-
glucose 1-phosphate
-
phosphorylase I
5
-
glucose 1-phosphate
-
glycogen synthesis, phosphorylase A
5.5
-
glucose 1-phosphate
-
phosphorylase II
5.5
-
glucose 1-phosphate
-
phosphorylase b
6
-
glucose 1-phosphate
-
heart phosphorylase I and III
7.14
-
glucose 1-phosphate
Voandzeia subterranea
-
in the presence of 0.5 mM AMP
8.3
-
glucose 1-phosphate
-
-
15
-
glucose 1-phosphate
-
phosphorylase b, pH 6.3
16
-
glucose 1-phosphate
-
-
18
-
glucose 1-phosphate
-
phosphorylase ab
20
-
glucose 1-phosphate
-
phosphorylase ab
22
-
glucose 1-phosphate
-
phosphorylase b, pH 6.8
1
-
Glucose-1-phosphate
-
-
2.2
-
Glucose-1-phosphate
-
-
3.4
-
Glucose-1-phosphate
-
glycogen synthesis
0.0138
-
glycogen
-
pH 5.5, 37C, synthesis reaction
0.04
-
glycogen
Q9LKJ3
pH 7.5, 30C, degradation reaction, cytosolic isozyme
0.07
-
glycogen
Q9LKJ3
pH 7.5, 37C, synthesis reaction, cytosolic isozyme
0.1
-
glycogen
-
phosphorylase b
0.1
-
glycogen
-
phosphorolysis
0.15
-
glycogen
-
phosphorolysis
0.25
-
glycogen
-
stromal phosphorylase, synthesis
0.43
-
glycogen
-
phosphorylase a
0.5
-
glycogen
-
phosphorylase a and ab
0.55
-
glycogen
-
phosphorylase ab
0.62
-
glycogen
-
synthesis
0.67
-
glycogen
-
synthesis
0.94
-
glycogen
-
stromal phosphorylase, phosphorolysis
1.3
-
glycogen
-
fast isoenzyme, glycogen phosphorolysis
1.4
-
glycogen
-
kidney phosphophosphorylase
1.6
-
glycogen
-
pH 7.0, 30C, recombinant wild-type enzyme and mutant H334A, phosphorolysis
1.7
-
glycogen
-
pH 7.0, 30C, recombinant mutant H334Q, phosphorolysis
6.04
-
glycogen
-
phosphorylase b
6.5
-
glycogen
-
slow isoenzyme, glycogen phosphorolysis
16
-
glycogen
-
pH 7.0, 30C, recombinant mutant H334N, phosphorolysis
22.2
-
glycogen
-
slow isoenzyme, glycogen synthesis
40
-
glycogen
-
fast isoenzyme, glycogen synthesis
0.27
-
glycogen DP14
-
phosphorolysis
-
4.32
-
glycogen DP14
-
synthesis
-
0.49
-
KF
-
glycogen synthesis
0.21
-
maltodecaheptaose
-
phosphorolysis
0.5
-
maltodecaheptaose
-
synthesis
0.08
-
maltoheptaose
-
stromal phosphorylase, synthesis
0.1
-
maltoheptaose
-
stromal phosphorylase, phosphorolysis
0.12
-
maltoheptaose
-
synthesis, isoenzyme P-2
0.18
-
maltoheptaose
-
synthesis, isoenzyme P-2
0.19
-
maltoheptaose
O66932
pH 6.5, 37C, recombinant enzyme, phosphorolysis reaction
0.2
-
maltoheptaose
-
phosphorolysis
0.26
-
maltoheptaose
-
synthesis, isoenzyme P-1
0.38
-
maltoheptaose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
0.59
-
maltoheptaose
-
synthesis, isoenzyme P-1
0.81
-
maltoheptaose
Q9LKJ3
pH 7.5, 30C, degradation reaction, cytosolic isozyme
1.1
-
maltoheptaose
-
synthesis, isoenzyme P-1
1.22
-
maltoheptaose
-
phosphorolysis
1.7
-
maltoheptaose
-
phosphorolysis, at 30C
2.2
-
maltoheptaose
-
synthesis
3.6
-
maltoheptaose
-
phosphorolysis, at 70C
3.72
-
maltoheptaose
-
phosphorolysis
4.49
-
maltoheptaose
Q9LKJ3
pH 7.5, 37C, synthesis reaction, cytosolic isozyme
5.9
-
maltoheptaose
-
phosphorolysis
7.1
-
maltoheptaose
-
phosphorolysis
31
-
maltoheptaose
-
synthesis
33
-
maltoheptaose
-
synthesis
39.86
-
maltoheptaose
-
synthesis
0.16
-
maltohexaose
-
stromal phosphorylase, synthesis
0.18
-
maltohexaose
O66932
pH 6.5, 37C, recombinant enzyme, phosphorolysis reaction
0.21
-
maltohexaose
-
stromal phosphorylase, phosphorolysis
0.3
-
maltohexaose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
0.68
-
maltohexaose
-
phosphorolysis
2.5
-
maltohexaose
-
synthesis
2.65
-
maltohexaose
-
recombinant wild-type enzyme
3.15
-
maltohexaose
-
phosphorolysis
7.1
-
maltohexaose
-
phosphorolysis
8.3
-
maltohexaose
-
phosphorolysis
27
-
maltohexaose
-
synthesis
32
-
maltohexaose
-
synthesis
0.72
-
maltooctaose
-
phosphorolysis
2
8.3
maltooctaose
-
maltoheptaose, maltohexaose, maltopentaose, maltotetraose, synthesis
2
-
maltooctaose
-
synthesis
0.11
-
maltopentaose
-
-
0.17
-
maltopentaose
O66932
pH 6.5, 37C, recombinant enzyme, phosphorolysis reaction
0.23
-
maltopentaose
-
stromal phosphorylase, phosphorolysis
0.27
-
maltopentaose
-
stromal phosphorylase, synthesis
0.28
-
maltopentaose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
0.49
-
maltopentaose
-
synthesis, isoenzyme P-2
0.93
-
maltopentaose
-
phosphorolysis
1.7
-
maltopentaose
-
synthesis, isoenzyme P-1
2.73
-
maltopentaose
-
phosphorolysis
3
-
maltopentaose
-
synthesis
3.5
-
maltopentaose
-
pH 7.0, 30C, recombinant mutant H334A, phosphorolysis
3.8
-
maltopentaose
-
pH 7.0, 30C, recombinant wild-type enzyme, phosphorolysis
4.1
-
maltopentaose
-
pH 7.0, 30C, recombinant mutant H334Q, phosphorolysis
8.8
-
maltopentaose
-
; phosphorolysis
9.1
-
maltopentaose
-
; phosphorolysis
38
-
maltopentaose
-
synthesis
42
-
maltopentaose
-
synthesis
103
-
maltopentaose
-
pH 7.0, 30C, recombinant mutant H334N, phosphorolysis
280
-
maltopentaose
-
pH 7.0
1.44
-
maltose
-
pH 6.2, 37C, synthetic direction, wild-type enzyme
0.28
-
maltotetraose
-
pH 6.2, 37C, phosphorolytic direction, wild-type enzyme
0.3
-
maltotetraose
O66932
pH 6.5, 37C, recombinant enzyme, phosphorolysis reaction
0.44
-
maltotetraose
Q9LKJ3
pH 7.5, 37C, synthesis reaction, cytosolic isozyme
0.478
-
maltotetraose
-
pH 6.2, 37C, synthetic direction, wild-type enzyme
0.55
-
maltotetraose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
0.57
-
maltotetraose
-
stromal phosphorylase, synthesis
1.54
-
maltotetraose
-
mutant F39L/T706I, 37C, pH 5.5
1.87
-
maltotetraose
-
mutant T706I, 37C, pH 5.5
1.96
-
maltotetraose
-
mutant N135S, 37C, pH 5.5
2
-
maltotetraose
-
mutant F39L, 37C, pH 5.5; mutant F39L/N135S, 37C, pH 5.5
2.11
-
maltotetraose
-
wild-type, 37C, pH 5.5
2.47
-
maltotetraose
-
mutant N135S/T706I, 37C, pH 5.5
2.57
-
maltotetraose
-
mutant F39L/N135S/T706I, 37C, pH 5.5
2.8
-
maltotetraose
-
phosphorolysis, at 30C
3.6
-
maltotetraose
-
synthesis
3.9
-
maltotetraose
-
phosphorolysis
4.8
-
maltotetraose
-
phosphorolysis, at 70C
8.3
-
maltotetraose
-
synthesis
12.7
-
maltotetraose
-
synthesis
44
-
maltotetraose
-
synthesis
53
-
maltotetraose
-
synthesis
0.3
-
maltotriose
-
pH 6.2, 37C, synthetic direction, mutant enzyme k308A
0.31
-
maltotriose
-
pH 6.2, 37C, synthetic direction, wild-type enzyme
0.35
-
maltotriose
-
pH 6.2, 37C, synthetic direction, mutant enzyme R303A
0.69
-
maltotriose
-
pH 6.2, 37C, synthetic direction, mutant enzyme H185A
0.79
-
maltotriose
-
pH 6.2, 37C, phosphorolytic direction, wild-type enzyme
0.88
-
maltotriose
-
synthesis, isoenzyme P-2
1.8
-
maltotriose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
13.4
-
maltotriose
-
synthesis
24.5
-
maltotriose
-
synthesis
0.45
-
phosphate
-
phosphorolysis at pH 7.2
0.5
-
phosphate
-
phosphorolysis
0.9
-
phosphate
-
cytoplasmic phosphorylase, pH 7.0
1.15
-
phosphate
-
phosphorylase a
1.18
-
phosphate
-
dextrin DP9 phosphorolysis
1.2
-
phosphate
-
isoenzyme A
1.2
-
phosphate
-
chloroplast phosphorylase, pH 7.0
1.5
-
phosphate
-
-
1.5
-
phosphate
-
isoenzyme b, in the presence of 3 mM 5'-AMP
1.5
-
phosphate
-
cytoplasmic phosphorylase, pH 8.0
1.5
-
phosphate
-
phosphorylase II
1.6
-
phosphate
-, Q2VA40, Q2VA41
pH 7.0, 30C
1.8
-
phosphate
-
chloroplastphosphorylase, pH 8.0
1.9
-
phosphate
-
phosphorylase I
1.9
-
phosphate
-
phosphorolysis, at 30C
1.9
-
phosphate
-, Q2VA40, Q2VA41
pH 7.0, 30C
2.01
-
phosphate
-
phosphorylase a
2.2
-
phosphate
-
phosphorolysis of glucan
2.2
-
phosphate
-
phosphorolysis, at 70C
2.26
-
phosphate
-
stromal phosphorylase
2.3
-
phosphate
-
kidney phosphophosphorylase, in the presence of 0.8 mg glycogen
2.4
-
phosphate
-
glucan phosphorolysis
2.6
-
phosphate
-
phosphorylase ab
2.6
-
phosphate
-
kidney phosphophosphorylase, in the presence of 0.4 mg glycogen
2.8
-
phosphate
-
kidney phosphophosphorylase, in the presence of 0.2 mg glycogen
2.9
-
phosphate
-
kidney phosphophosphorylase, in the presence of 0.1 mg glycogen
3.03
-
phosphate
-
phosphorylase ab
3.2
-
phosphate
-
-
4
-
phosphate
-
70C, pH 7.0
4.1
-
phosphate
-
chloroplast phosphorylase
5.3
-
phosphate
-
cytoplasmic phosphorylase
6
-
phosphate
-
recombinant wild-type enzyme
6.8
-
phosphate
-
pH 7.0, 30C, recombinant wild-type enzyme, phosphorolysis
7.7
-
phosphate
-
pH 7.2, 50C, degradation reaction
10.87
-
phosphate
-
starch phosphorolysis
11
-
phosphate
-
phosphorylase b
12
-
phosphate
-
pH 7.0, 30C, recombinant mutants H334A and H334Q, phosphorolysis
13
-
phosphate
-
pH 7.0, 30C, recombinant mutant H334N, phosphorolysis
17.89
-
phosphate
-
phosphorylase b
20
-
phosphate
-
isozyme ab; phosphorylase b
20
-
phosphate
-
phosphorolysis of oyster glycogen
20
-
phosphate
-
glycogen, dephospho-phosphorylase
25
-
phosphate
-
phosphorolysis of corn dextrin
28
-
phosphate
-
phosphorylase ab
30
-
phosphate
-
kidney dephosphophosphorylase, in the presence of 1.6 mg glycogen
31
-
phosphate
Q8U0Q0
80C, pH 6.5; pH 6.8, 80C
55
-
phosphate
-
isoenzyme b, in the absence of 5'-AMP
70
-
phosphate
-
kidney dephosphophosphorylase, in the presence of 0.8 mg glycogen
100
-
phosphate
-
dephospho-phosphorylase; kidney dephosphophosphorylase, in the presence of 0.2 mg glycogen
0.0106
-
soluble starch
-
pH 5.5, 37C, synthesis reaction
-
0.0261
-
soluble starch
-
pH 5.5, 37C, synthesis reaction
-
0.1
-
soluble starch
Q9LKJ3
pH 7.5, 37C, synthesis reaction, cytosolic isozyme
-
0.15
-
soluble starch
Q9LKJ3
pH 7.5, 30C, degradation reaction, cytosolic isozyme
-
0.013
-
starch
-
pH 6.2, 37C, phosphorolytic direction, wild-type enzyme
0.04
-
starch
-
phosphorolysis
0.045
-
starch
-
pH 6.2, 37C, synthetic direction, wild-type enzyme
0.23
-
starch
-
pH 7.0, 30C, recombinant wild-type enzyme, phosphorolysis
0.25
-
starch
-
pH 7.0, 30C, recombinant mutant H334A, phosphorolysis
0.3
-
starch
-
pH 7.2, 50C, degradation reaction
0.32
-
starch
-
pH 7.0, 30C, recombinant mutant H334Q, phosphorolysis
0.5
-
starch
-
fast isoenzyme, starch phosphorolysis
0.8
-
starch
-
slow isoenzyme, starch phosphorolysis
1
-
starch
-
pH 7.0, 30C, recombinant mutant H334N, phosphorolysis
1.5
-
starch
-
pH 6.8, 50C, synthesis reaction
4.4
-
starch
-
at 0.5 mM glucose 1-phosphate
5.6
-
starch
-
at 1.0 mM glucose 1-phosphate
6.7
-
starch
-
slow isoenzyme, starch synthesis
8
-
starch
-
fast isoenzyme, starch synthesis
15.5
-
starch
-
at 5 mM glucose 1-phosphate
0.47
-
starch DP24
-
synthesis
-
70
-
maltotriose
Q8U0Q0
80C, pH 6.5, direction of glucose 1-phosphate synthesis; pH 6.8, 80C
additional information
-
additional information
-
kinetic data
-
additional information
-
additional information
Gracilaria sordida
-
0.264 mg/ml, amylopectin, 0.277 mg/ml, glycogen, 0.285 mg/ml, amylose, 0.453 mg/ml, maltodextrin
-
additional information
-
additional information
-
kinetic mechanism
-
additional information
-
additional information
-
0.46% glycogen, with AMP, 0.67% glycogen, without AMP
-
additional information
-
additional information
-
20 mg/ml, oyster glycogen, phosphorolysis, 25 mg/ml, endogen glycogen, synthesis, 27 mg/ml, corn dextrin, phosphorolysis, 40 mg/ml, corn dextrin, synthesis; 42 mg/ml, oyster glycogen, synthesis
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
1.26 mg/ml, glycogen; kinetic data
-
additional information
-
additional information
-
0.36 mg/ml, glycogen
-
additional information
-
additional information
-
5 mg/ml, oyster glycogen
-
additional information
-
additional information
-
0.65 mg/ml, glycogen
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
2.7 mg/ml, glycogen, isozyme a; 4.2 mg/ml, glycogen, isozyme b
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
kinetic data
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
amylopectin, 0.69 mg/ml and 0.68 mg/ml for phosphorolysis and synthesis, respectively; kinetic data
-
additional information
-
additional information
-
-
-
additional information
-
additional information
-
0.24 mg/ml starch, phosphorylase A; 1.1 mg/ml, glycogen, phosphorylase A; 1.21 mg/ml, starch, phosphorylase C; kinetic parameters of 3 starch phosphorylases
-
additional information
-
additional information
-
0.13 mg/ml, starch phosphorolysis; 0.19 mg/ml, starch synthesis
-
additional information
-
additional information
Voandzeia subterranea
-
kinetic data
-
additional information
-
additional information
-
kinetic data
-
additional information
-
additional information
-
kinetic data
-
additional information
-
additional information
-
kinetic data
-
additional information
-
additional information
-
kinetic data
-
additional information
-
additional information
Indocibium guttattam
-
kinetic data
-
additional information
-
additional information
-
comparison of muscle phosphorylases of various animals; kinetic data
-
additional information
-
additional information
-
comparison of muscle phosphorylases of various animals; kinetic data
-
additional information
-
additional information
-
kinetic data
-
additional information
-
additional information
-
kinetic data
-
additional information
-
additional information
-
kinetic data
-
additional information
-
additional information
-
12 mg/ml maltodextrin
-
additional information
-
additional information
-
1.3 mg/ml, maltodextrin
-
additional information
-
additional information
-
0.13 mg/ml amylopectin, 0.45 mg/ml glycogen
-
additional information
-
additional information
-
stopped-flow and steady-state kinetics, wild-type and mutant enzymes
-
additional information
-
additional information
O66932
kinetics, forward and reverse reaction, recombinant enzyme
-
additional information
-
additional information
-
allosteric kinetics, overview
-
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.68
-
alpha-D-glucose 1-phosphate
-
pH 7.0, 30C, recombinant mutant H334Q, synthesis
1.27
-
alpha-D-glucose 1-phosphate
-
pH 7.0, 30C, recombinant mutant H334N, synthesis
4.2
-
alpha-D-glucose 1-phosphate
-
pH 6.8, 50C, synthesis reaction
49
-
alpha-D-glucose 1-phosphate
-
pH 7.0, 30C, recombinant mutant H334A, synthesis
52
-
alpha-D-glucose 1-phosphate
-
pH 7.0, 30C, recombinant wild-type enzyme, synthesis
0.00048
-
alpha-D-xylose 1-phosphate
-
pH 7.0, 30C, recombinant mutant H334N, synthesis
0.0026
-
alpha-D-xylose 1-phosphate
-
pH 7.0, 30C, recombinant wild-type enzyme, synthesis
0.0028
-
alpha-D-xylose 1-phosphate
-
pH 7.0, 30C, recombinant mutant H334A, synthesis
0.0066
-
alpha-D-xylose 1-phosphate
-
pH 7.0, 30C, recombinant mutant H334Q, synthesis
4.9
-
arsenate
-
maltohexaose arsenolysis
0.001
-
D-glucose-1-phosphate
-
wild-type, 37C, pH 5.5
0.0019
-
D-glucose-1-phosphate
-
mutant N135S, 37C, pH 5.5
0.0023
-
D-glucose-1-phosphate
-
mutant F39L, 37C, pH 5.5
0.0026
-
D-glucose-1-phosphate
-
mutant T706I, 37C, pH 5.5
0.0036
-
D-glucose-1-phosphate
-
mutant F39L/N135S/T706I, 37C, pH 5.5
0.0041
-
D-glucose-1-phosphate
-
mutant N135S/T706I, 37C, pH 5.5
0.0042
-
D-glucose-1-phosphate
-
mutant F39L/N135S, 37C, pH 5.5
0.0049
-
D-glucose-1-phosphate
-
mutant F39L/T706I, 37C, pH 5.5
50
-
dextrin DP11
-
phosphorolysis
-
187
-
dextrin DP11
-
synthesis
-
3.6
-
dextrin DP14
-
pH 6.8, 50C, synthesis reaction
-
9.3
-
dextrin DP14
-
pH 7.2, 50C, degradation reaction
-
6.6
-
dextrin DP19
-
pH 6.8, 50C, synthesis reaction
-
8.1
-
dextrin DP19
-
pH 7.2, 50C, degradation reaction
-
8.4
-
dextrin DP4
-
pH 7.2, 50C, degradation reaction
-
11
-
dextrin DP4
-
pH 6.8, 50C, synthesis reaction
-
47.3
-
dextrin DP9
-
phosphorolysis
-
131
-
glucose 1-phosphate
-
dextrin DP11 synthesis
34.5
-
glycogen DP14
-
phosphorolysis
-
283
-
glycogen DP14
-
synthesis
-
2.3
-
maltoheptaose
O66932
pH 6.5, 37C, recombinant enzyme, phosphorolysis reaction
4.4
-
maltoheptaose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
41.3
-
maltoheptaose
-
phosphorolysis
312
-
maltoheptaose
-
synthesis
2.7
-
maltohexaose
O66932
pH 6.5, 37C, recombinant enzyme, phosphorolysis reaction
4.1
-
maltohexaose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
38.9
-
maltohexaose
-
phosphorolysis
0.033
-
maltopentaose
-
pH 7.0
2.2
-
maltopentaose
O66932
pH 6.5, 37C, recombinant enzyme, phosphorolysis reaction
5.4
-
maltopentaose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
33.8
-
maltopentaose
-
phosphorolysis
15.2
-
maltose
-
pH 6.2, 37C, synthetic direction, wild-type enzyme
0.0017
-
maltotetraose
-
mutant F39L, 37C, pH 5.5
0.002
-
maltotetraose
-
mutant N135S, 37C, pH 5.5
0.0027
-
maltotetraose
-
mutant F39L/T706I, 37C, pH 5.5
0.0029
-
maltotetraose
-
mutant T706I, 37C, pH 5.5
0.0036
-
maltotetraose
-
mutant F39L/N135S, 37C, pH 5.5
0.0037
-
maltotetraose
-
mutant F39L/N135S/T706I, 37C, pH 5.5; wild-type, 37C, pH 5.5
0.0044
-
maltotetraose
-
mutant N135S/T706I, 37C, pH 5.5
0.16
-
maltotetraose
-
pH 6.2, 37C, phosphorolytic direction, wild-type enzyme
0.76
-
maltotetraose
O66932
pH 6.5, 37C, recombinant enzyme, phosphorolysis reaction
6
-
maltotetraose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
34.6
-
maltotetraose
-
pH 6.2, 37C, synthetic direction, wild-type enzyme
0.06
-
maltotriose
-
pH 6.2, 37C, phosphorolytic direction, wild-type enzyme
0.11
-
maltotriose
-
pH 6.2, 37C, synthetic direction, mutant enzyme k308A
0.16
-
maltotriose
-
pH 6.2, 37C, synthetic direction, mutant enzyme R303A
0.73
-
maltotriose
-
pH 6.2, 37C, synthetic direction, mutant enzyme H185A
6.8
-
maltotriose
O66932
pH 6.5, 37C, recombinant enzyme, synthesis reaction
24.8
-
maltotriose
-
pH 6.2, 37C, synthetic direction, wild-type enzyme
2.1
-
phosphate
-
70C, pH 7.0
8.2
-
phosphate
-
pH 7.2, 50C, degradation reaction
40
-
phosphate
-
30C, pH 7.0, mutant R141A
44
-
phosphate
-
30C, pH 7.0, mutant K31A; 30C, pH 7.0, mutant S174A; 30C, pH 7.0, mutant T28A
47
-
phosphate
-
30C, pH 7.0, wild-type
50.5
-
phosphate
-
dextrin DP9 phosphorolysis
0.2
-
starch
-
pH 6.2, 37C, phosphorolytic direction, wild-type enzyme
0.52
-
starch
-
pH 7.0, 30C, recombinant mutant H334Q, phosphorolysis
1.5
-
starch
-
pH 7.0, 30C, recombinant mutant H334N, phosphorolysis
2.1
-
starch
-
pH 6.8, 50C, synthesis reaction
6.3
-
starch
-
pH 7.2, 50C, degradation reaction
19.4
-
starch
-
pH 6.2, 37C, synthetic direction, wild-type enzyme
69.9
-
starch
-
phosphorolysis
74
-
starch
-
pH 7.0, 30C, recombinant wild-type enzyme, phosphorolysis
80
-
starch
-
pH 7.0, 30C, recombinant mutant H334A, phosphorolysis
300
-
starch DP24
-
synthesis
-
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
7.7
-
alpha-D-glucose 1-phosphate
-
pH 6.8, 50C, synthesis reaction
6756
3
-
dextrin DP14
-
pH 6.8, 50C, synthesis reaction
0
13
-
dextrin DP14
-
pH 7.2, 50C, degradation reaction
0
3.5
-
dextrin DP19
-
pH 6.8, 50C, synthesis reaction
0
21
-
dextrin DP19
-
pH 7.2, 50C, degradation reaction
0
0.64
-
dextrin DP4
-
pH 6.8, 50C, synthesis reaction
0
4.7
-
dextrin DP4
-
pH 7.2, 50C, degradation reaction
0
1.1
-
phosphate
-
pH 7.2, 50C, degradation reaction
27500
1.5
-
starch
-
pH 6.8, 50C, synthesis reaction
16701
21
-
starch
-
pH 7.2, 50C, degradation reaction
16701
Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.00016
-
(1S)-1,5-anhydro-D-glucitol-spiro[1.5]-3-(2-naphthyl)-1,4,2-oxathiazole
-
-
0.0082
-
(1S)-1,5-anhydro-D-glucitol-spiro[1.5]-3-(4-methoxyphenyl)-1,4,2-oxathiazole
-
-
0.0393
-
(2R,3R,4S,5R,6R)-3,4,5,9-tetrahydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione
-
-
0.0031
-
(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-1-oxa-spiro[4,5]decane-8,10-dione
-
pH 6.8, 30C
0.00063
-
(5R,7R,8R,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene-8,9,10-triol
P00489
pH 6.8
0.0066
-
(5R,7R,8R,9S,10R)-7-(hydroxymethyl)-3-(4-methoxyphenyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene-8,9,10-triol
P00489
pH 6.8
0.0079
-
(5R,7R,8R,9S,10R)-7-(hydroxymethyl)-3-(4-toluyl)-1,6-dioxa-2-azaspiro[4,5]dec-2-ene-8,9,10-triol
P00489
pH 6.8
0.32
-
(5R,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione
-
pH and temperature not specified in the publication
0.015
-
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
pH and temperature not specified in the publication
0.0051
-
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one
-
pH and temperature not specified in the publication
0.0031
-
(5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione
-
pH and temperature not specified in the publication
0.48
-
1,3,5-tris-4'-2''-[3'''-C-(beta-D-glucopyranosyl)-1''',2''',4'''-oxadiazol-5'''-yl]ethyl-1',2',3'-triazol-1'-ylmethylbenzene
-
-
0.535
-
1,3,5-tris[3'-C-(beta-D-glucopyranosyl)-1',2',4'-oxadiazol-5'-yl]-benzene
-
-
3.204
-
1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)uracil
-
pH 6.8, 30C
0.303
-
1-(beta-D-glucopyranosyl)-5-(pent-1-yn-1-yl)uracil
-
pH 6.8, 30C
0.0047
-
1-(beta-D-glucopyranosyl)-5-ethynyluracil
-
pH 6.8, 30C
0.001
-
1-(beta-D-glucopyranosyl)-5-iodouracil
-
pH 6.8, 30C
0.086
-
1-deoxy-1-methoxycarbonylamino-beta-D-glucopyranose
-
-
0.0334
-
3-(beta-D-glucopyranosyl)-6-pentyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one
-
pH 6.8, 30C
0.0324
-
3-(beta-D-glucopyranosyl)-6-propyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one
-
pH 6.8, 30C
0.0015
-
4-S-alpha-D-glucopyranosyl-4-thiomaltotetraose
-
-
0.0116
-
5-(beta-D-glucopyranosyl)-3-(2-naphthyl)-1,2,4-oxadiazole
-
-
0.0088
-
5-(beta-D-glucopyranosyl)-3-(4-methylphenyl)-1,2,4-oxadiazole
-
-
0.02
-
ADP-glucose
-
-
0.2
-
ADP-glucose
-, Q2VA40, Q2VA41
presence of 1 mM orthophosphate, pH 7.0, 30C
0.7
-
ADP-glucose
-
-
1
-
ADP-glucose
-, Q2VA40, Q2VA41
presence of 1 mM orthophosphate, pH 7.0, 30C
0.033
-
ADPglucose
-
synthesis
0.11
-
ADPglucose
-
phosphorolysis
47.1
-
alpha-cyclodextrin
-
with respect to glycogen
3.5
-
alpha-cyclodextrin dialdehyde
-
-
-
0.07
-
alpha-D-Glucopyranose-1,2-cyclic phosphate
-
-
0.44
-
alpha-D-glucopyranosyl fluoride
-
phosphorylase b, at 1 mM vs. glucose 1-phosphate
0.71
-
alpha-D-glucopyranosyl fluoride
-
phosphorylase b, at 1 mM vs. phosphate
14
-
alpha-D-glucopyranosyl fluoride
-
at 10 mM vs. glucose 1-phosphate
18
-
alpha-D-glucopyranosyl fluoride
-
at 10 mM vs. phosphate
1.7
-
alpha-D-glucose
-
pH 6.8, 30C
0.1
-
alpha-D-glucose-1-methylenephosphonate
-
-
0.4
-
alpha-D-glucose-1-methylenephosphonate
-
-
0.5
-
arsenate
-
-
4.1
-
arsenate
-
-
0.0013
-
beta-amylase
-
-
-
14.1
-
beta-cyclodextrin
-
with respect to glycogen
1.9
-
beta-cyclodextrin dialdehyde
-
-
-
1
-
beta-D-glucopyranosyl 1-(2-cyclopropylamino-2-oxoacetyl)-amide
-
-
0.92
-
beta-D-glucopyranosyl 1-(ethoxy(oxo)acetyl)-amide
-
-
0.21
-
beta-D-glucopyranosyl 1-(methoxy(oxo)acetyl)-amide
-
-
0.71
-
beta-D-glucopyranosyl 1-oxalylamide
-
-
5.9
-
beta-D-glucopyranosyl bismethoxyphosphoramidate
-
pH 6.8, 30C, versus alpha-D-glucose 1-phosphate, synthesis reaction
0.00046
-
FR258900
-
-
3.3
-
fructose 1,6-diphosphate
-
-
5.2
-
fructose 6-phosphate
-
-
7.4
-
gamma-cyclodextrin
-
with respect to glycogen
11.2
-
gamma-cyclodextrin dialdehyde
-
-
0.02
-
GDP-glucose
-
-
0.03
-
GDP-glucose
-
-
0.9
-
gluconolactone
-
-
3.3
-
gluconolactone
-
-
0.0031
-
glucopyranosylidene spirohydantoin
-
-
0.0023
-
glucopyranosylidene spirothiohydantoin
-
muscle phosphorylase b, vs. phosphate
0.0028
-
glucopyranosylidene spirothiohydantoin
-
muscle phosphorylase b, vs. glycogen
2.5
-
glucose
-
-
4.5
-
glucose
-
phosphorylase ab and a
0.1
-
glucose 1-phosphate
-
-
0.1
-
glucose 1-phosphate
-
-
5.09
-
glucose 1-phosphate
-
at pH 7.2
0.29
-
glucose 6-phosphate
-
unphosphorylated glycogen phosphorylase
1.5
-
glucose 6-phosphate
-
phosphorylase ab
4.8
-
glucose 6-phosphate
-
phosphorylated glycogen phosphorylase
0.02
-
N-(3-carboxypropanoyl)-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.37
-
N-(acetylcarbamoyl)-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.049
-
N-(azidoacetyl)-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.0046
-
N-(benzoylcarbamoyl)-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
5.9
-
N-(dimethoxyphosphoryl)-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.01
-
N-(naphthalen-2-ylcarbonyl)-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.075
-
N-(trifluoroacetyl)-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.15
-
N-([4-[(benzyloxy)carbonyl]benzoyl]carbamoyl)-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.032
-
N-acetyl-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.14
-
N-carbamoyl-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.081
-
N-phenyl-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.006
-
N-[(4-aminobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.085
-
N-[(4-carboxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.0044
-
N-[(4-chlorobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.0063
-
N-[(4-hydroxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.0032
-
N-[(4-methoxybenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.0023
-
N-[(4-methylbenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.0033
-
N-[(4-nitrobenzoyl)carbamoyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.0037
-
N-[(biphenyl-4-ylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.21
-
N-[methoxy(oxo)acetyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.004
-
N-[[4-(methoxycarbonyl)benzoyl]carbamoyl]-beta-D-glucopyranosylamine
-
pH and temperature not specified in the publication
0.02
-
NaHSO3
-
competitive. vs. arsenate in arsenolysis of starch
1.7
-
NaHSO3
-
-
0.69
-
phosphate
Q9ATK9
Pho1 with amylopectin as primer in the reaction, pH 6.5, 22C
4.36
-
phosphate
-
at pH 7.2
14.2
-
phosphate
Q9ATK9
Pho1 with short alpha-glucan chain as primer in the reaction, pH 6.5, 22C
0.0035
-
quercetagetin
-
pH 6.8, 25C
1
-
TDP-glucose
-
-
0.06
-
UDP-glucose
-
-
2
-
UDP-glucose
-
-
0.15
-
UDPglucose
-
synthesis
0.51
-
UDPglucose
-
phosphorolysis
0.67
-
UDPglucose
-
-
0.92
-
UDPglucose
-
-
IC50 VALUE [mM]
IC50 VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.000018
-
(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
pH and temperature not specified in the publication
0.0015
-
(2-[[(2,3-dichloro-4H-thieno[3,2-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
pH and temperature not specified in the publication
0.00004
-
(2-[[(2-chloro-6H-thieno[2,3-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
pH and temperature not specified in the publication
0.0012
-
(2-[[(2-chloro-6H-thieno[2,3-b]pyrrol-5-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
pH and temperature not specified in the publication
0.000057
-
(2-[[(5-chloro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
pH and temperature not specified in the publication
0.00026
-
(2-[[(5-chloro-1H-pyrrolo[2,3-c]pyridin-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
pH and temperature not specified in the publication
0.000076
-
(2-[[(5-chloro-6-fluoro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
pH and temperature not specified in the publication
0.000052
-
(2-[[(5-chloro-7-fluoro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
pH and temperature not specified in the publication
0.00016
-
(2-[[(5-fluoro-1H-indol-2-yl)carbonyl]amino]-2,3-dihydro-1H-inden-1-yl)acetic acid
-
pH and temperature not specified in the publication
0.0161
-
(2alpha)-3-hydroxyolean-12-en-28-oic acid
-
pH 7.2, 22C
0.0133
-
(2alpha,3beta)-2,3-bis(acetyloxy)olean-12-en-28-oic acid
-
pH 7.2, 22C
0.0252
-
(2alpha,3beta)-2,3-bis(butanoyloxy)olean-12-en-28-oic acid
-
pH 7.2, 22C
0.0105
-
(2alpha,3beta)-2,3-bis(propanoyloxy)olean-12-en-28-oic acid
-
pH 7.2, 22C
0.0206
-
(2beta)-2-hydroxyurs-12-en-28-oic acid
-
pH 7.2, 22C
0.0227
-
(2beta)-3-hydroxyolean-12-en-28-oic acid
-
pH 7.2, 22C
0.00625
-
(2beta,3alpha)-2,3-dihydroxyolean-12-en-28-oic acid
-
pH 7.2, 22C
0.0011
-
(2beta,3alpha)-2,3-dihydroxyurs-12-en-28-oic acid
-
pH 7.2, 22C
0.000026
-
(2E,2'E)-N,N'-(oxydiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide]
-
pH 6.8, 22C, presence of glucose
0.00043
-
(2E,2'E)-N,N'-(oxydiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide]
-
pH 6.8, 22C
0.000012
-
(2E,2'E)-N,N'-(thiodiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide]
-
pH 6.8, 22C, presence of glucose
0.00045
-
(2E,2'E)-N,N'-(thiodiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide]
-
pH 6.8, 22C
0.000043
-
(2E,2'E)-N,N'-butane-1,4-diylbis[3-(3,4-dichlorophenyl)-acrylamide]
-
pH 6.8, 22C, presence of glucose
0.00042
-
(2E,2'E)-N,N'-butane-1,4-diylbis[3-(3,4-dichlorophenyl)-acrylamide]
-
pH 6.8, 22C
0.000023
-
(2E,2'E)-N,N'-pentane-1,5-diylbis[3-(3,4-dichlorophenyl)acrylamide]
-
pH 6.8, 22C, presence of glucose
0.00026
-
(2E,2'E)-N,N'-pentane-1,5-diylbis[3-(3,4-dichlorophenyl)acrylamide]
-
pH 6.8, 22C
0.00001
-
(2R)-2-cyclohexyl-2-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]propanoic acid
-
-
0.000009
-
(2S)-2-[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]heptanoic acid
-
-
0.000006
-
(2S)-cyclohexyl[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]ethanoic acid
-
-
0.000014
-
(2S)-cyclopentyl[[(3-[[(2,4,6-trimethylphenyl)carbamoyl]amino]naphthalen-2-yl)carbonyl]amino]ethanoic acid
-
-
0.0131
-
(2Z)-2-(hydroxyimino)olean-12-en-28-oic acid
-
pH 7.2, 22C
0.0147
-
(2Z)-2-(hydroxyimino)urs-12-en-28-oic acid
-
pH 7.2, 22C
0.00325
-
(3beta)-28-[(2-[[2-(acetylamino)ethyl]amino]ethyl)amino]-28-oxoolean-12-en-3-yl acetate
-
pH 7.2, 22C
0.0152
-
(3beta)-28-[(3-aminopropyl)amino]-28-oxolup-20(29)-ene-3,23-diyl diacetate
-
-
0.0035
-
(3beta)-28-[(6-aminohexyl)amino]-28-oxolup-20(29)-ene-3,23-diyl diacetate
-
-
0.0309
-
(3beta)-3-[[(4-[[(phenylacetyl)oxy]methyl]-1H-1,2,3-triazol-1-yl)acetyl]oxy]olean-12-en-28-oic acid
-
pH 7.2, 22C
0.0102
-
(3beta)-N-(6-aminohexyl)-3,23-dihydroxylup-20(29)-en-28-amide
-
-
0.0031
-
(3beta,12alpha,13xi)-3,12-dihydroxyoleanan-28-oic acid
-
pH 7.2, 22C
0.00259
-
(3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oic acid
-
pH 7.2, 22C
0.0026
-
(3beta,3'beta)-3,3'-[hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy)]bisolean-12-en-28-oic acid
-
pH 7.2, 22C
0.0251
-
(4aS,6aS,6bR,8aR,14aR,14bR,16bS)-2,2,6a,6b,9,9,14a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-hexadecahydrochryseno[1,2-g]quinoxaline-4a(2H)-carboxylic acid
-
pH 7.2, 22C
0.014
-
(6aS,6bR,8aR,16aR,16bR,18bS)-2,2,6a,6b,9,9,16a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,16,16a,16b,17,18b-hexadecahydrochryseno[1,2-b]phenazine-4a(2H)-carboxylic acid
-
pH 7.2, 22C
0.0493
-
1'-(methylsulfonyl)pyrazolo[4,3-b]olean-12-en-28-oic acid
-
pH 7.2, 22C
-
0.0538
-
1'-acetylpyrazolo[4,3-b]