Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | allosteric activator | Oryctolagus cuniculus |
Crystallization (Comment) | Organism |
---|---|
determination of crystal structures of the glycogen phosphorylase b-gallic acid and glycogen phosphorylase b-ellagic acid complexes, overview | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Caffeine | - |
Oryctolagus cuniculus | |
chrysin | - |
Oryctolagus cuniculus | |
ellagic acid | competitive inhibitor with respect to the substrate, glucose-1-phoshate, and non-competitive to the allosteric activator, AMP. Ellagic acid functions with glucose in a strongly synergistic mode. Determination of crystal structures of the GPb-gallic acid and GPb-ellagic acid complexes, overview | Oryctolagus cuniculus | |
flavopiridol | - |
Oryctolagus cuniculus | |
gallic acid | competitive inhibitor with respect to the substrate, glucose-1-phoshate, and non-competitive to the allosteric activator, AMP | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[(1->4)-alpha-D-glucosyl]n + phosphate | Oryctolagus cuniculus | - |
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | P00489 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | glycogen phosphorylase a is prepared from glycogen phosphorylase b by phosphorylation through a truncated form of the catalytic subunit of rabbit skeletal muscle phosphorylase kinase | Oryctolagus cuniculus |
Purification (Comment) | Organism |
---|---|
native glycogen phosphorylase b from skeletal muscle, glycogen phosphorylase a is prepared from glycogen phosphorylase b by phosphorylation | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[(1->4)-alpha-D-glucosyl]n + phosphate | - |
Oryctolagus cuniculus | [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
glycogen phosphorylase b | - |
Oryctolagus cuniculus |
GPA | - |
Oryctolagus cuniculus |
GPb | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at, glycogen synthesis | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at, glycogen synthesis | Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.73 | - |
ellagic acid | pH 6.8, 30°C | Oryctolagus cuniculus | |
13.4 | - |
gallic acid | pH 6.8, 30°C | Oryctolagus cuniculus |