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Literature summary for 2.4.1.1 extracted from

  • Tite, T.; Tomas, L.; Docsa, T.; Gergely, P.; Kovensky, J.; Gueyrard, D.; Wadouachi, A.
    Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors (2012), Tetrahedron Lett., 53, 959-961.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
(5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane 2,2-dioxide
-
Oryctolagus cuniculus
(5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(naphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane 2,2-dioxide
-
Oryctolagus cuniculus
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
Oryctolagus cuniculus
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
Oryctolagus cuniculus
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(naphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide
-
Oryctolagus cuniculus
1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-methylidene-D-glucitol
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-(hydroxymethyl)-alpha-D-glucopyranose
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-(iodomethyl)-alpha-D-glucopyranose
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-({[(4-methylphenyl)sulfonyl]oxy}methyl)-alpha-D-glucopyranose
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-({[2-(1H-indol-3-yl)ethyl]amino}methyl)-alpha-D-glucopyranose
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-methyl-alpha-D-glucopyranose
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-[(chlorooxy)methyl]-alpha-D-glucopyranose
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-[(hydroxyamino)methyl]-alpha-D-glucopyranose
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-[(naphthalen-2-ylamino)methyl]-alpha-D-glucopyranose
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-[(pyridin-2-ylamino)methyl]-alpha-D-glucopyranose
-
Oryctolagus cuniculus
2,3,4,6-tetra-O-benzyl-1-C-{[(4-methoxyphenyl)amino]methyl}-alpha-D-glucopyranose
-
Oryctolagus cuniculus
additional information synthesis of C-glucosylated spiro-sulfamide enzyme inhibitors via nucleophilic displacement of 1-O-tosyl or 1-deoxy-1-iodo-alpha-D-gluco-hept-2-ulopyranose tetra-O-benzylated derivative using aryl amines, followed by the formation of the corresponding cyclic sulfamide, overview Oryctolagus cuniculus
tert-butyl (5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-1-carboxylate 2,2-dioxide
-
Oryctolagus cuniculus
tert-butyl (5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-3-(naphthalen-2-yl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-1-carboxylate 2,2-dioxide
-
Oryctolagus cuniculus
tert-butyl (5S,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-[(benzyloxy)methyl]-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-1-carboxylate 2,2-dioxide
-
Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Synonyms

Synonyms Comment Organism
glycogen phosphorylase
-
Oryctolagus cuniculus
glycogen phosphorylase b
-
Oryctolagus cuniculus
rmGPb
-
Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.015
-
(5S,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methoxyphenyl)-6-oxa-2-thia-1,3-diazaspiro[4.5]decane-8,9,10-triol 2,2-dioxide pH and temperature not specified in the publication Oryctolagus cuniculus