3.4.22.28: picornain 3C

This is an abbreviated version!
For detailed information about picornain 3C, go to the full flat file.

Reaction

Selective cleavage of Gln-/-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly =

Synonyms

3C protease, 3C protein, 3C proteinase, 3C-like protease, 3C-protease, 3CL, 3cLpro, 3CP, 3Cpro, 3Cpro protease, Avihepatovirus 3C protease, coxsackievirus 3C proteinase, cysteine proteinase 3C, DHAV 3C protease, enterovirus 3C protease, EV71 3Cpro, foot-and-mouth protease 3C, HAC 3C, HAV 3C protease, HAV 3Cpro, hepatitis A virus 3C proteinase, HRV 3C protease, HRV 3Cpro, HRV type-14 3C protease, HRV16 3C protease, Human rhinovirus 3C protease, human rhinovirus type-14 3C protease, nonstructural 3 protease, NS3 protease, NS6 protease, P3C, picornain 3C, picornain-3C, picornaviral 3C protease, picornavirus endopeptidase 3C, poliovirus protease 3C, poliovirus proteinase 3C, protease 3C, proteinase, foot-and-mouth-disease virus, 3C, proteinase, picornavirus, 3C, proteinase, poliovirus, 3C, proteinase, rhinovirus, 3C, rhinovirus 3C protease, rhinovirus protease 3C, SAT-type 3C protease, Senecavirus A 3C protease, SV3CP, SVA 3Cpro, tomato ringspot nepovirus 3C-related protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.28 picornain 3C

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Results	in table
7	Activating Compound
6497	AA Sequence
22	Application
1	CAS Registry Number
80	Cloned(Commentary)
1	Cofactor
22	Crystallization (Commentary)
35	General Information
4	General Stability
154	IC50 Value
492	Inhibitors
18	kcat/KM [mM/s]
24	Ki Value [mM]
40	KM Value [mM]
38	Localization
6	Metals/Ions
19	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
182	Organism
450	PDB ID
27	pH Optimum
5	pI Value
1	Posttranslational Modification
120	Protein Variants
54	Purification (Commentary)
1	Reaction
10	Reaction Type
162	Reference
14	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
343	Substrates and Products (Substrate)
8	Subunits
207	Synonyms
25	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
36	Turnover Number [1/s]

Synonyms

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Synonyms on EC 3.4.22.28 - picornain 3C

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3C protease

38 entries

3C protein

2 entries

3C proteinase

8 entries

3C-like protease

4 entries

3C-protease

rhinovirus A16

-

-

753189

3CL

Ectropis obliqua virus

-

-

732970

3cLpro

Human rhinovirus sp.

-

-

732410

3CP

6 entries

3Cpro

29 entries

3Cpro protease

Coxsackievirus B3

-

-

718305

Avihepatovirus 3C protease

Avihepatovirus A

YP_007969882

-

755644

coxsackievirus 3C proteinase

-

-

-

-

cysteine proteinase 3C

-

-

-

-

DHAV 3C protease

Avihepatovirus A

YP_007969882

-

755644

enterovirus 3C protease

4 entries

EV71 3Cpro

Enterovirus A71

-

-

752985

foot-and-mouth protease 3C

-

-

-

-

HAC 3C

-

-

-

-

HAV 3C protease

Hepatovirus A

-

-

753494

HAV 3Cpro

Hepatovirus A

-

-

753494

hepatitis A virus 3C proteinase

-

-

-

-

HRV 3C protease

3 entries

HRV 3Cpro

Human rhinovirus sp.

-

-

753494

HRV type-14 3C protease

Rhinovirus B14

-

-

754696

HRV16 3C protease

rhinovirus A16

Q82122

-

755496

Human rhinovirus 3C protease

2 entries

human rhinovirus type-14 3C protease

Rhinovirus B14

-

-

754696

nonstructural 3 protease

Hepacivirus C

-

-

681224

NS3 protease

Hepacivirus C

-

-

681224

NS6 protease

Norwalk virus

-

-

731277

P3C

-

-

-

-

picornain 3C

3 entries

picornain-3C

Enterovirus C

-

-

678152

picornaviral 3C protease

2 entries

picornavirus endopeptidase 3C

-

-

-

-

poliovirus protease 3C

-

-

-

-

poliovirus proteinase 3C

-

-

-

-

protease 3C

3 entries

proteinase, foot-and-mouth-disease virus, 3C

-

-

-

-

proteinase, picornavirus, 3C

-

-

-

-

proteinase, poliovirus, 3C

-

-

-

-

proteinase, rhinovirus, 3C

-

-

-

-

rhinovirus 3C protease

rhinovirus A16

-

-

753189

rhinovirus protease 3C

-

-

-

-

SAT-type 3C protease

Foot-and-mouth disease virus SAT 2

Q1EF85

-

754997

Senecavirus A 3C protease

Senecavirus A

-

-

753660

SV3CP

Southampton virus

Q04544

-

717256

SVA 3Cpro

Senecavirus A

-

-

753660

tomato ringspot nepovirus 3C-related protease

-

-

-

-

3C protease

-

-

-

-

3C protease

Avihepatovirus A

YP_007969882

-

755644

3C protease

Bovine alphaherpesvirus 1

-

-

707300

3C protease

Bovine alphaherpesvirus 1 Schoenboeken

-

-

-

3C protease

coxsackievirus

-

-

701391

3C protease

Coxsackievirus A16

-

-

718053

3C protease

Coxsackievirus A21

-

-

754557

3C protease

Coxsackievirus B3

-

-

677619, 677969, 754557, 755655

3C protease

Coxsackievirus B3 Nancy

-

-

-

3C protease

enterovirus

-

-

667222, 669536, 696733

3C protease

Enterovirus A71

-

-

677544, 710399, 718053, 732244, 732416, 752985, 754320, 754557

3C protease

Enterovirus A71

E7E815

-

731147

3C protease

Enterovirus A71

E9LTP4

-

718052

3C protease

Enterovirus B93

-

-

718054

3C protease

Enterovirus C

-

-

670077, 670238, 701391

3C protease

enterovirus CVB2

-

-

-

3C protease

Enterovirus D68

-

-

732420, 754557

3C protease

Enterovirus D68 3799

-

-

-

3C protease

Foot-and-mouth disease virus

-

-

667051, 669311, 669682, 680186, 681679, 681699, 707300, 709535, 731458, 732414, 755650

3C protease

Foot-and-mouth disease virus A Iran 97

-

-

-

3C protease

Foot-and-mouth disease virus A1061

-

-

-

3C protease

Foot-and-mouth disease virus A10_61

-

-

-

3C protease

Foot-and-mouth disease virus O/NY00

-

-

-

3C protease

Foot-and-mouth disease virus SAT 1

Q1EFA8, Q91CA5

-

754997

3C protease

Foot-and-mouth disease virus SAT 2

Q1EF85, Q719N0

-

754997

3C protease

Hepacivirus C

-

-

681224

3C protease

Hepatovirus A

-

-

669869, 681388, 732422

3C protease

Human poliovirus 1

-

-

732410

3C protease

Human poliovirus 1 Mahoney

-

-

-

3C protease

Human poliovirus 3

-

-

717313

3C protease

Human rhinovirus sp.

-

-

667222, 669609, 669683, 678237, 679407, 707670, 709744, 731121, 732410, 752996

3C protease

Norwalk virus

-

-

717352, 731277

3C protease

picornaviridae

-

-

698873

3C protease

rhinovirus A16

-

-

754550

3C protease

rhinovirus A2

-

-

717361

3C protease

Rhinovirus B14

-

-

718360, 753010, 754696

3C protease

Southampton virus

Q04544

-

717256

3C protease

tobacco etch virus

-

-

731121

3C protein

Enterovirus A71

-

-

709754

3C protein

picornaviridae

-

-

701364

3C proteinase

-

-

-

-

3C proteinase

coxsackievirus

-

-

670906

3C proteinase

coxsackievirus CVB3

-

-

-

3C proteinase

Encephalomyocarditis virus

-

-

732409

3C proteinase

Enterovirus A71

A9XG43

-

731063

3C proteinase

Enterovirus A71 E2004104-TW-CDC

A9XG43

-

-

3C proteinase

Enterovirus C

-

-

699905, 701390

3C proteinase

Hepatovirus A

-

-

668861, 696722

3C-like protease

Coxsackievirus B3

-

-

717370

3C-like protease

Ectropis obliqua virus

-

-

732970

3C-like protease

Human rhinovirus sp.

-

-

732410

3C-like protease

Severe acute respiratory syndrome-related coronavirus

-

-

717370

3CP

Bovine alphaherpesvirus 1

-

-

707300

3CP

Bovine alphaherpesvirus 1 Schoenboeken

-

-

-

3CP

Coxsackievirus B3

-

-

677969

3CP

Foot-and-mouth disease virus

-

-

707300, 709535

3CP

Foot-and-mouth disease virus A Iran 97

-

-

-

3CP

Human rhinovirus sp.

-

-

696711

3Cpro

Avihepatovirus A

YP_007969882

-

755644

3Cpro

coxsackievirus

-

-

670906, 701391

3Cpro

Coxsackievirus A21

-

-

754557

3Cpro

Coxsackievirus B3

-

-

677619, 754557

3Cpro

coxsackievirus CVB3

-

-

-

3Cpro

enterovirus

-

-

669536

3Cpro

Enterovirus A71

-

-

710399, 752985, 754320, 754557

3Cpro

Enterovirus A71

A9XG43

-

731063

3Cpro

Enterovirus A71

E9LTP4

-

718052

3Cpro

Enterovirus A71 E2004104-TW-CDC

A9XG43

-

-

3Cpro

Enterovirus B93

-

-

718054

3Cpro

Enterovirus C

-

-

670077, 670238, 699905, 701390, 701391

3Cpro

Enterovirus D68

-

-

732420, 754557

3Cpro

Enterovirus D68 3799

-

-

-

3Cpro

Foot-and-mouth disease virus

-

-

667051, 669311, 669682, 731458, 732414

3Cpro

Foot-and-mouth disease virus

-

3Cpro from foot-and-mouth disease is unusual among 3C proteases in being able to cleave sequences with P1-Gln or P1-Glu

680186

3Cpro

Foot-and-mouth disease virus

-

a chymotrypsin-like cysteine protease

681679

3Cpro

Foot-and-mouth disease virus A1061

-

a chymotrypsin-like cysteine protease

-

3Cpro

Foot-and-mouth disease virus A10_61

-

-

-

3Cpro

Foot-and-mouth disease virus SAT 1

Q1EFA8, Q91CA5

-

754997

3Cpro

Foot-and-mouth disease virus SAT 2

Q1EF85, Q719N0

-

754997

3Cpro

Hepatovirus A

-

-

696722, 732422

3Cpro

Human poliovirus 1

-

-

732410

3Cpro

Human poliovirus 1 Mahoney

-

-

-

3Cpro

Human rhinovirus sp.

-

-

669683, 679407, 707670, 732410

3Cpro

Norwalk virus

-

-

717352

3Cpro

rhinovirus A16

-

-

753189, 754550

3Cpro

rhinovirus A2

-

-

717361

3Cpro

Rhinovirus B14

-

-

718360

enterovirus 3C protease

Coxsackievirus A21

-

-

754557

enterovirus 3C protease

Coxsackievirus B3

-

-

754557

enterovirus 3C protease

Enterovirus A71

-

-

754557

enterovirus 3C protease

Enterovirus D68

-

-

754557

HRV 3C protease

Human rhinovirus sp.

-

-

753494, 755121

HRV 3C protease

rhinovirus A16

-

-

754550

HRV 3C protease

Rhinovirus B14

-

-

754696

Human rhinovirus 3C protease

Human rhinovirus sp.

-

-

755121

Human rhinovirus 3C protease

rhinovirus A16

Q82122

-

755496

picornain 3C

coxsackievirus

-

-

701391

picornain 3C

Enterovirus C

-

-

701391

picornain 3C

picornaviridae

-

-

701364

picornaviral 3C protease

Avihepatovirus A

YP_007969882

-

755644

picornaviral 3C protease

Human rhinovirus sp.

-

-

753494

protease 3C

-

-

-

-

protease 3C

coxsackievirus

-

-

670790

protease 3C

Human rhinovirus sp.

-

-

696711