3.4.22.28: picornain 3C

This is an abbreviated version!
For detailed information about picornain 3C, go to the full flat file.

Reaction

Selective cleavage of Gln-/-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly =

Synonyms

3C protease, 3C protein, 3C proteinase, 3C-like protease, 3C-protease, 3CL, 3cLpro, 3CP, 3Cpro, 3Cpro protease, Avihepatovirus 3C protease, coxsackievirus 3C proteinase, cysteine proteinase 3C, DHAV 3C protease, enterovirus 3C protease, EV71 3Cpro, foot-and-mouth protease 3C, HAC 3C, HAV 3C protease, HAV 3Cpro, hepatitis A virus 3C proteinase, HRV 3C protease, HRV 3Cpro, HRV type-14 3C protease, HRV16 3C protease, Human rhinovirus 3C protease, human rhinovirus type-14 3C protease, nonstructural 3 protease, NS3 protease, NS6 protease, P3C, picornain 3C, picornain-3C, picornaviral 3C protease, picornavirus endopeptidase 3C, poliovirus protease 3C, poliovirus proteinase 3C, protease 3C, proteinase, foot-and-mouth-disease virus, 3C, proteinase, picornavirus, 3C, proteinase, poliovirus, 3C, proteinase, rhinovirus, 3C, rhinovirus 3C protease, rhinovirus protease 3C, SAT-type 3C protease, Senecavirus A 3C protease, SV3CP, SVA 3Cpro, tomato ringspot nepovirus 3C-related protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.28 picornain 3C

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Results	in table
7	Activating Compound
6497	AA Sequence
22	Application
1	CAS Registry Number
80	Cloned(Commentary)
1	Cofactor
22	Crystallization (Commentary)
35	General Information
4	General Stability
154	IC50 Value
492	Inhibitors
18	kcat/KM [mM/s]
24	Ki Value [mM]
40	KM Value [mM]
38	Localization
6	Metals/Ions
19	Molecular Weight [Da]
61	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
182	Organism
450	PDB ID
27	pH Optimum
5	pI Value
1	Posttranslational Modification
120	Protein Variants
54	Purification (Commentary)
1	Reaction
10	Reaction Type
162	Reference
14	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
343	Substrates and Products (Substrate)
8	Subunits
207	Synonyms
25	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
36	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.4.22.28 - picornain 3C

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

acetate

Enterovirus C

-

activates

678152

D2O

Enterovirus C

-

-

678152

Sodium citrate

Enterovirus C

-

the peptidase activity of picornain-3C is 100fold higher in the presence of 1.5 M sodium citrate

678152

additional information

4 entries

-

additional information

Coxsackievirus B3

-

polyamines facilitate viral protease activity

755655

-

additional information

Enterovirus C

-

no activation by Triton X-100

647997

-

additional information

Enterovirus C

-

proteinase-active polypeptide precursor (3CD) and mature 3Cpro have equivalent cleavage activity on purified poly(A) binding protein, but only 3Cpro cleavage activity is stimulated by poly(A) binding protein-binding viral RNA

701390

-

additional information

rhinovirus A16

Q82122

the accessibility of the HRV 3C cleavage site within RIPK1 in-vitro is probably increased by concurrent cleavage of RIPK1 through caspase-8

755496

-