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3.4.22.28: picornain 3C

This is an abbreviated version!
For detailed information about picornain 3C, go to the full flat file.

Word Map on EC 3.4.22.28

Reaction

Selective cleavage of Gln-/-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly =

Synonyms

3C protease, 3C protein, 3C proteinase, 3C-like protease, 3C-protease, 3CL, 3cLpro, 3CP, 3Cpro, 3Cpro protease, Avihepatovirus 3C protease, coxsackievirus 3C proteinase, cysteine proteinase 3C, DHAV 3C protease, enterovirus 3C protease, EV71 3Cpro, foot-and-mouth protease 3C, HAC 3C, HAV 3C protease, HAV 3Cpro, hepatitis A virus 3C proteinase, HRV 3C protease, HRV 3Cpro, HRV type-14 3C protease, HRV16 3C protease, Human rhinovirus 3C protease, human rhinovirus type-14 3C protease, nonstructural 3 protease, NS3 protease, NS6 protease, P3C, picornain 3C, picornain-3C, picornaviral 3C protease, picornavirus endopeptidase 3C, poliovirus protease 3C, poliovirus proteinase 3C, protease 3C, proteinase, foot-and-mouth-disease virus, 3C, proteinase, picornavirus, 3C, proteinase, poliovirus, 3C, proteinase, rhinovirus, 3C, rhinovirus 3C protease, rhinovirus protease 3C, SAT-type 3C protease, Senecavirus A 3C protease, SV3CP, SVA 3Cpro, tomato ringspot nepovirus 3C-related protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.28 picornain 3C

Turnover Number

Turnover Number on EC 3.4.22.28 - picornain 3C

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0085
(2-(N-methylamino)benzoyl)-IEALFQGPPK(2,4-dinitrophenyl)-FR
in 50 mM Tris, pH 7.0, at 30°C
0.00025
(E)-5-chloropyridin-3-yl 3-(furan-2-yl)acrylate
-
-
0.0005
2-(N-methylamino)benzoyl-DEAMEQGVSDYIK-2,4-dinitrophenyl
in 50 mM Tris, pH 7.0, at 30°C
0.0027
2-(N-methylamino)benzoyl-IAALFQGPPK(2,4-dinitrophenyl)FR
in 50 mM Tris, pH 7.0, at 30°C
0.005
2-(N-methylamino)benzoyl-IEAAFQGPPK(2,4-dinitrophenyl)FR
in 50 mM Tris, pH 7.0, at 30°C
0.004
2-(N-methylamino)benzoyl-IELLFQGPPK(2,4-dinitrophenyl)FR
in 50 mM Tris, pH 7.0, at 30°C
0.003
2-(N-methylamino)benzoyl-RQAVTQGFPTELK-2,4-dinitrophenyl
in 50 mM Tris, pH 7.0, at 30°C
0.0035
2-(N-methylamino)benzoyl-RTATVQGPSLDFK-2,4-dinitrophenyl
in 50 mM Tris, pH 7.0, at 30°C
0.0003
2-(N-methylamino)benzoyl-TSAVLQSGFRK-(2,4-dinitrophenyl)-Met
in 50 mM Tris, pH 7.0, at 30°C
0.01 - 0.96
2-aminobenzoyl-AALFQGPLQ-EDDnp
0.08 - 3.34
2-aminobenzoyl-EAAFQGPLQ-EDDnp
0.01 - 0.66
2-aminobenzoyl-EALAQGPLQ-EDDnp
0.34
2-aminobenzoyl-EALFQAPLQ-EDDnp
-
in 50 mM Tris-HCl, at pH 8.0, in the presence of 1 M sodium citrate
0.28
2-aminobenzoyl-EALFQGALQ-EDDnp
-
in 50 mM Tris-HCl, at pH 8.0, in the presence of 1 M sodium citrate
0.03 - 2.72
2-aminobenzoyl-EALFQGPAQ-EDDnp
0.03 - 2.02
2-aminobenzoyl-EALFQGPLQ-EDDnp
27
4-(4-dimethylaminophenylazo)benzoic acid-KTSAVLQSGFRKME-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
-
0.00119
5-bromopyridin-3-yl furan-3-carboxylate
-
-
0.0011
5-chloropyridin-3-yl furan-2-carboxylate
-
-
0.33
Ac-DEFQLQ-4-nitroanilide
pH 8.5, temperature not specified in the publication
0.14
Ac-EFQLQ-4-nitroanilide
pH 8.5, temperature not specified in the publication
0.08
Ac-FQLQ-4-nitroanilide
pH 8.5, temperature not specified in the publication
0.0028
Dabcyl-IEALFQGPPKFRE-Edans
in 50 mM Tris, pH 7.0, at 30°C
0.002
Dabcyl-RTATVQGPSLDFKE-Edans
in 50 mM Tris, pH 7.0, at 30°C
0.08
N-acetyl-DEFQLQ-4-nitroanilide
-
pH and temperature not specified in the publication
0.41 - 2.38
SLEVLFQGPVRR
0.036 - 0.22
TENLYFQSGTRR