Application | Comment | Organism |
---|---|---|
drug development | 3CP is an optimal target for the development of anti-viral agents | Human rhinovirus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(benzylamino)-5-[1-N-hydroxyethanimidoyl]benzamide | - |
Human rhinovirus sp. | |
3-(bromoacetyl)-5-(naphth-2-ylmethyl)benzamide | 12% inhibition at inhibitor concentration of 100 nM, 39% inhibition at inhibitor concentration of 1 microM, 83% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
3-(bromoacetyl)benzamide | 4% inhibition at inhibitor concentration of 100 nM, 23% inhibition at inhibitor concentration of 1 microM, 85% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
3-(chloroacetyl)-5-(naphth-2-ylmethyl)benzamide | 25% inhibition at inhibitor concentration of 100 nM, 61% inhibition at inhibitor concentration of 1 microM, 81% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
3-(chloroacetyl)benzamide | - |
Human rhinovirus sp. | |
3-(dibromoacetyl)-5-(naphth-2-ylmethyl)benzamide | - |
Human rhinovirus sp. | |
3-(dibromoacetyl)benzamide | - |
Human rhinovirus sp. | |
3-(dichloroacetyl)benzamide | - |
Human rhinovirus sp. | |
3-(difluoroacetyl)-5-[(phenylcarbonyl)amino]benzamide | - |
Human rhinovirus sp. | |
3-(difluoroacetyl)benzamide | - |
Human rhinovirus sp. | |
3-(trifluoroacetyl)benzamide | no inhibition of 3CP | Human rhinovirus sp. | |
3-(trifluoroacetyl)benzonitrile | - |
Human rhinovirus sp. | |
3-acetyl-5-(5,8-dihydronaphthalen-2-ylmethyl)benzamide | - |
Human rhinovirus sp. | |
3-acetyl-5-(naphth-1-ylcarbamoyl)benzoic acid | - |
Human rhinovirus sp. | |
3-acetyl-5-(phenylcarbamoyl)benzoic acid | - |
Human rhinovirus sp. | |
3-acetyl-5-benzylbenzamide | - |
Human rhinovirus sp. | |
3-acetylbenzamide | - |
Human rhinovirus sp. | |
3-benzyl-5-(bromoacetyl)benzamide | 0% inhibition at inhibitor concentration of 100 nM, 30% inhibition at inhibitor concentration of 1 microM, 68% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
3-benzyl-5-(chloroacetyl)benzamide | 14% inhibition at inhibitor concentration of 100 nM, 79% inhibition at inhibitor concentration of 1 microM, 91% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
3-benzyl-5-(dibromoacetyl)benzamide | 14% inhibition at inhibitor concentration of 100 nM, 27% inhibition at inhibitor concentration of 1 microM, 75% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
3-benzyl-5-(difluoroacetyl)benzamide | - |
Human rhinovirus sp. | |
4-(bromoacetyl)isoindolin-1-one | - |
Human rhinovirus sp. | |
4-acetylisoindolin-1-one | - |
Human rhinovirus sp. | |
4-bromoisoindolin-1-one | - |
Human rhinovirus sp. | |
5-(bromoacetyl)-N-2-naphthylisophthalamide | 5% inhibition at inhibitor concentration of 100 nM, 19% inhibition at inhibitor concentration of 1 microM, 80% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
5-(bromoacetyl)-N-phenylisophthalamide | 8% inhibition at inhibitor concentration of 100 nM, 27% inhibition at inhibitor concentration of 1 microM, 86% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
5-(dibromoacetyl)-N-2-naphthylisophthalamide | - |
Human rhinovirus sp. | |
5-(dibromoacetyl)-N-phenylisophthalamide | - |
Human rhinovirus sp. | |
5-acetyl-N-(naphthalen-1-yl)benzene-1,3-dicarboxamide | - |
Human rhinovirus sp. | |
5-acetyl-N-phenylbenzene-1,3-dicarboxamide | - |
Human rhinovirus sp. | |
6-(bromoacetyl)isoindolyn-1-one | 0% inhibition at inhibitor concentration of 100 nM, 25% inhibition at inhibitor concentration of 1 microM, 70% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
6-acetylisoindolin1-one | - |
Human rhinovirus sp. | |
6-bromoisoindolin-1-one | - |
Human rhinovirus sp. | |
AG7088 | inhibits all 48 serotypes of rhinoviruses | Human rhinovirus sp. | |
AL21-01 | Agouron aldehydic compound, 8% inhibition at inhibitor concentration of 100 nM, 75% inhibition at inhibitor concentration of 1 microM, 92% inhibition at inhibitor concentration of 0.01 mM, 700 nM enzyme | Human rhinovirus sp. | |
dimethyl 5-acetylbenzene-1,3-dicarboxylate | - |
Human rhinovirus sp. | |
ethyl 3-amino-5-[1-(hydroxyamino)ethyl]benzoate | - |
Human rhinovirus sp. | |
methyl 3-benzamido-5-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]ethenyl}benzoate | - |
Human rhinovirus sp. | |
methyl 3-benzyl-5-bromobenzoate | - |
Human rhinovirus sp. | |
methyl 3-bromo-5-(5,8-dihydronaphthalen-2-ylmethyl)benzoate | - |
Human rhinovirus sp. | |
methyl 3-bromo-5-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]ethenyl}benzoate | - |
Human rhinovirus sp. | |
methyl-3-(benzylamino)-5-carbamoylbenzoate | - |
Human rhinovirus sp. | |
methyl-3-amino-5-carbamoylbenzoate | - |
Human rhinovirus sp. | |
methyl-3-carbamoyl-5-(dibenzylamino)benzoate | - |
Human rhinovirus sp. | |
methyl-3-{2,2-difluoro-1-[(2-methoxyethoxy)methoxy]ethenyl}-5-{[(trifluoromethyl)sulfonyl]oxy}benzoate | - |
Human rhinovirus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Thr-Gly-Leu-Phe-Gln-Gly-Pro + H2O | Human rhinovirus sp. | - |
Thr-Gly-Leu-Phe-Gln + Gly-Pro | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human rhinovirus sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Glu-Ala-Leu-Phe-Gln-4-nitroanilide + H2O | - |
Human rhinovirus sp. | Glu-Ala-Leu-Phe-Gln + 4-nitroaniline | - |
? | |
Thr-Gly-Leu-Phe-Gln-Gly-Pro + H2O | - |
Human rhinovirus sp. | Thr-Gly-Leu-Phe-Gln + Gly-Pro | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3CP | - |
Human rhinovirus sp. |
protease 3C | - |
Human rhinovirus sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Human rhinovirus sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Human rhinovirus sp. |