Reference on EC 3.4.22.28 - picornain 3C
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kräusslich, H.G.; Wimmer, E.
Viral proteinases
Annu. Rev. Biochem.
57
701-754
1988
Enterovirus E, coxsackievirus, echovirus, Encephalomyocarditis virus, enterovirus, Foot-and-mouth disease virus, Hepatovirus A, picornaviridae, Enterovirus C
Ivanoff, L.A.; Towatari, T.; Ray, J.; Korant, B.D.; Petteway, S.R.
Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli
Proc. Natl. Acad. Sci. USA
83
5392-5396
1986
Enterovirus C
Gorbalenya, A.E.; Blinov, V.M.; Donchenko, A.P.
Poliovirus-encoded proteinase 3C: a possible evolutionary link between cellular serine and cysteine proteinase families [published erratum appears in FEBS Lett 1986 May 26;201(1):179]
FEBS Lett.
194
253-257
1986
Enterovirus C
Ypma-Wong, M.F.; Semler, B.L.
In vitro molecular genetics as a tool for determining the differential cleavage specificities of the poliovirus 3C proteinase
Nucleic Acids Res.
15
2069-2088
1987
Enterovirus C, Enterovirus C Mahoney
Bazan, J.F.; Fletterick, R.J.
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications
Proc. Natl. Acad. Sci. USA
85
7872-7876
1988
Enterovirus C, Enterovirus C Sabin
Nicklin, M.J.H.; Harris, K.S.; Pallai, P.V.; Wimmer, E.
Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro
J. Virol.
62
4586-4593
1988
Enterovirus C, Enterovirus C Mahoney
Knott, J.A.; Orr, D.C.; Montgomery, D.S.; Sullivan, C.A.; Weston, A.
The expression and purification of human rhinovirus protease 3C
Eur. J. Biochem.
182
547-555
1989
enterovirus
Hämmerle, T.; Hellen, C.U.T.; Wimmer, E.
Site-directed mutagenesis of the putative catalytic triad of poliovirus 3C proteinase
J. Biol. Chem.
266
5412-5416
1991
Enterovirus C, Enterovirus C Sabin
Miyashita, K.; Kusumi, M.; Utsumi, R.; Katayama, S.; Noda, M.; Komano, T.; Satoh, N.
Site-directed mutagenesis of the putative active site residues of 3C proteinase of coxsackievirus B3: evidence of a functional relationship with trypsin-like serine proteinases
Protein Eng.
6
189-193
1993
coxsackievirus
Polgar, L.; Erdelyi, F.; Hajnal, E.; Low, M.; Graf, L.; Korant, B.D.
Separation of native and truncated forms of poliovirus protease 3C produced in Escherichia coli
Biochem. J.
290
797-800
1993
Enterovirus C
Leong, L.E.C.; Walker, P.A.; Porter, A.G.
Human rhinovirus-14 protease 3C (3Cpro) binds specifically to the 5-noncoding region of the viral RNA. Evidence that 3Cpro has different domains for the RNA binding and proteolytic activities
J. Biol. Chem.
268
25735-25739
1993
enterovirus
Bablanian, G.M.; Grubman, M.J.
Characterization of the foot-and-mouth disease virus 3C protease expressed in Escherichia coli
Virology
197
320-327
1993
Foot-and-mouth disease virus
Chernaia, M.M.; Malcolm, B.A.; Allaire, M.; James, M.N.G.
Hepatitis A virus 3C proteinase: some properties, crystallization and preliminary crystallographic characterization
J. Mol. Biol.
234
890-893
1993
Hepatovirus A
Skern, T.; Liebig, H.D.
Picornains 2A and 3C
Methods Enzymol.
244
583-595
1994
coxsackievirus, echovirus, Encephalomyocarditis virus, enterovirus, Foot-and-mouth disease virus, Hepatovirus A, Mengo virus, picornaviridae, Enterovirus C, Theiler's encephalomyelitis virus
Schultheiss, T.; Kusov, Y.Y.; Gauss-Muller, V.
Proteinase 3C of hepatitis A virus (HAV) cleaves the HAV polyprotein P2-P3 at all sites including VP1/2A and 2A/2B
Virology
198
275-281
1994
Hepatovirus A
Matthews, D.A.; Smith, W.W.; Ferre, R.A.; Condon, B.; Budahazi, G.; Sisson, W.; Villafranca, J.E.; Janson, C.A.; McElroy, H.E.; Gribskov, C.L.; Worland, S.
Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein
Cell
77
761-771
1994
enterovirus
Schultheiss, T.; Sommergruber, W.; Kusov, Y.Y.; Gauss-Müller, V.
Cleavage specificity of purified recombinant hepatitis A virus 3C proteinase on natural substrates
J. Virol.
69
1727-1733
1995
Hepatovirus A
Allaire, M.; Chernaia, M.M.; Malcolm, B.A.; James, M.N.G.
Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases
Nature
369
72-76
1994
Hepatovirus A
Kreisberg, R.; Shocken, M.; Schomburg, D.; Arad, D.
Mechanistic and structural features of the picornaviral 3C protease
Spec. Publ. -R. Soc. Chem.
148
110-122
1995
picornaviridae
-
Pallai, P.V.; Burkhardt, F.; Skoog, M.; Schreiner, K.; Bax, P.; Cohen, K.A.; Hansen, G.; Palladino, D.E.H.; Harris, K.S.; Nicklin, M.J.; Wimmer, E.
Cleavage of synthetic peptides by purified poliovirus 3C proteinase
J. Biol. Chem.
264
9738-9741
1989
Enterovirus C
Grubman, M.J.; Zellner, M.; Bablanian, G.; Mason, P.W.; Piccone, M.E.
Identification of the active-site residues of the 3C proteinase of foot-and-mouth disease virus
Virology
213
581-589
1995
Foot-and-mouth disease virus
Malcolm, B.A.; Lowe, C.; Shechosky, S.; McKay, R.T.; Yang, C.C.; Shah, V.J.; Simon, R.J.; Vederas, J.C.; Santi, D.V.
Peptide aldehyde inhibitors of hepatitis A virus 3C proteinase
Biochemistry
34
8172-8179
1995
enterovirus, Hepatovirus A
Miyashita, K.; Okunishi, J.; Utsumi, R.; Komano, T.; Tamura, T.; Satoh, N.
Cleavage specificity of coxsackievirus 3C proteinase for peptide substrate
Biosci. Biotechnol. Biochem.
60
705-707
1996
coxsackievirus
Malcolm, B.A.
The picornaviral 3C proteinases: cysteine nucleophiles in serine proteinase folds
Protein Sci.
4
1439-1445
1995
picornaviridae
Hill, R.D.; Vederas, J.C.
Azodicarboxamides: a new class of cysteien proteinase inhibitor for hepatitis A virus and human thinovirus 3C enzymes
J. Org. Chem.
64
9538-9546
1999
enterovirus, Hepatovirus A
-
Davis, G.J.; Wang, Q.M.; Cox, G.A.; Johnson, R.B.; Wakulchik, M.; Dotson, C.A.; Villarreal, E.C.
Expression and purification of recombinant rhinovirus 14 3CD proteinase and its comparison to the 3C proteinase
Arch. Biochem. Biophys.
346
125-130
1997
enterovirus
Morris, T.S.; Frormann, S.; Shechosky, S.; Lowe, C.; Lall, M.S.; Gauss-Muller, V.; Purcell, R.H.; Emerson, S.U.; Vederas, J.C.; Malcolm, B.A.
In vitro and ex vivo inhibition of hepatitis A virus 3C proteinase by a peptidyl monofluoromethyl ketone
Bioorg. Med. Chem.
5
797-807
1997
Hepatovirus A
Huang, Y.; Malcolm, B.A.; Vederas, J.C.
Synthesis and testing of azaglutamine derivatives as inhibitors of hepatitis A virus (HAV) 3C proteinase
Bioorg. Med. Chem.
7
607-619
1999
coxsackievirus, Hepatovirus A
Matthews, D.A.; Dragovich, P.S.; Webber, S.E.; Fuhrman, S.A.; Patick, A.K.; Zalman, L.S.; Hendrickson, T.F.; Love, R.A.; Prins, T.J.; Marakovits, J.T.; Zhou, R.; Tikhe, J.; Ford, C.E.; Meador, J.W.; Ferre, R.A.; Brown, E.L.; Binford, S.L.; Brothers, M.A.; DeLisle, D.M.; Worland, S.T.
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
Proc. Natl. Acad. Sci. USA
96
11000-11007
1999
enterovirus
Johnson, T.O.; Hua, Y.; Luu, H.T.; Brown, E.L.; Chan, F.; Chu, S.S.; Dragovich, P.S.; Eastman, B.W.; Ferre, R.A.; Fuhrman, S.A.; Hendrickson, T.F.; Maldonado, F.C.; Matthews, D.A.; Meador, J.W., 3rd; Patick, A.K.; Reich, S.H.; Skalitzky, D.J.; Worland, S.T.; Yang, M.; Zalman, L.S.
Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease
J. Med. Chem.
45
2016-2023
2002
enterovirus
Zalman, L.S.; Brothers, M.A.; Dragovich, P.S.; Zhou, R.; Prins, T.J.; Worland, S.T.; Patick, A.K.
Inhibition of human rhinovirus-induced cytokine production by AG7088, a human rhinovirus 3C protease inhibitor
Antimicrob. Agents Chemother.
44
1236-1241
2000
enterovirus
Patick, A.K.; Binford, S.L.; Brothers, M.A.; Jackson, R.L.; Ford, C.E.; Diem, M.D.; Maldonado, F.; Dragovich, P.S.; Zhou, R.; Prins, T.J.; Fuhrman, S.A.; Meador, J.W.; Zalman, L.S.; Matthews, D.A.; Worland, S.T.
In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease
Antimicrob. Agents Chemother.
43
2444-2450
1999
enterovirus
Sarkany, Z.; Polgar, L.
The unusual catalytic triad of poliovirus protease 3C
Biochemistry
42
516-522
2003
Enterovirus C
Lall, M.S.; Ramtohul, Y.K.; James, M.N.; Vederas, J.C.
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors
J. Org. Chem.
67
1536-1547
2002
Hepatovirus A
Webber, S.E.; Okano, K.; Little, T.L.; Reich, S.H.; Xin, Y.; Fuhrman, S.A.; Matthews, D.A.; Love, R.A.; Hendrickson, T.F.; Patick, A.K.; Meador, J.W., 3rd; Ferre, R.A.; Brown, E.L.; Ford, C.E.; Binford, S.L.; Worland, S.T.
Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements
J. Med. Chem.
41
2786-2805
1998
enterovirus
Gosert, R.; Dollenmaier, G.; Weitz, M.
Identification of active-site residues in protease 3C of hepatitis A virus by site-directed mutagenesis
J. Virol.
71
3062-3068
1997
Hepatovirus A
Hata, S.; Sato, T.; Sorimachi, H.; Ishiura, S.; Suzuki, K.
A simple purification and fluorescent assay method of the poliovirus 3C protease searching for specific inhibitors
J. Virol. Methods
84
117-126
2000
Enterovirus C
Belsham, G.J.; McInerney, G.M.; Ross-Smith, N.
Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells
J. Virol.
74
272-280
2000
Foot-and-mouth disease virus
Birtley, J.R.; Curry, S.
Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy
Acta Crystallogr. Sect. D
61
646-650
2005
Foot-and-mouth disease virus
Binford, S.L.; Maldonado, F.; Brothers, M.A.; Weady, P.T.; Zalman, L.S.; Meador, J.W.; Matthews, D.A.; Patick, A.K.
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor
Antimicrob. Agents Chemother.
49
619-626
2005
enterovirus, Human rhinovirus sp., enterovirus CVB2
Bergmann, E.M.
Hepatitis A virus picornain 3C
Handbook of proteolytic enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,eds. )Academic Press
2
1373-1376
2004
Hepatovirus A
-
Birtley, J.R.; Knox, S.R.; Jaulent, A.M.; Brick, P.; Leatherbarrow, R.J.; Curry, S.
Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity
J. Biol. Chem.
280
11520-11527
2005
Foot-and-mouth disease virus, Foot-and-mouth disease virus A10_61
Shih, S.R.; Chiang, C.; Chen, T.C.; Wu, C.N.; Hsu, J.T.; Lee, J.C.; Hwang, M.J.; Li, M.L.; Chen, G.W.; Ho, M.S.
Mutations at KFRDI and VGK domains of enterovirus 71 3C protease affect its RNA binding and proteolytic activities
J. Biomed. Sci.
11
239-248
2004
enterovirus
Steindl, T.; Laggner, C.; Langer, T.
Human rhinovirus 3C protease: generation of pharmacophore models for peptidic and nonpeptidic inhibitors and their application in virtual screening
J. Chem. Inf. Model.
45
716-724
2005
Human rhinovirus sp.
Strong, R.; Belsham, G.J.
Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site
J. Gen. Virol.
85
2953-2962
2004
Foot-and-mouth disease virus
Amineva, S.P.; Aminev, A.G.; Palmenberg, A.C.; Gern, J.E.
Rhinovirus 3C protease precursors 3CD and 3CD' localize to the nuclei of infected cells
J. Gen. Virol.
85
2969-2979
2004
Human rhinovirus sp.
Yin, J.; Bergmann, E.M.; Cherney, M.M.; Lall, M.S.; Jain, R.P.; Vederas, J.C.; James, M.N.
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site
J. Mol. Biol.
354
854-871
2005
Hepatovirus A
Banerjee, R.; Weidman, M.K.; Echeverri, A.; Kundu, P.; Dasgupta, A.
Regulation of poliovirus 3C protease by the 2C polypeptide
J. Virol.
78
9243-9256
2004
Enterovirus C
Kuyumcu-Martinez, N.M.; Van Eden, M.E.; Younan, P.; Lloyd, R.E.
Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: a novel mechanism for host translation shutoff
Mol. Cell. Biol.
24
1779-1790
2004
Enterovirus C
Hedhammar, M.; Jung, H.R.; Hober, S.
Enzymatic cleavage of fusion proteins using immobilised protease 3C
Protein Expr. Purif.
47
422-426
2006
coxsackievirus
Ohlenschlaeger, O.; Wohnert, J.; Bucci, E.; Seitz, S.; Hafner, S.; Ramachandran, R.; Zell, R.; Goerlach, M.
The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C
Structure
12
237-248
2004
coxsackievirus, coxsackievirus CVB3
Lee, J.C.; Shih, S.R.; Chang, T.Y.; Tseng, H.Y.; Shih, Y.F.; Yen, K.J.; Chen, W.C.; Shie, J.J.; Fang, J.M.; Liang, P.H.; Chao, Y.S.; Hsu, J.T.
A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71
Anal. Biochem.
375
115-123
2008
Enterovirus A71
Chau, D.H.; Yuan, J.; Zhang, H.; Cheung, P.; Lim, T.; Liu, Z.; Sall, A.; Yang, D.
Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1
Apoptosis
12
513-524
2007
Coxsackievirus B3
Lee, E.S.; Lee, W.G.; Yun, S.H.; Rho, S.H.; Im, I.; Yang, S.T.; Sellamuthu, S.; Lee, Y.J.; Kwon, S.J.; Park, O.K.; Jeon, E.S.; Park, W.J.; Kim, Y.C.
Development of potent inhibitors of the coxsackievirus 3C protease
Biochem. Biophys. Res. Commun.
358
7-11
2007
Coxsackievirus B3
Gouvea, I.E.; Judice, W.A.; Cezari, M.H.; Juliano, M.A.; Juhasz, T.; Szeltner, Z.; Polgar, L.; Juliano, L.
Kosmotropic salt activation and substrate specificity of poliovirus protease 3C
Biochemistry
45
12083-12089
2006
Enterovirus C
Bjorndahl, T.C.; Andrew, L.C.; Semenchenko, V.; Wishart, D.S.
NMR solution structures of the apo and peptide-inhibited human rhinovirus 3C protease (Serotype 14): structural and dynamic comparison
Biochemistry
46
12945-12958
2007
Human rhinovirus sp.
Wanga, Q.M.; Chen, S.H.
Human rhinovirus 3C protease as a potential target for the development of antiviral agents
Curr. Protein Pept. Sci.
8
19-27
2007
Human rhinovirus sp.
Curry, S.; Roque-Rosell, N.; Zunszain, P.A.; Leatherbarrow, R.J.
Foot-and-mouth disease virus 3C protease: Recent structural and functional insights into an antiviral target
Int. J. Biochem. Cell Biol.
39
1-6
2006
Foot-and-mouth disease virus
Soderholm, J.; Sallberg, M.
A complete mutational fitness map of the hepatitis C virus nonstructural 3 protease: Relation to recognition by cytotoxic T lymphocytes
J. Infect. Dis.
194
1724-1728
2006
Hepacivirus C
Yin, J.; Cherney, M.M.; Bergmann, E.M.; Zhang, J.; Huitema, C.; Pettersson, H.; Eltis, L.D.; Vederas, J.C.; James, M.N.
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors
J. Mol. Biol.
361
673-686
2006
Hepatovirus A
Sweeney, T.R.; Roque-Rosell, N.; Birtley, J.R.; Leatherbarrow, R.J.; Curry, S.
Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis
J. Virol.
81
115-124
2007
Foot-and-mouth disease virus, Foot-and-mouth disease virus A1061
Zheng, M.; Jin, N.; Zhang, H.; Jin, M.; Lu, H.; Ma, M.; Li, C.; Yin, G.; Wang, R.; Liu, Q.
Construction and immunogenicity of a recombinant fowlpox virus containing the capsid and 3C protease coding regions of foot-and-mouth disease virus
J. Virol. Methods
136
230-237
2006
Foot-and-mouth disease virus, Foot-and-mouth disease virus O/NY00
Maugeri, C.; Alisi, M.A.; Apicella, C.; Cellai, L.; Dragone, P.; Fioravanzo, E.; Florio, S.; Furlotti, G.; Mangano, G.; Ombrato, R.; Luisi, R.; Pompei, R.; Rincicotti, V.; Russo, V.; Vitiello, M.; Cazzolla, N.
New anti-viral drugs for the treatment of the common cold
Bioorg. Med. Chem.
16
3091-3107
2008
Human rhinovirus sp.
Huitema, C.; Zhang, J.; Yin, J.; James, M.N.; Vederas, J.C.; Eltis, L.D.
Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action
Bioorg. Med. Chem.
16
5761-5777
2008
Hepatovirus A
Kuo, C.J.; Shie, J.J.; Fang, J.M.; Yen, G.R.; Hsu, J.T.; Liu, H.G.; Tseng, S.N.; Chang, S.C.; Lee, C.Y.; Shih, S.R.; Liang, P.H.
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents
Bioorg. Med. Chem.
16
7388-7398
2008
enterovirus
Shen, M.; Reitman, Z.J.; Zhao, Y.; Moustafa, I.; Wang, Q.; Arnold, J.J.; Pathak, H.B.; Cameron, C.E.
Picornavirus genome replication: identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex
J. Biol. Chem.
283
875-888
2008
picornaviridae
Bonderoff, J.M.; Larey, J.L.; Lloyd, R.E.
Cleavage of poly(A)-binding protein by poliovirus 3C proteinase inhibits viral internal ribosome entry site-mediated translation
J. Virol.
82
9389-9399
2008
Enterovirus C
Lu, Z.; Bao, H.; Cao, Y.; Sun, P.; Guo, J.; Li, P.; Bai, X.; Chen, Y.; Xie, B.; Li, D.; Liu, Z.; Xie, Q.
Protection of guinea pigs and swine by a recombinant adenovirus expressing O serotype of foot-and-mouth disease virus whole capsid and 3C protease
Vaccine
26 Suppl 6
G48-G53
2008
picornaviridae
Rivera, C.I.; Lloyd, R.E.
Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors
Virology
375
59-72
2008
Enterovirus C
de Breyne, S.; Bonderoff, J.M.; Chumakov, K.M.; Lloyd, R.E.; Hellen, C.U.
Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases
Virology
378
118-122
2008
coxsackievirus, Enterovirus C
Klopfleisch, C.; Minh, L.Q.; Giesow, K.; Curry, S.; Keil, G.M.
Effect of foot-and-mouth disease virus capsid precursor protein and 3C protease expression on bovine herpesvirus 1 replication
Arch. Virol.
155
723-731
2010
Bovine alphaherpesvirus 1, Bovine alphaherpesvirus 1 Schoenboeken, Foot-and-mouth disease virus, Foot-and-mouth disease virus A Iran 97
Im, I.; Lee, E.S.; Choi, S.J.; Lee, J.Y.; Kim, Y.C.
Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors
Bioorg. Med. Chem. Lett.
19
3632-3636
2009
Human rhinovirus sp.
Zunszain, P.A.; Knox, S.R.; Sweeney, T.R.; Yang, J.; Roque-Rosell, N.; Belsham, G.J.; Leatherbarrow, R.J.; Curry, S.
Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate
J. Mol. Biol.
395
375-389
2010
Foot-and-mouth disease virus
Ghildyal, R.; Jordan, B.; Li, D.; Dagher, H.; Bardin, P.G.; Gern, J.E.; Jans, D.A.
Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport
J. Virol.
83
7349-7352
2009
Human rhinovirus sp.
Lei, X.; Liu, X.; Ma, Y.; Sun, Z.; Yang, Y.; Jin, Q.; He, B.; Wang, J.
The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses
J. Virol.
84
8051-8061
2010
Enterovirus A71
Weng, K.F.; Li, M.L.; Hung, C.T.; Shih, S.R.
Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation
PLoS Pathog.
5
e1000593
2009
Enterovirus A71
Hussey, R.J.; Coates, L.; Gill, R.S.; Erskine, P.T.; Coker, S.F.; Mitchell, E.; Cooper, J.B.; Wood, S.; Broadbridge, R.; Clarke, I.N.; Lambden, P.R.; Shoolingin-Jordan, P.M.
A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor
Biochemistry
50
240-249
2010
Southampton virus (Q04544)
Gouvea, I.E.; Santos, J.A.; Burlandy, F.M.; Tersariol, I.L.; da Silva, E.E.; Juliano, M.A.; Juliano, L.; Cunha, R.L.
Poliovirus 3C proteinase inhibition by organotelluranes
Biol. Chem.
392
587-591
2011
Human poliovirus 3
Tiew, K.C.; He, G.; Aravapalli, S.; Mandadapu, S.R.; Gunnam, M.R.; Alliston, K.R.; Lushington, G.H.; Kim, Y.; Chang, K.O.; Groutas, W.C.
Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease
Bioorg. Med. Chem. Lett.
21
5315-5319
2011
Norwalk virus
Baxter, A.; Chambers, M.; Edfeldt, F.; Edman, K.; Freeman, A.; Johansson, C.; King, S.; Morley, A.; Petersen, J.; Rawlins, P.; Spadola, L.; Thong, B.; Van de Poel, H.; Williams, N.
Non-covalent inhibitors of rhinovirus 3C protease
Bioorg. Med. Chem. Lett.
21
777-780
2011
rhinovirus A2
Ramajayam, R.; Tan, K.P.; Liu, H.G.; Liang, P.H.
Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors
Bioorg. Med. Chem.
18
7849-7854
2010
Severe acute respiratory syndrome-related coronavirus, Coxsackievirus B3
Wang, J.; Fan, T.; Yao, X.; Wu, Z.; Guo, L.; Lei, X.; Wang, J.; Wang, M.; Jin, Q.; Cui, S.
Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues
J. Virol.
85
10021-10030
2011
Enterovirus A71 (E9LTP4)
Lu, G.; Qi, J.; Chen, Z.; Xu, X.; Gao, F.; Lin, D.; Qian, W.; Liu, H.; Jiang, H.; Yan, J.; Gao, G.F.
Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design
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