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Literature summary for 3.4.22.28 extracted from

  • Weng, K.F.; Li, M.L.; Hung, C.T.; Shih, S.R.
    Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation (2009), PLoS Pathog., 5, e1000593.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Enterovirus A71
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CstF-64 protein + H2O CstF-64 protein is short for cleavage stimulation factor, 39 pre-RNA, subunit 2, 64 kD. The 3Cpro cleavage sites are located at position 251 in the N-terminal P/G-rich domain and at multiple positions close to the C-terminus of CstF-64 (around position 500) Enterovirus A71 ?
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additional information picornavirus 3Cpro generally cleaves peptides at the Gln/Gly junction Enterovirus A71 ?
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Synonyms

Synonyms Comment Organism
3C protease
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Enterovirus A71
3Cpro
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Enterovirus A71

General Information

General Information Comment Organism
physiological function 3Cpro cleavage inactivates CstF-64 and impairs the host cell polyadenylation in vitro, as well as in virus-infected cells Enterovirus A71