Protein Variants | Comment | Organism |
---|---|---|
C147A | inactive mutant does not induce the appearance of a MAVS cleavage product | Coxsackievirus B3 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitochondrial antiviral signaling protein + H2O | Coxsackievirus B3 | 3Cpro-mediated MAVS cleavage occurs within its proline-rich region, leads to its relocalization from the mitochondrial membrane, and ablates its downstream signaling | ? | - |
? | |
Toll/IL-1 receptor domain-containing adaptor inducing interferon-beta + H2O | Coxsackievirus B3 | 3Cpro cleaves both the N- and C-terminal domains of TRIF and localizes with TRIF to signalosome complexes within the cytoplasm | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Coxsackievirus B3 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitochondrial antiviral signaling protein + H2O | 3Cpro-mediated MAVS cleavage occurs within its proline-rich region, leads to its relocalization from the mitochondrial membrane, and ablates its downstream signaling | Coxsackievirus B3 | ? | - |
? | |
Toll/IL-1 receptor domain-containing adaptor inducing interferon-beta + H2O | 3Cpro cleaves both the N- and C-terminal domains of TRIF and localizes with TRIF to signalosome complexes within the cytoplasm | Coxsackievirus B3 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3Cpro protease | - |
Coxsackievirus B3 |
General Information | Comment | Organism |
---|---|---|
physiological function | infection of cells with coxsackievirus leads to the cleavage of the adaptor molecules MAVS and TRIF through 3Cpro, indicating that a single protease suppresses innate immune signaling through two pathways. 3Cpro cleaves specific residues within MAVS and TRIF that render these molecules deficient in type I IFN signaling and apoptotic signaling | Coxsackievirus B3 |