Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-diphenyl-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Coxsackievirus B3 | |
1,3-diphenyl-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-phenyl-1-(3,4-dichlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Coxsackievirus B3 | |
3-phenyl-1-(3,4-dichlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-phenyl-1-(3-chlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Coxsackievirus B3 | |
3-phenyl-1-(3-chlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-phenyl-1-(3-nitrophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | - |
Coxsackievirus B3 | |
3-phenyl-1-(3-nitrophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-phenyl-1-(4-chlorophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | - |
Coxsackievirus B3 | |
3-phenyl-1-(4-chlorophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-phenyl-1-(4-cyanophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | - |
Coxsackievirus B3 | |
3-phenyl-1-(4-cyanophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-phenyl-1-(4-fluorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Coxsackievirus B3 | |
3-phenyl-1-(4-fluorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-phenyl-1-(4-methoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Coxsackievirus B3 | |
3-phenyl-1-(4-methoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Severe acute respiratory syndrome-related coronavirus | |
3-phenyl-1-(4-trifluoromethoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Coxsackievirus B3 | |
3-phenyl-1-(4-trifluoromethoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | - |
Severe acute respiratory syndrome-related coronavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Coxsackievirus B3 | - |
- |
- |
Severe acute respiratory syndrome-related coronavirus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Dabcyl-KTSAVLQSGFRKME-EDANS + H2O | - |
Severe acute respiratory syndrome-related coronavirus | Dabcyl-KTSAVL + QSGFRKME-EDANS | - |
? | |
Dabcyl-KTSAVLQSGFRKME-EDANS + H2O | - |
Coxsackievirus B3 | Dabcyl-KTSAVL + QSGFRKME-EDANS | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3C-like protease | - |
Severe acute respiratory syndrome-related coronavirus |
3C-like protease | - |
Coxsackievirus B3 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Severe acute respiratory syndrome-related coronavirus |
25 | - |
assay at | Coxsackievirus B3 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Severe acute respiratory syndrome-related coronavirus |
7 | - |
assay at | Coxsackievirus B3 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.005 | - |
pH 7, 25°C | Severe acute respiratory syndrome-related coronavirus | 3-phenyl-1-(4-cyanophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | |
0.0068 | - |
pH 7, 25°C | Severe acute respiratory syndrome-related coronavirus | 3-phenyl-1-(4-fluorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.0084 | - |
pH 7, 25°C | Severe acute respiratory syndrome-related coronavirus | 3-phenyl-1-(3-nitrophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | |
0.0096 | - |
pH 7, 25°C | Coxsackievirus B3 | 3-phenyl-1-(3-nitrophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | |
0.01 | - |
pH 7, 25°C | Severe acute respiratory syndrome-related coronavirus | 3-phenyl-1-(3-chlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.012 | - |
pH 7, 25°C | Severe acute respiratory syndrome-related coronavirus | 3-phenyl-1-(4-methoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.013 | - |
pH 7, 25°C | Severe acute respiratory syndrome-related coronavirus | 3-phenyl-1-(4-chlorophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | |
0.0166 | - |
pH 7, 25°C | Coxsackievirus B3 | 3-phenyl-1-(4-methoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.017 | - |
pH 7, 25°C | Coxsackievirus B3 | 3-phenyl-1-(3-chlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.018 | - |
pH 7, 25°C | Severe acute respiratory syndrome-related coronavirus | 1,3-diphenyl-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.02 | - |
pH 7, 25°C | Coxsackievirus B3 | 3-phenyl-1-(4-cyanophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | |
0.022 | - |
pH 7, 25°C | Coxsackievirus B3 | 3-phenyl-1-(4-fluorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.024 | - |
pH 7, 25°C | Severe acute respiratory syndrome-related coronavirus | 3-phenyl-1-(3,4-dichlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.025 | - |
pH 7, 25°C | Coxsackievirus B3 | 3-phenyl-1-(4-chlorophenyl)-4-(4-carboxybenzylidene)-pyrazol-5(4H)-one | |
0.042 | - |
pH 7, 25°C | Severe acute respiratory syndrome-related coronavirus | 3-phenyl-1-(4-trifluoromethoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.051 | - |
pH 7, 25°C | Coxsackievirus B3 | 1,3-diphenyl-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.098 | - |
pH 7, 25°C | Coxsackievirus B3 | 3-phenyl-1-(4-trifluoromethoxyphenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one | |
0.125 | - |
pH 7, 25°C | Coxsackievirus B3 | 3-phenyl-1-(3,4-dichlorophenyl)-4-(4-carboxybenzylidene)pyrazol-5(4H)-one |