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3.4.22.28: picornain 3C

This is an abbreviated version!
For detailed information about picornain 3C, go to the full flat file.

Word Map on EC 3.4.22.28

Reaction

Selective cleavage of Gln-/-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly =

Synonyms

3C protease, 3C protein, 3C proteinase, 3C-like protease, 3C-protease, 3CL, 3cLpro, 3CP, 3Cpro, 3Cpro protease, Avihepatovirus 3C protease, coxsackievirus 3C proteinase, cysteine proteinase 3C, DHAV 3C protease, enterovirus 3C protease, EV71 3Cpro, foot-and-mouth protease 3C, HAC 3C, HAV 3C protease, HAV 3Cpro, hepatitis A virus 3C proteinase, HRV 3C protease, HRV 3Cpro, HRV type-14 3C protease, HRV16 3C protease, Human rhinovirus 3C protease, human rhinovirus type-14 3C protease, nonstructural 3 protease, NS3 protease, NS6 protease, P3C, picornain 3C, picornain-3C, picornaviral 3C protease, picornavirus endopeptidase 3C, poliovirus protease 3C, poliovirus proteinase 3C, protease 3C, proteinase, foot-and-mouth-disease virus, 3C, proteinase, picornavirus, 3C, proteinase, poliovirus, 3C, proteinase, rhinovirus, 3C, rhinovirus 3C protease, rhinovirus protease 3C, SAT-type 3C protease, Senecavirus A 3C protease, SV3CP, SVA 3Cpro, tomato ringspot nepovirus 3C-related protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.28 picornain 3C

Natural Substrates Products

Natural Substrates Products on EC 3.4.22.28 - picornain 3C

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
activated transcription factor TFIIIC + H2O
?
show the reaction diagram
-
in HeLa-cells, poliovirus enzyme, involved in shut-off of host-cell transcription
-
-
?
ERGIC53 protein + H2O
?
show the reaction diagram
-
-
-
-
?
eukaryotic initiation factor + H2O
eukaryotic initiation factor 1-478 + eukaryotic initiation factor 479-?
show the reaction diagram
foot-and-mouth disease virus capsid precursor (P1-2A) + H2O
foot-and-mouth disease virus protein VP0 + foot-and-mouth disease virus protein VP3 + foot-and-mouth disease virus protein VP1 + foot-and-mouth disease virus protein 2A
show the reaction diagram
-
cleavages at the three junctions (VP0/VP3, VP3/VP1, and VP1/2A) within the foot-and-mouth disease virus capsid precursor (P1-2A) by the 3C protease are mutually independent
-
-
?
hepatitis A virus polyprotein + H2O
?
show the reaction diagram
host zinc-finger antiviral protein + H2O
?
show the reaction diagram
-
cleavage specifically at Gln369, ZAP cleavage is dependent on its amino acid pair Q369 and G370
-
-
?
interferon regulatory factor 7 + H2O
?
show the reaction diagram
-
cleavage occurs at the Q189-S190 junction within the constitutive activation domain
-
-
?
membrin + H2O
?
show the reaction diagram
-
-
-
-
?
mitochondrial antiviral signaling protein + H2O
?
show the reaction diagram
-
3Cpro-mediated MAVS cleavage occurs within its proline-rich region, leads to its relocalization from the mitochondrial membrane, and ablates its downstream signaling
-
-
?
nuclear factor-kappaB essential modulator + H2O
?
show the reaction diagram
-
the enzyme cleaves the substrate at the Q304 residue, negating its signaling adaptor function
-
-
?
picornavirus polyprotein + H2O
hydrolyzed picornavirus polyprotein
show the reaction diagram
poliovirus polyprotein + H2O
hydrolyzed poliovirus polyprotein
show the reaction diagram
poly(A) binding protein + H2O
?
show the reaction diagram
-
the enzyme cleaves poly(A) binding protein within the C-terminal domain at Q437/G438
-
-
?
poly(A) binding protein + H2O
fragments of poly(A) binding protein
show the reaction diagram
-
contains 2 main cleavage sites for 3C proteinase within the proline-rich linker domain, cleavage of recombinant protein with 3C proteinase heavily favors the 3Cpro primary cleavage site Q537/G538 over the 3CAlt cleavage site Q413/T414
-
-
?
poly(A)-binding protein + H2O
fragments of poly(A)-binding protein
show the reaction diagram
-
inhibition of viral internal ribosome entry site-mediated translation, cleavage of poly(A)-binding protein by 3Cpro is a necessary component for host translation shutoff
-
-
?
Ras-GTPase activating protein SH3 domain-binding protein 1 + H2O
fragments of Ras-GTPase activating protein SH3 domain-binding protein 1
show the reaction diagram
-
-
-
-
?
receptor-interacting protein kinase 1 + H2O
?
show the reaction diagram
-
cleavage of the RIPK1 death-domain, and generation of N-terminal RIPK1 fragments
-
-
?
receptor-interacting protein kinase-1 + H2O
?
show the reaction diagram
i.e. RIPK1
-
-
?
Thr-Gly-Leu-Phe-Gln-Gly-Pro + H2O
Thr-Gly-Leu-Phe-Gln + Gly-Pro
show the reaction diagram
-
-
-
-
?
Toll/IL-1 receptor domain-containing adaptor inducing interferon-beta + H2O
?
show the reaction diagram
-
3Cpro cleaves both the N- and C-terminal domains of TRIF and localizes with TRIF to signalosome complexes within the cytoplasm
-
-
?
TRIF protein + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-