Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli or BL21(D3) | Enterovirus C |
expressed in HeLa cells | Foot-and-mouth disease virus |
expressed in HeLa cells | Enterovirus C |
expressed in HeLa cells | Encephalomyocarditis virus |
expressed in HeLa cells | enterovirus |
expressed in HeLa cells | Hepatovirus A |
expressed in HeLa cells | coxsackievirus |
expressed in HeLa cells | echovirus |
expressed in HeLa cells | Mengo virus |
expressed in HeLa cells | Theiler's encephalomyelitis virus |
expressed in HeLa cells | picornaviridae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chymostatin | - |
enterovirus | |
Elastinal | - |
enterovirus | |
Hg2+ | - |
coxsackievirus | |
Hg2+ | - |
echovirus | |
Hg2+ | - |
Encephalomyocarditis virus | |
Hg2+ | - |
enterovirus | |
Hg2+ | - |
Enterovirus C | |
Hg2+ | - |
Foot-and-mouth disease virus | |
Hg2+ | - |
Hepatovirus A | |
Hg2+ | - |
Mengo virus | |
Hg2+ | - |
picornaviridae | |
Hg2+ | - |
Theiler's encephalomyelitis virus | |
iodoacetamide | - |
coxsackievirus | |
iodoacetamide | - |
echovirus | |
iodoacetamide | - |
Encephalomyocarditis virus | |
iodoacetamide | - |
enterovirus | |
iodoacetamide | - |
Enterovirus C | |
iodoacetamide | - |
Foot-and-mouth disease virus | |
iodoacetamide | - |
Hepatovirus A | |
iodoacetamide | - |
Mengo virus | |
iodoacetamide | - |
picornaviridae | |
iodoacetamide | - |
Theiler's encephalomyelitis virus | |
additional information | no inhibition by Triton X-100, that inhibits picornain 3CD | enterovirus | |
additional information | - |
Enterovirus C | |
NEM | - |
coxsackievirus | |
NEM | - |
echovirus | |
NEM | - |
Encephalomyocarditis virus | |
NEM | - |
enterovirus | |
NEM | - |
Enterovirus C | |
NEM | - |
Foot-and-mouth disease virus | |
NEM | - |
Hepatovirus A | |
NEM | - |
Mengo virus | |
NEM | - |
picornaviridae | |
NEM | - |
Theiler's encephalomyelitis virus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.25 | 2.6 | peptides derived from polyprotein cleavage sites | - |
enterovirus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | recombinant enzyme | Foot-and-mouth disease virus | 16020 | - |
membrane | recombinant enzyme | Enterovirus C | 16020 | - |
membrane | recombinant enzyme | Encephalomyocarditis virus | 16020 | - |
membrane | recombinant enzyme | enterovirus | 16020 | - |
membrane | recombinant enzyme | Hepatovirus A | 16020 | - |
membrane | recombinant enzyme | coxsackievirus | 16020 | - |
membrane | recombinant enzyme | echovirus | 16020 | - |
membrane | recombinant enzyme | Mengo virus | 16020 | - |
membrane | recombinant enzyme | Theiler's encephalomyelitis virus | 16020 | - |
membrane | recombinant enzyme | picornaviridae | 16020 | - |
membrane | rhinovirus, expressed in Escherichia coli | enterovirus | 16020 | - |
soluble | recombinant enzyme | Foot-and-mouth disease virus | - |
- |
soluble | recombinant enzyme | Enterovirus C | - |
- |
soluble | recombinant enzyme | Encephalomyocarditis virus | - |
- |
soluble | recombinant enzyme | enterovirus | - |
- |
soluble | recombinant enzyme | Hepatovirus A | - |
- |
soluble | recombinant enzyme | coxsackievirus | - |
- |
soluble | recombinant enzyme | echovirus | - |
- |
soluble | recombinant enzyme | Mengo virus | - |
- |
soluble | recombinant enzyme | Theiler's encephalomyelitis virus | - |
- |
soluble | recombinant enzyme | picornaviridae | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
activated transcription factor TFIIIC + H2O | Enterovirus C | in HeLa-cells, poliovirus enzyme, involved in shut-off of host-cell transcription | ? | - |
? | |
picornavirus polyprotein + H2O | Foot-and-mouth disease virus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | Enterovirus C | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | Encephalomyocarditis virus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | enterovirus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | Hepatovirus A | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | coxsackievirus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | echovirus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | Mengo virus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | Theiler's encephalomyelitis virus | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | picornaviridae | involved in proteolytic processing of virus polyprotein | hydrolyzed picornavirus polyprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
coxsackievirus | - |
- |
- |
echovirus | - |
- |
- |
Encephalomyocarditis virus | - |
- |
- |
enterovirus | - |
human rhinovirus | - |
Enterovirus C | - |
- |
- |
Foot-and-mouth disease virus | - |
- |
- |
Hepatovirus A | - |
- |
- |
Mengo virus | - |
- |
- |
picornaviridae | - |
overview | - |
Theiler's encephalomyelitis virus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
as expressed in Escherichia coli | enterovirus |
from Escherichia coli membrane fraction | enterovirus |
recombinant enzyme | Enterovirus C |
recombinant enzyme from Escherichia coli in soluble form | Enterovirus C |
recombinant enzyme from infected HeLa cells, to near homogeneity | Enterovirus C |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
activated transcription factor TFIIIC + H2O | in HeLa-cells, poliovirus enzyme | Enterovirus C | ? | - |
? | |
activated transcription factor TFIIIC + H2O | in HeLa-cells, poliovirus enzyme, involved in shut-off of host-cell transcription | Enterovirus C | ? | - |
? | |
cardiovirus polyprotein + H2O | - |
Foot-and-mouth disease virus | ? | - |
? | |
cardiovirus polyprotein + H2O | - |
Enterovirus C | ? | - |
? | |
cardiovirus polyprotein + H2O | - |
Encephalomyocarditis virus | ? | - |
? | |
cardiovirus polyprotein + H2O | - |
Hepatovirus A | ? | - |
? | |
cardiovirus polyprotein + H2O | - |
coxsackievirus | ? | - |
? | |
cardiovirus polyprotein + H2O | - |
echovirus | ? | - |
? | |
cardiovirus polyprotein + H2O | - |
Mengo virus | ? | - |
? | |
cardiovirus polyprotein + H2O | - |
Theiler's encephalomyelitis virus | ? | - |
? | |
cardiovirus polyprotein + H2O | - |
picornaviridae | ? | - |
? | |
cardiovirus polyprotein + H2O | cleavage specificity | enterovirus | ? | - |
? | |
encephalomyocarditis virus polyprotein + H2O | cleavage sites: Gln-Gly, Glu-Ser and Glu-Ala | Encephalomyocarditis virus | ? | - |
? | |
enterovirus polyprotein + H2O | - |
Foot-and-mouth disease virus | ? | - |
? | |
enterovirus polyprotein + H2O | - |
Enterovirus C | ? | - |
? | |
enterovirus polyprotein + H2O | - |
Encephalomyocarditis virus | ? | - |
? | |
enterovirus polyprotein + H2O | - |
Hepatovirus A | ? | - |
? | |
enterovirus polyprotein + H2O | - |
coxsackievirus | ? | - |
? | |
enterovirus polyprotein + H2O | - |
echovirus | ? | - |
? | |
enterovirus polyprotein + H2O | - |
Mengo virus | ? | - |
? | |
enterovirus polyprotein + H2O | - |
Theiler's encephalomyelitis virus | ? | - |
? | |
enterovirus polyprotein + H2O | - |
picornaviridae | ? | - |
? | |
enterovirus polyprotein + H2O | cleavage specificity | enterovirus | ? | - |
? | |
histone protein H3 + H2O | in BHK-cells, foot-and-mouth-disease virus enzyme | Foot-and-mouth disease virus | ? | - |
? | |
peptides derived from polyprotein cleavage sites + H2O | - |
enterovirus | ? | - |
? | |
picornavirus polyprotein + H2O | - |
Foot-and-mouth disease virus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | - |
Enterovirus C | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | - |
Encephalomyocarditis virus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | - |
enterovirus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | - |
Hepatovirus A | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | - |
coxsackievirus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | - |
echovirus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | - |
Mengo virus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | - |
Theiler's encephalomyelitis virus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | - |
picornaviridae | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Foot-and-mouth disease virus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Enterovirus C | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Encephalomyocarditis virus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | enterovirus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Hepatovirus A | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | coxsackievirus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | echovirus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Mengo virus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | Theiler's encephalomyelitis virus | hydrolyzed picornavirus polyprotein | - |
? | |
picornavirus polyprotein + H2O | involved in proteolytic processing of virus polyprotein | picornaviridae | hydrolyzed picornavirus polyprotein | - |
? | |
poliovirus polyprotein + H2O | initial cleavage at 2C-3A and 2B-2C, followed by 3A-3B and/or 3C-3D | Enterovirus C | hydrolyzed poliovirus polyprotein | - |
? | |
rhinovirus polyprotein + H2O | cleavage specificity | enterovirus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 8 | - |
Enterovirus C |
7 | 8 | - |
enterovirus |