3.4.21.6: coagulation factor Xa
This is an abbreviated version!
For detailed information about coagulation factor Xa, go to the full flat file.
Word Map on EC 3.4.21.6
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3.4.21.6
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anticoagulant
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bleeding
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platelet
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heparin
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fibrinogen
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thrombosis
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pt
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venous
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antithrombin
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thromboembolism
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hemorrhage
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viii
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antithrombotic
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fibrin
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rivaroxaban
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warfarin
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hemostatic
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embolism
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stroke
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intravascular
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apixaban
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d-dimers
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coagulopathy
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unfractionated
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thrombocytopenia
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fibrillation
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plasminogen
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atrial
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fibrinolysis
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transfusion
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hemophilia
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thrombus
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lupus
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chromogenic
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willebrand
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hypercoagulable
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dabigatran
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heparin-induced
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hematoma
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hirudin
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haemostasis
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antiphospholipid
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antiplatelet
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thrombin-antithrombin
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viper
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amidolytic
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k-dependent
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analysis
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rfviia
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pharmacology
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medicine
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thrombophilia
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synthesis
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fibrinopeptide
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drug development
- 3.4.21.6
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anticoagulant
- bleeding
- platelet
- heparin
- fibrinogen
- thrombosis
- pt
- venous
- antithrombin
- thromboembolism
- hemorrhage
- viii
-
antithrombotic
- fibrin
- rivaroxaban
- warfarin
-
hemostatic
- embolism
- stroke
-
intravascular
- apixaban
-
d-dimers
- coagulopathy
-
unfractionated
- thrombocytopenia
- fibrillation
- plasminogen
- atrial
-
fibrinolysis
-
transfusion
- hemophilia
- thrombus
-
lupus
-
chromogenic
- willebrand
-
hypercoagulable
- dabigatran
-
heparin-induced
- hematoma
- hirudin
-
haemostasis
-
antiphospholipid
-
antiplatelet
-
thrombin-antithrombin
- viper
-
amidolytic
-
k-dependent
- analysis
- rfviia
- pharmacology
- medicine
- thrombophilia
- synthesis
-
fibrinopeptide
- drug development
Reaction
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin =
Synonyms
activated blood-coagulation factor X, activated factor X, activated Stuart-Prower factor, autoprothrombin C, blood coagulation factor X, blood coagulation factor Xa, blood-coagulation factor X, activated, clotting factor Xa, coagulation factor X, coagulation factor Xa, f.Xa, factor X, factor Xa, Fgl2 protein, fX, FXa, FXaalpha/beta, hXa, More, oscutarin, plasma thromboplastin, procoagulant factor X, prothrombase, prothrombin activator, prothrombinase, Stuart factor, thrombokinase, thromboplastin, thromboplastin, plasma, trocarin, Trocarin prothrombin activator, VAP, Virus activating protease, Xa
ECTree
3.4.21.6 coagulation factor XaAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.21.6 - coagulation factor Xa
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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enzyme elicits a signaling response. ERK1/2 phosphorylation by factor Xa is dependent on protease-activated receptor PAR-2 cleavage and leads to fibroblast proliferation, migration, and differentiation into myofibroblasts
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factor Xa is part of the prothrombinase complex formed by factor Xa, nonenzymatic cofacor Va and Ca2+ on the phospholipid surface of platelets or endothelial cells
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annexin 2 acts as a receptor for factor Xa on the cell surface. It facilitates factor Xa activation of receptor PAR-1 but does not enhance coagulant function of factor Xa. Overexpression of tissue factor abolishes annexin 2 dependence on factor Xa signaling and diminishes binding to cell surface annexin 2, whereas selectively abolishing tissue factor promotes the annexin 2/factor Xa interaction
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murine model of ovalbumin-induced asthma, factor X transcript levels and factor Xa activity are increased in lungs of asthmatic mice
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enzyme elicits a signaling response. ERK1/2 phosphorylation by factor Xa is dependent on protease-activated receptor PAR-2 cleavage and leads to fibroblast proliferation, migration, and differentiation into myofibroblasts
additional information
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factor Xa is part of the prothrombinase complex formed by factor Xa, nonenzymatic cofacor Va and Ca2+ on the phospholipid surface of platelets or endothelial cells
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coagulation factors from plasma bind to tissue factor TF-expressing cells, e.g. lung fibroblast, become activated, dissociate, and diffuse into plasma to form enzymatic complexes on the membranes of activated platelets, overview
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651189, 652349, 652728, 653979, 683629, 696276, 696303, 696712, 696928, 696937, 697301, 697304, 698745, 698777, 698820, 699091, 699865, 701285, 701294, 710601, 710607, 717335, 717336, 717339, 717974
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factor Xa and 5-dimethylaminonaphthalene-1-sulfonyl-(dansyl-)Glu-Gly-Arg factor Xa
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high expression level in bronchoalveolar lavage fluid macrophages from asthmatic mice
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649797, 650463, 651189, 652253, 652278, 652349, 652755, 653059, 653979, 683178, 683259, 683823, 717234
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factor Xa is part of the prothrombinase complex formed by factor Xa, nonenzymatic cofacor Va and Ca2+ on the phospholipid surface of platelets or endothelial cells
