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Literature summary for 3.4.21.6 extracted from
- Macrophages synthesize factor X and secrete factor X/Xa-containing prothrombinase activity into the surrounding medium (2000), Thromb. Haemost., 84, 429-435.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| actinomycin | no remaining enzyme activityafter 20 h | Mus musculus |  |
| cycloheximide | 61% inhibition at 0.01 mg/ml after 3 h, complete inhibition after 20 h | Mus musculus | |
| EDTA | complete inhibition at 10 mM | Mus musculus | |
| Triton X-100 | complete inactivation at 0.05% | Mus musculus | |
| vitamin K | induction of enzyme activity | Mus musculus | |
| warfarin | 62% inhibition at 0.02 mg/ml after 3 h, and 90% after 20 h | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | secretion to the medium | Mus musculus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
x * 45000, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prothrombin + H2O | Mus musculus | - |
thrombin + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | peritoneal | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prothrombin + H2O | - |
Mus musculus | thrombin + ? | - |
? | |
| S2222 + H2O | chromogenic synthetic peptide substrate | Mus musculus | ? | - |
? | |
| S2238 + H2O | chromogenic synthetic peptide substrate | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 45000, SDS-PAGE | Mus musculus |
| More | factor Xa is part of the prothrombinase complex | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Mus musculus |
| prothrombinase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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