Activating Compound | Comment | Organism | Structure |
---|---|---|---|
protein S | protein S counteracted the inhibition of activated factor V by FXa of the Arg506 cleavage, whereas protein S and FXa yielded additive stimulatory effect of the cleavage at Arg306 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
active site-mutated activated protein C | - |
Homo sapiens | |
dansyl-Glu-Gly-Arg | - |
Homo sapiens | |
protein S | protein S counteracted the inhibition of activated factor V by FXa of the Arg506 cleavage, leading to 50% reduced activity, whereas protein S and FXa yielded a 3fold additive stimulatory effect of the cleavage at Arg306, annihilation of the FXa protection of the Arg506 cleavage by protein S is due to an enhanced rate of Arg506 cleavage of FVa not bound to FXa, resulting in depletion of free FVa and dissociation of FXa-FVa complexes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | factor Xa inhibits the inhibition of the procoagulant function of activated factor V by activated protein C through proteolytic cleavages at Arg506, with a half-maximum inhibition of 2 nM, while the cleavage at Arg306, and Arg679 is not protected, protein S counteracted the inhibition by FXa of the Arg506 cleavage, whereas protein S and FXa yielded additive stimulatory effect of the cleavage at Arg306, activity with recombinant FVa Q306/Q679 and FVa Q506/Q679 variants, interaction analysis with 1.5-dansyl-Glu-Gly-Arg-inhibited factor Xa, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | factor Xa inhibits the inhibition of the procoagulant function of activated factor V by activated protein C through proteolytic cleavages at Arg506, with a half-maximum inhibition of 2 nM, while the cleavage at Arg306, and Arg679 is not protected, protein S counteracted the inhibition by FXa of the Arg506 cleavage, whereas protein S and FXa yielded additive stimulatory effect of the cleavage at Arg306, activity with recombinant FVa Q306/Q679 and FVa Q506/Q679 variants, interaction analysis with 1.5-dansyl-Glu-Gly-Arg-inhibited factor Xa, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor Xa | - |
Homo sapiens |
FXa | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
FVa inhibition assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.7 | - |
FVa inhibition assay at | Homo sapiens |