Application | Comment | Organism |
---|---|---|
medicine | glycoprotein IIb/IIIa receptor antagonists in combination with heparin might contribute to improved therapy of acute coronary syndromes abd during percutaneous coronary interventions | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
abciximab | glycoprotein IIb/IIIa receptor-antagonist, 3.8% inhibition at 0.140 mM in absence of heparin, 49% inhibition at 0.14 mM in presence of heparin 1 U/ml | Homo sapiens | |
enoxaparin | increases the inhibitory effect of abciximab and eptifibatide | Homo sapiens | |
eptifibatide | glycoprotein IIb/IIIa receptor-antagonist, 13.5% inhibition at 0.333 mM in absence of heparin, 38% inhibition at 0.14 mM in presence of heparin 1 U/ml | Homo sapiens | |
heparin | highly increases the inhibitory effects of glycoprotein IIb/IIIa receptor-antagonists | Homo sapiens | |
tirofiban | glycoprotein IIb/IIIa receptor-antagonist, 16.9% inhibition at 0.042 mM in absence of heparin, 48% inhibition at 0.14 mM in presence of heparin 1 U/ml | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Homo sapiens | - |
thrombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
plasma | - |
Homo sapiens | - |
platelet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | factor Xa is part of the prothrombinase complex with Ca2+, phospholipids and factor Va | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Homo sapiens |
prothrombinase | - |
Homo sapiens |