Literature summary for 3.4.21.6 extracted from

Gould, W.R.; McClanahan, T.B.; Welch, K.M.; Baxi, S.M.; Saiya-Cork, K.; Chi, L.; Johnson, T.R.; Leadley, R.J.
Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro (2006), J. Thromb. Haemost., 4, 834-841.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	inhibitors of blood coagulation factors Xa and IIa, i.e. PD0313052 and argatroban, synergize to reduce thrombus weight and thrombin generation in vivo and in vitro	Homo sapiens
PD0313052	i.e. [(2R, 6S)-2-(5-carbamimidoyl-2-hydroxy-phenyl)-4-[5-(2,6-dimethyl-piperidin-1-yl)-pentyl]-3-oxo-3,4-dihydro-quinoxaline-6-carboxylic acid]	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	PD0313052 and argatroban, inhibitors of blood coagulation factors Xa and IIa, synergize to reduce thrombus weight and thrombin generation in vivo and in vitro	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
plasma	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	PD0313052 and argatroban, inhibitors of blood coagulation factors Xa and IIa, synergize to reduce thrombus weight and thrombin generation in vivo and in vitro	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
factor Xa	-	Homo sapiens
FXa	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000497	-	-	Homo sapiens	PD0313052

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Release 2023.1 (January 2023)