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Literature summary for 3.4.21.6 extracted from

  • Hsu, H.J.; Tsai, K.C.; Sun, Y.K.; Chang, H.J.; Huang, Y.J.; Yu, H.M.; Lin, C.H.; Mao, S.S.; Yang, A.S.
    Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling (2008), J. Biol. Chem., 283, 12343-12353.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.6

Organism

Organism UniProt Comment Textmining
Bos taurus
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Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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 Homo sapiens
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commercial preparation
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 Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information construction of computational molecular models for enzyme-substrate complexes. Binding modes of substrates vary according to the substrate peptide sequence with at least three different substrate-enzyme recognition modes. Three binding modes corresponding to the aryl-binding site accommodating the P4, P3, and P2 side chains, respectively, are likely to account for the specificity of factor Xa toward substrate peptide sequences Homo sapiens ?
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additional information selection of cleavage substrates by substrate phage display and construction of computational molecular models for enzyme-substrate complexes. Binding modes of substrates vary according to the substrate peptide sequence with at least three different substrate-enzyme recognition modes. Three binding modes corresponding to the aryl-binding site accommodating the P4, P3, and P2 side chains, respectively, are likely to account for the specificity of factor Xa toward substrate peptide sequences Bos taurus ?
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