Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Bos taurus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, cooperative binding, required of the intact enzyme and also of its Gla-domain and EGF-like domain to interact with negatively charged phospholipids containing 25% phosphatidylserine and 75% phosphatidylcholine, 3 Ca2+ per binding partner | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the enzyme is processed from factor X to factor Xa | Bos taurus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Bos taurus | thrombin + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the intact enzyme contains a Gla-domain and a N-terminal EGF-like domain, amino acid residues 1-86, as well as a C-terminal EGF-like domain, amino acid residues 154-183 | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
coagulation factor X | - |
Bos taurus |
factor X | - |
Bos taurus |
factor Xa | - |
Bos taurus |
More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | the intact enzyme and also of its Gla-domain and EGF-like domain interact with negatively charged phospholipids containing 25% phosphatidylserine and 75% phosphatidylcholine, kinetics | Bos taurus |