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Literature summary for 3.4.21.6 extracted from

  • Erb, E.M.; Stenflo, J.; Drakenberg, T.
    Interaction of bovine coagulation factor X and its glutamic-acid-containing fragments with phospholipid membranes. A surface plasmon resonance study (2002), Eur. J. Biochem., 269, 3041-3046.
    View publication on PubMed
Search for more literature for 3.4.21.6

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Bos taurus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, cooperative binding, required of the intact enzyme and also of its Gla-domain and EGF-like domain to interact with negatively charged phospholipids containing 25% phosphatidylserine and 75% phosphatidylcholine, 3 Ca2+ per binding partner Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme is processed from factor X to factor Xa Bos taurus

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
 Bos taurus thrombin + ?
-
 ?

Subunits

Subunits Comment Organism
More the intact enzyme contains a Gla-domain and a N-terminal EGF-like domain, amino acid residues 1-86, as well as a C-terminal EGF-like domain, amino acid residues 154-183 Bos taurus

Synonyms

Synonyms Comment Organism
coagulation factor X
-
 Bos taurus
factor X
-
 Bos taurus
factor Xa
-
 Bos taurus
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Bos taurus

Cofactor

Cofactor Comment Organism Structure
additional information the intact enzyme and also of its Gla-domain and EGF-like domain interact with negatively charged phospholipids containing 25% phosphatidylserine and 75% phosphatidylcholine, kinetics Bos taurus