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3.4.21.6: coagulation factor Xa

This is an abbreviated version!
For detailed information about coagulation factor Xa, go to the full flat file.

Word Map on EC 3.4.21.6

Reaction

selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin =

Synonyms

activated blood-coagulation factor X, activated factor X, activated Stuart-Prower factor, autoprothrombin C, blood coagulation factor X, blood coagulation factor Xa, blood-coagulation factor X, activated, clotting factor Xa, coagulation factor X, coagulation factor Xa, f.Xa, factor X, factor Xa, Fgl2 protein, fX, FXa, FXaalpha/beta, hXa, More, oscutarin, plasma thromboplastin, procoagulant factor X, prothrombase, prothrombin activator, prothrombinase, Stuart factor, thrombokinase, thromboplastin, thromboplastin, plasma, trocarin, Trocarin prothrombin activator, VAP, Virus activating protease, Xa

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.6 coagulation factor Xa

Natural Substrates Products

Natural Substrates Products on EC 3.4.21.6 - coagulation factor Xa

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
activated factor VIII + H2O
factor VIII
show the reaction diagram
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proteolytic inactivation
-
-
?
factor VIII + H2O
?
show the reaction diagram
-
factor Xa proteolytically activates Factor VIII by cleaving P1 residues Arg372, Arg740, and Arg1689. Factor Xa also catalyzes inactivating cleavages that occur on a slower time scale than the activating ones
-
-
?
factor VIII + H2O
activated factor VIII + B domain
show the reaction diagram
-
proteolytic activation by removal of the B domain
-
-
?
protease-activated receptor 1 + H2O
activated protease-activated receptor 1 + ?
show the reaction diagram
protease-activated receptor 2 + H2O
activated protease-activated receptor 2 + ?
show the reaction diagram
prothrombin + H2O
?
show the reaction diagram
prothrombin + H2O
thrombin + ?
show the reaction diagram
prothrombin + H2O
thrombin + propeptide of thrombin
show the reaction diagram
prothrombin + H2O
trhombin + ?
show the reaction diagram
additional information
?
-