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Literature summary for 3.4.21.6 extracted from
- Factor Xa (FXa) inhibitor from the nymphs of the camel tick Hyalomma dromedarii (2001), Comp. Biochem. Physiol. B, 130B, 501-512.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| endogeneous polypeptide inhibitor | 8.8fold purification of a 15 kDa polypeptide inhibitor from nymphs of camel tick Hyalomma dromedarii, with potent antocoagulant properties, specific for factor Xa compared to other serine proteases, binds 2 sites of factor Xa, uncompetitive, inhibits blood coagulation, 329 U/mg, complete inhibition by 2 inhibitor units | Camelus bactrianus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Camelus bactrianus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prothrombin + H2O | Camelus bactrianus | - |
thrombin + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Camelus bactrianus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Camelus bactrianus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Camelus bactrianus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-benzoyl-Ile-Glu-Gly-Arg-4-nitroanilide + H2O | - |
Camelus bactrianus | N-benzoyl-Ile-Glu-Gly-Arg + 4-nitroaniline | - |
? | |
| prothrombin + H2O | - |
Camelus bactrianus | thrombin + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor Xa | - |
Camelus bactrianus |
| FXa | - |
Camelus bactrianus |
| More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Camelus bactrianus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Camelus bactrianus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Camelus bactrianus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000134 | - |
endogeneous polypeptide inhibitor | pH 7.4, 25°C, kinetics | Camelus bactrianus |
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