3.4.21.6: coagulation factor Xa

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For detailed information about coagulation factor Xa, go to the full flat file.

Word Map on EC 3.4.21.6

3.4.21.6

anticoagulant

bleeding

platelet

heparin

fibrinogen

thrombosis

pt

venous

antithrombin

thromboembolism

hemorrhage

viii

antithrombotic

fibrin

rivaroxaban

warfarin

hemostatic

embolism

stroke

intravascular

apixaban

d-dimers

coagulopathy

unfractionated

thrombocytopenia

fibrillation

plasminogen

atrial

fibrinolysis

transfusion

hemophilia

thrombus

lupus

chromogenic

willebrand

hypercoagulable

dabigatran

heparin-induced

hematoma

hirudin

haemostasis

antiphospholipid

antiplatelet

thrombin-antithrombin

viper

amidolytic

k-dependent

analysis

rfviia

pharmacology

medicine

thrombophilia

synthesis

fibrinopeptide

drug development

Reaction

selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin =

Synonyms

activated blood-coagulation factor X, activated factor X, activated Stuart-Prower factor, autoprothrombin C, blood coagulation factor X, blood coagulation factor Xa, blood-coagulation factor X, activated, clotting factor Xa, coagulation factor X, coagulation factor Xa, f.Xa, factor X, factor Xa, Fgl2 protein, fX, FXa, FXaalpha/beta, hXa, More, oscutarin, plasma thromboplastin, procoagulant factor X, prothrombase, prothrombin activator, prothrombinase, Stuart factor, thrombokinase, thromboplastin, thromboplastin, plasma, trocarin, Trocarin prothrombin activator, VAP, Virus activating protease, Xa

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.6 coagulation factor Xa

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Results	in table
63	Activating Compound
192	AA Sequence
25	Application
1	CAS Registry Number
10	Cloned(Commentary)
18	Cofactor
12	Crystallization (Commentary)
17523	Disease/ Diagnostics
6	Expression
30	General Information
1	General Stability
125	IC50 Value
1029	Inhibitors
488	Ki Value [mM]
103	KM Value [mM]
50	Localization
33	Metals/Ions
8	Molecular Weight [Da]
94	Natural Substrates/ Products (Substrates)
214	Organism
307	PDB ID
36	pH Optimum
21	Posttranslational Modification
42	Protein Variants
11	Purification (Commentary)
56	Reaction
2	Reaction Type
214	Reference
139	Source Tissue
10	Specific Activity [micromol/min/mg]
1	Storage Stability
267	Substrates and Products (Substrate)
36	Subunits
290	Synonyms
36	Temperature Optimum [°C]
85	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.21.6 - coagulation factor Xa

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114000

Bos taurus

enzyme in presence of 5 mM Ca2+ and 0.4 mM 1,2-dicaproyl-sn-glycero-3-phospho-L-serine, native PAGE

650585

20000

Bos taurus

1 * 20000 + 1 * 30000, two bands detected, SDS-PAGE

81419

30000

Bos taurus

1 * 20000 + 1 * 30000, two bands detected, SDS-PAGE

81419

45000

2 entries

47000

Bos taurus

enzyme in absence of Ca2+ and 1,2-dicaproyl-sn-glycero-3-phospho-L-serine, native PAGE

650585

47000 - 47900

Bos taurus

low speed equilibrium sedimentation, high speed meniscus depletion

81419

65000

Mus musculus

x * 65000, recombinant wild-type enzyme, SDS-PAGE

652682