Literature summary for 3.4.21.6 extracted from

Steen, M.; Tran, S.; Autin, L.; Villoutreix, B.O.; Tholander, A.L.; Dahlbaeck, B.
Mapping of the factor Xa binding site on factor Va by site-directed mutagenesis (2008), J. Biol. Chem., 283, 20805-20812.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Factor V	factor V variants 501A/510A/511D, 501A/510A/511D/513A, 513A/577A/578A, and 501A/510A/511D/513A/577A/578A exhibit markedly reduced factor Xa-cofactor activity tested in the prothrombinase assay, and reduced binding affinity as judged by the direct binding assay.These factor Va variants are normally cleaved at Arg-506 by activated protein C, and the interaction between the factor Xa-factor Va complex and prothrombin is unaffected by the introduced mutations. The key factor Xa binding surface is centered on residues Arg-501, Arg-510, Ala-511, Asp-513, Asp-577, and Asp-578 in the factor Va A2 domain	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Homo sapiens	-

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Release 2023.1 (January 2023)