Protein Variants | Comment | Organism |
---|---|---|
F174A | the mutant has about wild type activity | Homo sapiens |
Y99A | the enzyme shows strongly reduced activity compared to the wild type enzyme | Homo sapiens |
Y99A/F174A | the enzyme shows severely reduced activity compared to the wild type enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
antithrombin | irreversible inhibition | Homo sapiens | |
apixaban | - |
Homo sapiens | |
edoxaban | - |
Homo sapiens | |
recombinant tick saliva anticoagulant protein | - |
Homo sapiens | |
rivaroxaban | - |
Homo sapiens | |
TFPIalpha | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.026 | - |
S-2765 | wild type enzyme, at pH 7.5 and 25°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Homo sapiens | - |
thrombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? | |
S-2765 + H2O | - |
Homo sapiens | Z-D-Arg-Gly-L-Arg + 4-nitroaniline | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 59000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
blood coagulation factor Xa | - |
Homo sapiens |
factor Xa | - |
Homo sapiens |
FXa | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
21 | - |
S-2765 | wild type enzyme, at pH 7.5 and 25°C | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000007 | - |
recombinant tick saliva anticoagulant protein | wild type enzyme, at pH 7.5 and 25°C | Homo sapiens | |
0.00000162 | - |
TFPIalpha | wild type enzyme, at pH 7.5 and 25°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
wild type enzyme, at pH 7.5 and 25°C | Homo sapiens | edoxaban | |
0.000005 | - |
wild type enzyme, at pH 7.5 and 25°C | Homo sapiens | apixaban | |
0.000034 | - |
mutant enzyme Y99A, at pH 7.5 and 25°C | Homo sapiens | apixaban | |
0.000045 | - |
mutant enzyme F174A, at pH 7.5 and 25°C | Homo sapiens | apixaban | |
0.000616 | - |
mutant enzyme Y99A/F174A, at pH 7.5 and 25°C | Homo sapiens | apixaban |