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3.4.21.6: coagulation factor Xa

This is an abbreviated version!
For detailed information about coagulation factor Xa, go to the full flat file.

Word Map on EC 3.4.21.6

Reaction

selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin =

Synonyms

activated blood-coagulation factor X, activated factor X, activated Stuart-Prower factor, autoprothrombin C, blood coagulation factor X, blood coagulation factor Xa, blood-coagulation factor X, activated, clotting factor Xa, coagulation factor X, coagulation factor Xa, f.Xa, factor X, factor Xa, Fgl2 protein, fX, FXa, FXaalpha/beta, hXa, More, oscutarin, plasma thromboplastin, procoagulant factor X, prothrombase, prothrombin activator, prothrombinase, Stuart factor, thrombokinase, thromboplastin, thromboplastin, plasma, trocarin, Trocarin prothrombin activator, VAP, Virus activating protease, Xa

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.6 coagulation factor Xa

KM Value

KM Value on EC 3.4.21.6 - coagulation factor Xa

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0507 - 3.9
Arg-Gly-Arg-4-nitroanilide
0.0867 - 0.0965
benzoyl-Ile-Glu(piperidineamide)-Gly-Arg-p-nitroanilide
0.175 - 0.189
benzoyl-Ile-Glu-(-H/OMe)-Gly-Arg-p-nitroanilide
0.0013
D-cyclohexyl-Gly-L-Pro-L-Arg-4-nitroanilide
-
20 mM Tris-HCl buffer, pH 7.4, containing 100 mM NaCl, 2.5 mM CaCl2 and 0.1% (w/v) PEG 8000 at 25°C
0.0022
D-hexahydrotyrosol-L-Ala-L-Arg-4-nitroanilide
-
20 mM Tris-HCl buffer, pH 7.4, containing 100 mM NaCl, 2.5 mM CaCl2 and 0.1% (w/v) PEG 8000 at 25°C
0.0013
D-phenylalanyl-L-pipecolyl-L-arginine-4-nitroanilide
-
20 mM Tris-HCl buffer, pH 7.4, containing 100 mM NaCl, 2.5 mM CaCl2 and 0.1% (w/v) PEG 8000 at 25°C
0.00016
FPR-prothrombin
-
pH 7.7, 37°C, in presence of phospholipid at 0.025 mM
-
0.00058 - 0.00078
fragment 1.2:prethrombin-2
-
0.036 - 0.24
L-Arg-Gly-L-Arg-4-nitroanilide
0.00065 - 0.00095
meizothrombin
-
0.061
methoxycarbonyl-D-cyclohexylglycyl-Gly-L-Arg-4-nitroanilide
-
20 mM Tris-HCl buffer, pH 7.4, containing 100 mM NaCl, 2.5 mM CaCl2 and 0.1% (w/v) PEG 8000 at 25°C
0.072 - 1.38
methoxycarbonylcyclohexyl-Gly-Gly-L-Arg-4-nitroanilide
0.042 - 0.122
N-alpha-benzyloxycarbonyl-D-arginyl-glycyl-L-arginine-4-nitroanilide
0.0045
N6-CBZ-D-Lys-L-Pro-L-Arg-4-nitroanilide
-
20 mM Tris-HCl buffer, pH 7.4, containing 100 mM NaCl, 2.5 mM CaCl2 and 0.1% (w/v) PEG 8000 at 25°C
0.0377
Nalpha-benzyloxycarbonyl-L-Lys-p-nitrophenyl ester
-
-
0.0052 - 0.0069
prethrombin-1
-
0.0088
prethrombin-2
-
prothrombinase complex, pH 7.4, 22°C
-
0.000018 - 0.0083
prothrombin
-
0.000071
ProTS195A
-
pH 7.7, 37°C, versus prothrombin, in absence of phospholipid
-
0.00036 - 0.00045
recombinant prothrombin R155A/R284A/R271A mutant rMZ-II
-
0.00039 - 0.0005
recombinant prothrombin R155A/R284A/R320A mutant rP2-II
-
0.026
S-2765
-
wild type enzyme, at pH 7.5 and 25°C
0.133 - 0.739
S2222
0.052 - 0.112
S2765
0.097 - 0.206
tosyl-glycyl-prolyl-D-arginine-4-nitroanilide
additional information
additional information
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