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Literature summary for 3.4.21.6 extracted from

  • Bradford, H.N.; Micucci, J.A.; Krishnaswamy, S.
    Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate (2010), J. Biol. Chem., 285, 328-338.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.6

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics with wild-type and mutant prothrombin substrates, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Homo sapiens cleavage at Arg320 followed by cleavage at Arg271 thrombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O cleavage at Arg320 followed by cleavage at Arg271 Homo sapiens thrombin + ?
-
 ?
prothrombin + H2O cleavage at Arg320 followed by cleavage at Arg271. Enzyme activity and active site docking with wild-type prothrombin and cleavage site variants, in which the cleavage sequence Asp-Gly-Arg is replaced e.g. by Arg-Gly-Arg or Arg-Arg, overview. Product identification, overview Homo sapiens thrombin + ?
-
 ?
S2238 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
prothrombinase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
96
-
 prothrombin wild-type substrate, for cleavage at Arg320 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Homo sapiens