1.1.1.2: alcohol dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about alcohol dehydrogenase (NADP+), go to the full flat file.

Reaction

a primary alcohol
+
NADP+
=
an aldehyde
+
NADPH
+
H+

Synonyms

2° Adh, 3-DG-reducing enzyme, AAur_2040, ADH, ADH-1, ADH-2, ADH-I, ADH-II, ADH2, Adh319, ADH4, Adh6, AdhA, AdhB, AKR1A1, AKR1A4, alcohol dehydrogenase C, alcohol dehydrogenase [NADP(+)], Alcohol dehydrogenase [NADP+], aldehyde reductase, aldehyde reductase (NADPH2), aldehyde/ketone reductase, aldo-keto reductase, Aldo-keto reductase family 1 member A1, aldose reductase, ALDR, alipathic aldehyde reductase, ALR, ALR 1, ALR1, BdhA, bovine brain aldehyde reductase, D-glucuronate reductase, daunorubicin reductase, DRD, EhADH1, Gre2p, hexogenate dehydrogenase, high-Km aldehyde reductase, HvADH2, L-hexonate dehydrogenase, LB-RADH, LBADH, liver alcohol dehydrogenase, low-Km aldehyde reductase, mevaldate reductase, Mpd1, NADP(H)-dependent alcohol dehydrogenase, NADP-alcohol dehydrogenase, NADP-aldehyde reductase, NADP-dependent aldehyde reductase, NADP-linked aryl alcohol dehydrogenase, NADPH-aldehyde reductase, NADPH-cytochrome c reductase, NADPH-dependent aldehyde reductase, NADPH-dependent FALDR, NADPH-dependent fatty aldehyde reductase, NADPH-linked aldehyde reductase, nonspecific succinic semialdehyde reductase, Octopine dehydrogenase, putative iron alcohol dehydrogenase, PyAeADHII, rabbit kidney aldehyde-ketone reductase, RADH, ScADHVI, short-chain ADH, short-chain alcohol dehydrogenase, short-chain dehydrogenase/reductase, TBADH, TbADH1, Teth39_1597, Teth514_0564, TPN-L-hexonate dehydrogenase, TPNH-linked aldehyde reductase, TPNH-specific aldehyde reductase, triphosphopyridine nucleotide-linked aldehyde reductase, TsAdh319, Y63 protein, yeast alcohol dehydrogenase, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.2 alcohol dehydrogenase (NADP+)

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.2 - alcohol dehydrogenase (NADP+)

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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(4-hydroxy-3-[3-methyl-3-butene-1-ynyl]benzaldehyde) + NADPH + H+
(4-hydroxy-3-[3-methyl-3-butene-1-ynyl]benzyl alcohol) + NADP+
show the reaction diagram
-
eutypine, a toxin produced by Eutypa lata, the causal agent of Eutypa dieback in the grapevine Vitis vinifera
eutypinol, non-toxic metabolite
ir
2-propanol + NADP+
acetone + NADPH
show the reaction diagram
Ac-D-Leu-L-Trp-D-Leu-L-Trp-Gly-S-CoA + NADPH + H+
?
show the reaction diagram
-
-
-
-
-
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
-
the proposed physiological role of NADP-dependent alcohol dehydrogenase in Pyrococcus furiosus is to both dispose of excess reducing equivalents and to detoxify the aldehydes produced by the fermentative pathways
-
-
?
aldehyde + NADPH + H+
alcohol + NADP+
show the reaction diagram
-
the physiological role of this enzyme is likely to catalyze the reduction of aldehydes to alcohols
-
-
?
alpha-diketone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
D-glucose + NADPH + H+
sorbitol + NADP+
show the reaction diagram
D-glucuronate + NADPH
L-gulonate + NADP+
show the reaction diagram
D-glucuronate + NADPH + H+
? + NADP+
show the reaction diagram
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
show the reaction diagram
DL-glyceraldehyde + NADPH + H+
DL-glycerol + NADP+
show the reaction diagram
-
-
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
show the reaction diagram
-
-
-
-
r
ethylacetoacetate + NADPH
ethyl L-(+)-3-hydroxybutyrate + NADP+
show the reaction diagram
glucuronate + NADPH
?
show the reaction diagram
glucuronate + NADPH + H+
?
show the reaction diagram
L-glyceraldehyde + NADPH
glycerol + NADP+
show the reaction diagram
L-gulonic acid + NADP+
D-glucuronic acid + NADPH
show the reaction diagram
lauryl aldehyde + NADPH
lauryl alcohol + NADP+
show the reaction diagram
-
isozyme AR3
-
-
?
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
show the reaction diagram
additional information
?
-
-
YqhD mediates resistance to potassium tellurite and other reactive oxygen species elicitors in Escherichia coli, and protects from protein oxidation, YqhD lowers toxic acrolein concentrations, overview
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