1.1.1.2: alcohol dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about alcohol dehydrogenase (NADP+), go to the full flat file.

Reaction

a primary alcohol
+
NADP+
=
an aldehyde
+
NADPH
+
H+

Synonyms

2° Adh, 3-DG-reducing enzyme, AAur_2040, ADH, ADH-1, ADH-2, ADH-I, ADH-II, ADH2, Adh319, ADH4, Adh6, AdhA, AdhB, AKR1A1, AKR1A4, alcohol dehydrogenase C, alcohol dehydrogenase [NADP(+)], Alcohol dehydrogenase [NADP+], aldehyde reductase, aldehyde reductase (NADPH2), aldehyde/ketone reductase, aldo-keto reductase, Aldo-keto reductase family 1 member A1, aldose reductase, ALDR, alipathic aldehyde reductase, ALR, ALR 1, ALR1, BdhA, bovine brain aldehyde reductase, D-glucuronate reductase, daunorubicin reductase, DRD, EhADH1, Gre2p, hexogenate dehydrogenase, high-Km aldehyde reductase, HvADH2, L-hexonate dehydrogenase, LB-RADH, LBADH, liver alcohol dehydrogenase, low-Km aldehyde reductase, mevaldate reductase, Mpd1, NADP(H)-dependent alcohol dehydrogenase, NADP-alcohol dehydrogenase, NADP-aldehyde reductase, NADP-dependent aldehyde reductase, NADP-linked aryl alcohol dehydrogenase, NADPH-aldehyde reductase, NADPH-cytochrome c reductase, NADPH-dependent aldehyde reductase, NADPH-dependent FALDR, NADPH-dependent fatty aldehyde reductase, NADPH-linked aldehyde reductase, nonspecific succinic semialdehyde reductase, Octopine dehydrogenase, putative iron alcohol dehydrogenase, PyAeADHII, rabbit kidney aldehyde-ketone reductase, RADH, ScADHVI, short-chain ADH, short-chain alcohol dehydrogenase, short-chain dehydrogenase/reductase, TBADH, TbADH1, Teth39_1597, Teth514_0564, TPN-L-hexonate dehydrogenase, TPNH-linked aldehyde reductase, TPNH-specific aldehyde reductase, triphosphopyridine nucleotide-linked aldehyde reductase, TsAdh319, Y63 protein, yeast alcohol dehydrogenase, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.2 alcohol dehydrogenase (NADP+)

Turnover Number

Turnover Number on EC 1.1.1.2 - alcohol dehydrogenase (NADP+)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5.6
(+)-Camphorquinone
Sus scrofa
-
-
740
(2R,3R)-2,3-butanediol
Thermococcus guaymasensis
F8S123
cosubstrate: NADP+, pH 7.5, 80°C
512
(2S,3S)-2,3-butanediol
Thermococcus guaymasensis
F8S123
cosubstrate: NADP+, pH 7.5, 80°C
0.008 - 1.4
(R)-1-phenyl-2-propanol
-
0.65 - 38.6
(S)-1-phenyl-2-propanol
5.31
1,5-pentanediol
Mycobacterium sp.
A0A125SUY5
pH 7.0. 30°C
918
1-Pentanol
Saccharomyces cerevisiae
-
pH 10.0, 25°C
833
2-butanol
Thermococcus guaymasensis
F8S123
cosubstrate: NADP+, pH 7.5, 80°C
190
2-butanone
Thermococcus guaymasensis
F8S123
cosubstrate: NADPH, pH 7.5, 80°C
0.53
2-propanol
Thermococcus sibiricus
-
pH 10.5, 60°C
7.84
3-methyl-1,5-pentanediol
Mycobacterium sp.
A0A125SUY5
pH 7.0. 30°C
-
173 - 2866
3-methyl-1-butanol
296 - 9581
3-Methylbutanal
26.8
3-Pyridinecarboxaldehyde
Sus scrofa
-
-
0.07
3-Pyridinemethanol
Sus scrofa
-
-
21.7
4-carboxybenzaldehyde
Sus scrofa
-
-
16.6
4-Cyanobenzaldehyde
Sus scrofa
-
-
0.148
4-Hydroxy-3-methoxybenzyl alcohol
Homo sapiens
-
-
22
4-Nitrobenzaldehyde
Sus scrofa
-
-
19.3
4-Pyridinecarboxaldehyde
Sus scrofa
-
-
5.5 - 157.6
acetaldehyde
142
acetoin
Thermococcus guaymasensis
F8S123
cosubstrate: NADPH, pH 7.5, 80°C
35.7 - 44.5
acetophenone
62.5
acrolein
Escherichia coli
-
pH 7.0, 37°C
0.0733
benzylalcohol
Homo sapiens
-
-
7.02
butan-1-ol
Mycobacterium sp.
A0A125SUY5
pH 7.0. 30°C
20.1 - 156.6
Butanal
59.5
butanaldehyde
Escherichia coli
-
pH 7.0, 37°C
17.05 - 48
butanol
48
Butyraldehyde
Pseudothermotoga hypogea
-
pH 8.0, 80°C
107.9 - 7913
cinnamaldehyde
14.8 - 3404
cinnamyl alcohol
11.6
D-glucuronate
Sus scrofa
-
-
14.4
D-glyceraldehyde
Sus scrofa
-
-
13.7
D-Lactaldehyde
Sus scrofa
-
-
0.7
D-xylose
Thermococcus sibiricus
-
pH 10.5, 60°C
202
diacetyl
Thermococcus guaymasensis
F8S123
cosubstrate: NADPH, pH 7.5, 80°C
14 - 84
ethanol
0.0283 - 0.612
glycerol
359
Hexanal
Saccharomyces cerevisiae
-
pH 7.0, 25°C
10.7
Hexanol
Saccharomyces cerevisiae
-
pH 7.0, 25°C
1.77
L-arabitol
Sus scrofa
-
-
60.1
malondialdehyde
Escherichia coli
-
pH 7.0, 37°C
952
meso-2,3-butanediol
Thermococcus guaymasensis
F8S123
cosubstrate: NADP+, pH 7.5, 80°C
3.7
methylglyoxal
Pyrococcus furiosus
-
80°C, pH not specified in the publication
2.4 - 9.9
NAD+
2.7 - 36.6
NADH
0.45 - 1333
NADP+
1.51 - 158
NADPH
9.5
p-nitrobenzaldehyde
Homo sapiens
-
-
49.2 - 11920
pentanal
13.15
Pentanol
Synechocystis sp.
-
; in 30 mM Tris-HCl (pH 8.0)
10.4
phenylacetaldehyde
Pyrococcus furiosus
-
80°C, pH not specified in the publication
0.08
phenylethanediol
Homo sapiens
-
-
0.0283 - 1132
Phenylethanol
0.0433
Propane-1,2-diol
Homo sapiens
-
-
45.1
propionaldehyde
Escherichia coli
-
pH 7.0, 37°C
2.04
Pyruvaldehyde
Thermococcus sibiricus
-
pH 7.5, 60°C
263 - 6000
veratraldehyde