1.1.1.2: alcohol dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about alcohol dehydrogenase (NADP+), go to the full flat file.

Reaction

a primary alcohol
+
NADP+
=
an aldehyde
+
NADPH
+
H+

Synonyms

2° Adh, 3-DG-reducing enzyme, AAur_2040, ADH, ADH-1, ADH-2, ADH-I, ADH-II, ADH2, Adh319, ADH4, Adh6, AdhA, AdhB, AKR1A1, AKR1A4, alcohol dehydrogenase C, alcohol dehydrogenase [NADP(+)], Alcohol dehydrogenase [NADP+], aldehyde reductase, aldehyde reductase (NADPH2), aldehyde/ketone reductase, aldo-keto reductase, Aldo-keto reductase family 1 member A1, aldose reductase, ALDR, alipathic aldehyde reductase, ALR, ALR 1, ALR1, BdhA, bovine brain aldehyde reductase, D-glucuronate reductase, daunorubicin reductase, DRD, EhADH1, Gre2p, hexogenate dehydrogenase, high-Km aldehyde reductase, HvADH2, L-hexonate dehydrogenase, LB-RADH, LBADH, liver alcohol dehydrogenase, low-Km aldehyde reductase, mevaldate reductase, Mpd1, NADP(H)-dependent alcohol dehydrogenase, NADP-alcohol dehydrogenase, NADP-aldehyde reductase, NADP-dependent aldehyde reductase, NADP-linked aryl alcohol dehydrogenase, NADPH-aldehyde reductase, NADPH-cytochrome c reductase, NADPH-dependent aldehyde reductase, NADPH-dependent FALDR, NADPH-dependent fatty aldehyde reductase, NADPH-linked aldehyde reductase, nonspecific succinic semialdehyde reductase, Octopine dehydrogenase, putative iron alcohol dehydrogenase, PyAeADHII, rabbit kidney aldehyde-ketone reductase, RADH, ScADHVI, short-chain ADH, short-chain alcohol dehydrogenase, short-chain dehydrogenase/reductase, TBADH, TbADH1, Teth39_1597, Teth514_0564, TPN-L-hexonate dehydrogenase, TPNH-linked aldehyde reductase, TPNH-specific aldehyde reductase, triphosphopyridine nucleotide-linked aldehyde reductase, TsAdh319, Y63 protein, yeast alcohol dehydrogenase, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.2 alcohol dehydrogenase (NADP+)

KM Value

KM Value on EC 1.1.1.2 - alcohol dehydrogenase (NADP+)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.33
(+)-Camphorquinone
-
-
15
(2E,4E)-hexa-2,4-dienal
-
pH 7.4, 25°C, with NAD(P)H
15.2
(2R,3R)-2,3-butanediol
cosubstrate: NADP+, pH 7.5, 80°C
246
(2S,3S)-2,3-butanediol
cosubstrate: NADP+, pH 7.5, 80°C
5.4 - 327.6
(2S,5S)-hexanediol
0.0063
(4-hydroxy-3-[3-methyl-3-butene-1-ynyl]benzaldehyde)
-
eutypine
0.112
(S)-1-phenylethanol
-
-
0.46 - 0.8
1,2-Cyclohexanedione
23.38
1,5-pentanediol
pH 7.0. 30°C
0.00246
1-Heptanol
-
-
0.015
1-hexanal
-
-
0.00251 - 6.79
1-Hexanol
0.00273 - 0.99
1-Pentanol
2.9 - 55.5
1-phenylethanol
0.00522
1-propanol
-
-
0.015
13-cis-retinal
-
-
56.4 - 79
2,5-hexanedione
0.38 - 170
2-butanol
0.31
2-butanone
cosubstrate: NADPH, pH 7.5, 80°C
2
2-chloroheptanal
-
-
0.049 - 4.8
2-Methoxybenzaldehyde
1.85 - 17.7
2-methylbutanal
30.3 - 60.8
2-Pentanol
0.05
2-phenylacetaldehyde
Thermococcus paravinellae
-
pH 8.0, 80°C
15
2-phenylethanol
Thermococcus paravinellae
-
pH 8.0, 80°C
0.408 - 168
2-propanol
6.1
3,4-dihydroxyphenylacetaldehyde
-
-
12
3,4-dihydroxyphenylglycolaldehyde
-
-
0.0054
3-Fluorobenzaldehyde
-
-
10.27
3-methyl-1,5-pentanediol
pH 7.0. 30°C
-
1.61 - 4.6
3-methyl-1-butanol
0.048 - 1.89
3-Methylbutanal
0.008 - 8.61
3-Pyridinecarboxaldehyde
5.5
3-Pyridinemethanol
-
-
1.6
4-Carboxyacetophenone
-
-
0.1
4-Carboxyphenylglyoxal
-
-
21.8
4-hydroxybenzaldehyde
-
pH 6.5, 30°C
24.1
4-methoxybenzaldehyde
-
pH 6.5, 30°C
0.0053
4-Nitrobenzaldehyde
-
-
0.0045
4-pyridine carboxaldehyde
-
-
0.062 - 1.2
4-Pyridinecarboxaldehyde
27
5-Hydroxyindoleacetaldehyde
-
-
0.11 - 4
5alpha-dihydrotestosterone
0.009
9-cis-retinal
-
-
0.019
9-cis-retinol
-
-
0.12 - 210
acetaldehyde
0.32
acetoin
cosubstrate: NADPH, pH 7.5, 80°C
0.7 - 1.091
acetone
0.034 - 10.9
acetophenone
0.5
acetylCoA
-
2° Adh
4.81
acrolein
-
pH 7.0, 37°C
0.008
all-trans-retinal
-
-
0.02
all-trans-retinol
-
-
0.099 - 13
androstane-3,17-dione
2.5
Benzalacetone
-
-
0.01 - 9.09
benzaldehyde
1.43 - 2
benzyl alcohol
10 - 43.75
butan-1-ol
0.31 - 0.51
butan-2-ol
0.11 - 23.1
Butanal
0.67
butanaldehyde
-
pH 7.0, 37°C
14
butane 2,3-dione
-
-
1.4 - 8.2
butanol
0.12 - 0.24
Butanone
0.083 - 7.69
Butyraldehyde
1.4
Camphorquinone
-
-
29
Chloral hydrate
-
-
0.017 - 0.172
cinnamaldehyde
0.08 - 0.7
cinnamyl alcohol
0.177
cis-11-hexadecenal
-
-
0.06
coniferylaldehyde
-
-
1.18 - 36.77
cyclohexanone
8.45 - 19.33
Cyclopentanol
543
D-galactose
-
aldehyde reductase II
1.1
D-galacturonate
-
AR1
215
D-glucose
-
AR I
1.5 - 364
D-glucuronate
1.29 - 2.99
D-glucuronic acid
19.6 - 67
D-glucuronolactone
0.43 - 8.2
D-glyceraldehyde
54.4 - 2080
D-xylose
0.08
daunorubicin
-
reductase I
0.0033
decanal
-
-
0.21 - 10.8
diacetyl
1.3 - 76
DL-glyceraldehyde
0.013 - 600
ethanol
0.091
ethyl 4-bromo-3-oxobutanoate
-
-
0.36
ethyl 4-chloro-3-oxobutanoate
-
-
24 - 25
ethyl acetoacetate
2.7 - 26
ethylacetoacetate
1.6
formaldehyde
-
1° Adh
0.207
furaldehyde
-
-
2.5 - 2.53
glucuronate
0.07 - 7.59
glyceraldehyde
775
glycerol
-
-
9.9
glycolaldehyde
-
AR2
0.27 - 10
Heptanal
0.03
hexadecanal
-
-
0.04 - 5.5
Hexanal
0.35 - 9.1
Hexanol
0.0038
hydroxyindol-3-ylacetaldehyde
-
low-Km reductase
0.0059 - 0.2
indol-3-ylacetaldehyde
0.6
indolacetaldehyde
-
-
0.32 - 3.7
Indole-3-acetaldehyde
1360
L-arabitol
-
-
4.9 - 11.1
L-Glyceraldehyde
0.31
laurylaldehyde
-
AR2
0.007
m-chlorobenzaldehyde
-
-
0.027 - 0.212
m-methoxybenzaldehyde
0.02
m-methylbenzaldehyde
-
-
0.002 - 4.4
m-nitrobenzaldehyde
1.78
malondialdehyde
-
pH 7.0, 37°C
0.009 - 0.03
menadione
19.3
meso-2,3-butanediol
cosubstrate: NADP+, pH 7.5, 80°C
1.2
methyl 4-bromo-3-oxobutanoate
-
mutant L54Q, pH 6.5, 30°C; wild-type, pH 6.5, 30°C
0.2 - 3.2
methylglyoxal
0.0033 - 47.1
n-butanol
1.1 - 150
n-Butyraldehyde
0.07
n-decanal
-
-
0.019 - 0.02
n-dodecanal
0.008
n-hexadecanal
-
-
0.004
n-octadecanal
-
-
0.77
n-octanal
-
-
12 - 100
n-Propanol
0.014
n-tetradecanal
-
-
0.06 - 20
NAD+
0.025 - 23.84
NADH
0.007 - 46.7
NADP+
0.001 - 4.11
NADPH
0.702
o-fluorobenzaldehyde
-
-
0.125
o-methylbenzaldehyde
-
-
0.376 - 4.6
o-nitrobenzaldehyde
0.01 - 0.21
octanal
0.09 - 0.15
Octanol
0.1
octyl 4-chloro-3-oxobutanoate
-
-
0.004 - 4
p-Carboxybenzaldehyde
0.94 - 6.7
p-chlorobenzaldehyde
0.005 - 0.51
p-cyanobenzaldehyde
0.04
p-fluorobenzaldehyde
-
-
0.0023 - 0.91
p-hydroxyphenylacetaldehyde
0.0007 - 0.65
p-hydroxyphenylglycolaldehyde
0.141 - 0.15
p-Methoxybenzaldehyde
0.041
p-methylbenzaldehyde
-
-
1.4 - 10
p-nitroacetophenone
0.0013 - 5.9
p-nitrobenzaldehyde
0.02
p-tolualdehyde
-
-
0.049 - 3.01
pentanal
0.22 - 1.54
Pentanol
0.091
phenylacetaldehyde
-
80°C, pH not specified in the publication
2.2
Phenylethanol
-
pH 10.0, 25°C
0.11 - 1.6
Phenylglyoxal
0.56 - 16.4
propan-2-ol
27 - 38.9
propanal
0.16
propanone
-
2° Adh
0.008 - 14.54
propionaldehyde
0.042 - 3
pyridine 3-aldehyde
4 - 5.2
pyridine 4-aldehyde
1.2 - 17.75
Pyruvaldehyde
111
ribose
-
AR2
0.066 - 6.9
Salicylaldehyde
0.126
sinapylaldehyde
-
-
2.95
sodium D-glucuronate
-
aldehyde reductase II
0.028 - 18
Succinic semialdehyde
0.06 - 27.1
trans-2-hexenal
0.22 - 1.69
trans-2-hexenol
0.058 - 0.073
veratraldehyde
41 - 160
xylose