1.1.1.2: alcohol dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about alcohol dehydrogenase (NADP+), go to the full flat file.

Reaction

a primary alcohol
+
NADP+
=
an aldehyde
+
NADPH
+
H+

Synonyms

2 Adh, 3-DG-reducing enzyme, AAur_2040, ADH, ADH-1, ADH-2, ADH-I, ADH-II, ADH2, Adh319, ADH4, Adh6, AdhA, AdhB, AKR1A1, AKR1A4, alcohol dehydrogenase C, alcohol dehydrogenase [NADP(+)], Alcohol dehydrogenase [NADP+], aldehyde reductase, aldehyde reductase (NADPH2), aldehyde/ketone reductase, aldo-keto reductase, Aldo-keto reductase family 1 member A1, aldose reductase, ALDR, alipathic aldehyde reductase, ALR, ALR 1, ALR1, BdhA, bovine brain aldehyde reductase, D-glucuronate reductase, daunorubicin reductase, DRD, EhADH1, Gre2p, hexogenate dehydrogenase, high-Km aldehyde reductase, HvADH2, L-hexonate dehydrogenase, LB-RADH, LBADH, liver alcohol dehydrogenase, low-Km aldehyde reductase, mevaldate reductase, Mpd1, NADP(H)-dependent alcohol dehydrogenase, NADP-alcohol dehydrogenase, NADP-aldehyde reductase, NADP-dependent aldehyde reductase, NADP-linked aryl alcohol dehydrogenase, NADPH-aldehyde reductase, NADPH-cytochrome c reductase, NADPH-dependent aldehyde reductase, NADPH-dependent FALDR, NADPH-dependent fatty aldehyde reductase, NADPH-linked aldehyde reductase, nonspecific succinic semialdehyde reductase, Octopine dehydrogenase, putative iron alcohol dehydrogenase, PyAeADHII, rabbit kidney aldehyde-ketone reductase, RADH, ScADHVI, short-chain ADH, short-chain alcohol dehydrogenase, short-chain dehydrogenase/reductase, TBADH, TbADH1, Teth39_1597, Teth514_0564, TPN-L-hexonate dehydrogenase, TPNH-linked aldehyde reductase, TPNH-specific aldehyde reductase, triphosphopyridine nucleotide-linked aldehyde reductase, TsAdh319, Y63 protein, yeast alcohol dehydrogenase, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.2 alcohol dehydrogenase (NADP+)

KCat KM Value

KCat KM Value on EC 1.1.1.2 - alcohol dehydrogenase (NADP+)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
49
(2R,3R)-2,3-butanediol
Thermococcus guaymasensis
F8S123
cosubstrate: NADP+, pH 7.5, 80C
16548
2.08
(2S,3S)-2,3-butanediol
Thermococcus guaymasensis
F8S123
cosubstrate: NADP+, pH 7.5, 80C
10334
0.0069 - 0.639
(R)-1-phenyl-2-propanol
210629
0.551 - 45.3
(S)-1-phenyl-2-propanol
57435
230
1,5-pentanediol
Mycobacterium sp.
A0A125SUY5
pH 7.0. 30C
21054
2192
2-butanol
Thermococcus guaymasensis
F8S123
cosubstrate: NADP+, pH 7.5, 80C
1132
613
2-butanone
Thermococcus guaymasensis
F8S123
cosubstrate: NADPH, pH 7.5, 80C
1171
0.3
2-Pentanol
Pyrococcus furiosus
O73949
pH 10.0, 70C
2329
300
2-phenylacetaldehyde
Thermococcus paravinellae
-
pH 8.0, 80C
17670
2.1
2-phenylethanol
Thermococcus paravinellae
-
pH 8.0, 80C
1667
716
3,4-dihydro-1(2H)-naphthalenone
Pyrobaculum aerophilum
-
95C, pH 7.5
51336
760
3-methyl-1,5-pentanediol
Mycobacterium sp.
A0A125SUY5
pH 7.0. 30C
213984
0.0028 - 76.4
acetaldehyde
90
444
acetoin
Thermococcus guaymasensis
F8S123
cosubstrate: NADPH, pH 7.5, 80C
1274
160
butan-1-ol
Mycobacterium sp.
A0A125SUY5
pH 7.0. 30C
2646
3
Butanal
Pectobacterium atrosepticum
U6CL97
pH 7.0, temperature not specified in the publication
540
962
diacetyl
Thermococcus guaymasensis
F8S123
cosubstrate: NADPH, pH 7.5, 80C
746
0.65 - 6
ethanol
69
49
meso-2,3-butanediol
Thermococcus guaymasensis
F8S123
cosubstrate: NADP+, pH 7.5, 80C
4067
1160 - 1420
methyl 4-bromo-3-oxobutanoate
133544
18.5
methylglyoxal
Pyrococcus furiosus
-
80C, pH not specified in the publication
322
0.12
NAD+
Pyrococcus furiosus
-
80C, pH not specified in the publication
7
0.13 - 0.26
NADH
8
223 - 3333
NADP+
10
0.54 - 14360
NADPH
5
123.1
pentanal
Pectobacterium atrosepticum
U6CL97
pH 7.0, temperature not specified in the publication
781
114
phenylacetaldehyde
Pyrococcus furiosus
-
80C, pH not specified in the publication
769
4.2
Pyruvaldehyde
Pyrococcus furiosus
O73949
pH 7.0, 70C
5610