1.1.1.2: alcohol dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about alcohol dehydrogenase (NADP+), go to the full flat file.

Reaction

a primary alcohol
+
NADP+
=
an aldehyde
+
NADPH
+
H+

Synonyms

2 Adh, 3-DG-reducing enzyme, AAur_2040, ADH, ADH-1, ADH-2, ADH-I, ADH-II, ADH2, Adh319, ADH4, Adh6, AdhA, AdhB, AKR1A1, AKR1A4, alcohol dehydrogenase C, alcohol dehydrogenase [NADP(+)], Alcohol dehydrogenase [NADP+], aldehyde reductase, aldehyde reductase (NADPH2), aldehyde/ketone reductase, aldo-keto reductase, Aldo-keto reductase family 1 member A1, aldose reductase, ALDR, alipathic aldehyde reductase, ALR, ALR 1, ALR1, BdhA, bovine brain aldehyde reductase, D-glucuronate reductase, daunorubicin reductase, DRD, EhADH1, Gre2p, hexogenate dehydrogenase, high-Km aldehyde reductase, HvADH2, L-hexonate dehydrogenase, LB-RADH, LBADH, liver alcohol dehydrogenase, low-Km aldehyde reductase, mevaldate reductase, Mpd1, NADP(H)-dependent alcohol dehydrogenase, NADP-alcohol dehydrogenase, NADP-aldehyde reductase, NADP-dependent aldehyde reductase, NADP-linked aryl alcohol dehydrogenase, NADPH-aldehyde reductase, NADPH-cytochrome c reductase, NADPH-dependent aldehyde reductase, NADPH-dependent FALDR, NADPH-dependent fatty aldehyde reductase, NADPH-linked aldehyde reductase, nonspecific succinic semialdehyde reductase, Octopine dehydrogenase, putative iron alcohol dehydrogenase, PyAeADHII, rabbit kidney aldehyde-ketone reductase, RADH, ScADHVI, short-chain ADH, short-chain alcohol dehydrogenase, short-chain dehydrogenase/reductase, TBADH, TbADH1, Teth39_1597, Teth514_0564, TPN-L-hexonate dehydrogenase, TPNH-linked aldehyde reductase, TPNH-specific aldehyde reductase, triphosphopyridine nucleotide-linked aldehyde reductase, TsAdh319, Y63 protein, yeast alcohol dehydrogenase, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.2 alcohol dehydrogenase (NADP+)

IC50 Value

IC50 Value on EC 1.1.1.2 - alcohol dehydrogenase (NADP+)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0802
(1H-indol-1-yl)acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0048
(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0406
(3-sulfanyl-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0012
(3-[[(2-fluorophenyl)methyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0235
(3-[[2-oxo-2-(2,4,6-trimethylanilino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.049
(4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indol-5-yl)acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0248
(6H-indolo[2,3-b]quinoxalin-6-yl)acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0151
(7H-indolo[2',3':5,6][1,2,4]triazino[2,3-a]benzimidazol-7-yl)acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0196
(8-methyl-3-[[2-oxo-2-(propylamino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.000143
2-(2-oxo-3-phenethylquinoxalin-1(2H)-yl) acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.00082
2-(2-oxo-3-styrylquinoxalin-1(2H)-yl) acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.000283
2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl) acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.00186
2-(3-(3-(tert-butylamino)-3-oxoprop-1-en-1-yl)-2-oxoquinoxalin-1(2H)-yl) acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.00753
2-(3-(4-(4-methoxyphenyl) piperazin-1-yl)-2-oxoquinoxalin-1(2H)-yl) acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.00114
2-(3-(4-fluorophenethyl)-2-oxoquinoxalin-1(2H)-yl) acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.00143
2-(3-(4-fluorostyryl)-2-oxoquinoxalin-1(2H)-yl) acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.000362
2-(3-(4-fluorostyryl)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.00066
2-(6-chloro-3-(4-fluorostyryl)-2-oxoquinoxalin-1(2H)-yl)acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.00388
2-(7-chloro-2-oxo-3-styrylquinoxalin-1(2H)-yl) acetic acid
Rattus norvegicus
-
pH 7.2, 37C, ALR1
-
0.000044
20alpha-hydroxysteroid dehydrogenase
Sus scrofa
-
-
-
0.011
3,5-dichlorosalicylic acid
Sus scrofa
-
-
0.0118
3-(1H-indol-1-yl)propanoic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0067
3-[3-[(diethylamino)methyl]-1H-indol-1-yl]propanoic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0684
[3-(2,2-dimethylpropanoyl)-1H-indol-1-yl]acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0381
[3-[(diethylamino)methyl]-1H-indol-1-yl]acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0223
[3-[(dimethylamino)methyl]-2-methyl-1H-indol-1-yl]acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0325
[3-[(morpholin-4-yl)methyl]-1H-indol-1-yl]acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0141
[3-[(propan-2-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl]acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0192
[3-[(pyrrolidin-1-yl)methyl]-1H-indol-1-yl]acetic acid
Rattus norvegicus
P07943
pH and temperature not specified in the publication
0.0054
[5-(3-carboxymethoxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
Sus scrofa
-
25C, pH 6.7; ALR1, pH not specified in the publication, temperature not specified in the publication
0.037
[5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid
Sus scrofa
-
25C, pH 6.7; ALR1, pH not specified in the publication, temperature not specified in the publication