1.1.1.2: alcohol dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about alcohol dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

2� Adh, 3-DG-reducing enzyme, A3L14_07690, AAur_2040, ADH, ADH-1, ADH-2, ADH-I, ADH-II, ADH2, Adh319, ADH4, Adh6, AdhA, AdhB, AdhD, AKR1A1, AKR1A4, alcohol dehydrogenase C, alcohol dehydrogenase D, alcohol dehydrogenase [NADP(+)], Alcohol dehydrogenase [NADP+], aldehyde reductase, aldehyde reductase (NADPH2), aldehyde/ketone reductase, aldo-keto reductase, Aldo-keto reductase family 1 member A1, aldose reductase, ALDR, alipathic aldehyde reductase, ALR, ALR 1, ALR1, BdhA, bovine brain aldehyde reductase, CbADH, D-glucuronate reductase, daunorubicin reductase, DRD, EhADH1, FeADH, Gre2p, hexogenate dehydrogenase, high-Km aldehyde reductase, HvADH2, iron-containing alcohol dehydrogenase, KpADH, L-hexonate dehydrogenase, LB-RADH, LBADH, liver alcohol dehydrogenase, low-Km aldehyde reductase, mevaldate reductase, Mpd1, NADP(H)-dependent alcohol dehydrogenase, NADP+-dependent alcohol dehydrogenase, NADP-alcohol dehydrogenase, NADP-aldehyde reductase, NADP-dependent aldehyde reductase, NADP-linked aryl alcohol dehydrogenase, NADPH-aldehyde reductase, NADPH-cytochrome c reductase, NADPH-dependent ADH, NADPH-dependent aldehyde reductase, NADPH-dependent FALDR, NADPH-dependent fatty aldehyde reductase, NADPH-linked aldehyde reductase, nonspecific succinic semialdehyde reductase, Octopine dehydrogenase, putative iron alcohol dehydrogenase, PyAeADHII, rabbit kidney aldehyde-ketone reductase, RADH, ScADHVI, short-chain ADH, short-chain alcohol dehydrogenase, short-chain dehydrogenase/reductase, TBADH, TbADH1, Teth39_1597, Teth514_0564, TPN-L-hexonate dehydrogenase, TPNH-linked aldehyde reductase, TPNH-specific aldehyde reductase, triphosphopyridine nucleotide-linked aldehyde reductase, TsAdh319, Y63 protein, yeast alcohol dehydrogenase, YqhD

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.2 alcohol dehydrogenase (NADP+)

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Results	in table
11	Activating Compound
3079	AA Sequence
50	Application
1	CAS Registry Number
41	Cloned(Commentary)
97	Cofactor
25	Crystallization (Commentary)
1016	Disease/ Diagnostics
2	Expression
12	General Information
9	General Stability
33	IC50 Value
349	Inhibitors
70	kcat/KM [mM/s]
2	Ki Value [mM]
666	KM Value [mM]
36	Localization
29	Metals/Ions
171	Molecular Weight [Da]
234	Natural Substrates/ Products (Substrates)
7	Organic Solvent Stability
378	Organism
4	Oxidation Stability
18	Pathway
108	PDB ID
79	pH Optimum
12	pH Range
4	pH Stability
5	pI Value
63	Protein Variants
83	Purification (Commentary)
3	Reaction
5	Reaction Type
311	Reference
370	Source Tissue
149	Specific Activity [micromol/min/mg]
28	Storage Stability
1439	Substrates and Products (Substrate)
127	Subunits
167	Synonyms
1	Systematic Name
38	Temperature Optimum [°C]
5	Temperature Range [°C]
51	Temperature Stability [°C]
146	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.1.1.2 - alcohol dehydrogenase (NADP+)

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0802

(1H-indol-1-yl)acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0048

(2,3-dihydrocyclopenta[b]indol-4(1H)-yl)acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0406

(3-sulfanyl-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0012

(3-[[(2-fluorophenyl)methyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0235

(3-[[2-oxo-2-(2,4,6-trimethylanilino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.049

(4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indol-5-yl)acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0248

(6H-indolo[2,3-b]quinoxalin-6-yl)acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0151

(7H-indolo[2',3':5,6][1,2,4]triazino[2,3-a]benzimidazol-7-yl)acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0196

(8-methyl-3-[[2-oxo-2-(propylamino)ethyl]sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.000143

2-(2-oxo-3-phenethylquinoxalin-1(2H)-yl) acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.00082

2-(2-oxo-3-styrylquinoxalin-1(2H)-yl) acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.000283

2-(3-(2,4-difluorophenylamino)-6-nitro-2-oxoquinoxalin-1(2H)-yl) acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.00186

2-(3-(3-(tert-butylamino)-3-oxoprop-1-en-1-yl)-2-oxoquinoxalin-1(2H)-yl) acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.00753

2-(3-(4-(4-methoxyphenyl) piperazin-1-yl)-2-oxoquinoxalin-1(2H)-yl) acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.00114

2-(3-(4-fluorophenethyl)-2-oxoquinoxalin-1(2H)-yl) acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.00143

2-(3-(4-fluorostyryl)-2-oxoquinoxalin-1(2H)-yl) acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.000362

2-(3-(4-fluorostyryl)-6-nitro-2-oxoquinoxalin-1(2H)-yl)acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.00066

2-(6-chloro-3-(4-fluorostyryl)-2-oxoquinoxalin-1(2H)-yl)acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.00388

2-(7-chloro-2-oxo-3-styrylquinoxalin-1(2H)-yl) acetic acid

Rattus norvegicus

P51635

pH 7.2, 37°C, ALR1

738161

0.000044

20alpha-hydroxysteroid dehydrogenase

Sus scrofa

P50578

-

695864

-

0.011

3,5-dichlorosalicylic acid

Sus scrofa

P50578

-

695864

0.0118

3-(1H-indol-1-yl)propanoic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0067

3-[3-[(diethylamino)methyl]-1H-indol-1-yl]propanoic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0684

[3-(2,2-dimethylpropanoyl)-1H-indol-1-yl]acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0381

[3-[(diethylamino)methyl]-1H-indol-1-yl]acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0223

[3-[(dimethylamino)methyl]-2-methyl-1H-indol-1-yl]acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0325

[3-[(morpholin-4-yl)methyl]-1H-indol-1-yl]acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0141

[3-[(propan-2-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indol-5-yl]acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0192

[3-[(pyrrolidin-1-yl)methyl]-1H-indol-1-yl]acetic acid

Rattus norvegicus

P07943

pH and temperature not specified in the publication

738840

0.0054

[5-(3-carboxymethoxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid

2 entries

0.037

[5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid

2 entries

0.0054

[5-(3-carboxymethoxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid

Sus scrofa

P50578

25°C, pH 6.7

711903

0.0054

[5-(3-carboxymethoxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid

Sus scrofa

P50578

ALR1, pH not specified in the publication, temperature not specified in the publication

711903

0.037

[5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid

Sus scrofa

P50578

25°C, pH 6.7

711903

0.037

[5-(3-hydroxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid

Sus scrofa

P50578

ALR1, pH not specified in the publication, temperature not specified in the publication

711903