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release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide

-
-
-
-
release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
mechanism, cis-trans specificity
-
release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
acive site configuration, modeling, Asp449, Asp460, His523, Glu554, and Glu568 are in volved in metal binding in the active site, His429 and His523 are involved in shuttling protons during catalysis
-
release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
isozyme APP-2 shows a preference for Arg-Pro-Pro-, Arg-Pro-Lys-, Pro-Pro-Gly-, -Phe-Gly- in descending order
release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
H243 stabilizes substrate binding, H361 stabilizes substrate binding and the gem-diol catalytic intermediate. H350 forms part of a hydrophobic binding pocket that gives the enzyme its proline specificity
release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
R404 participates in proton relay and in the hydrogen bond network
-
release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
mechanism, cis-trans specificity
-
-
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(2-aminobenzoyl)-Lys-Pro-Pro-4-nitroanilide + H2O
?
(4-nitro)Phe-Pro-HN-CH2-CH2-NH-o-aminobenzoyl + H2O
(4-nitro)Phe + Pro-HN-CH2-CH2-NH-o-aminobenzoyl
-
-
-
?
(4-nitro)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl + H2O
(4-nitro)Phe + Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl
-
-
-
?
2-aminobenzoyl-L-Lys-L-Pro-L-Pro-4-nitroanilide + H2O
?
-
-
-
?
Abz-L-Lys-L-Pro-L-Pro-4-nitroanilide + H2O
Abz-L-Lys + L-Pro-L-Pro-4-nitroanilide
Abz-L-Lys-L-Pro-L-Pro-p-nitroanilide + H2O
Abz-L-Lys + L-Pro-L-Pro-p-nitroanilide
Ala-Pro-4-nitroanilide + H2O
Ala + Pro-4-nitroanilide
-
-
-
-
?
Ala-Pro-Gly + H2O
Ala + Pro-Gly
Ala-Pro-p-nitroanilide + H2O
Ala + Pro-p-nitroanilide
-
-
-
-
?
Ala-Pro-Tyr-Ala + H2O
Ala + Pro-Tyr-Ala
allostatin 1 + H2O
Ala + ?
-
-
cleavage of the Ala1-Pro2 bond
?
APKPKFIRF-amide + H2O
?
-
-
-
-
?
Arg-homoPro-Pro-Ala-NH2 + H2O
?
-
-
-
-
?
Arg-Pro + H2O
Arg + Pro
-
-
-
-
?
Arg-Pro-Ala + H2O
Arg + Pro-Ala
Arg-Pro-Lys-Pro + H2O
?
-
-
-
-
?
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Leu-Gly-Met-NH2 + H2O
?
-
-
-
-
?
Arg-Pro-Pro + H2O
Arg + Pro-Pro
Arg-Pro-Pro-benzylamide + H2O
Arg + Pro-Pro-benzylamide
-
-
-
-
?
Arg-Pro-Pro-Gly-Phe + H2O
?
Arg-Pro-Pro-Gly-Phe-Ser + H2O
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro + H2O
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + H2O
?
-
-
-
-
?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Arg + Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Asp-Pro-Gly-Phe-Tyr + H2O
?
-
-
-
-
?
beta-casomorphin + H2O
?
-
-
-
-
?
bradykinin + H2O
Arg + des-Arg-bradykinin
bradykinin + H2O
Arg + PPGFSPFR
i.e. RPPGFSPFR, rapid hydrolysis of the N-terminal Arg1-Pro2 bond
-
?
bradykinin + H2O
des-Arg-bradykinin + Arg
i.e. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
-
-
?
bradykinin + H2O
des-Arg-bradykinin + L-Arg
-
-
-
-
?
bradykinin + H2O
L-Arg + des-Arg-bradykinin
-
-
-
-
?
centrosomal protein 290 kDa/NPHP6 + H2O
?
-
ciliary proteome is screened for proteins with a proline in the second position: 3 candidate substrates centrosomal protein 290 kDa/NPHP6 (CEP290/NPHP6), Alstrom syndrome 1 (ALMS1), and leucine rich repeat containing 50 (LRRC50), known to cause cystic renal disease are shown to be cleaved by ecAPP
-
-
?
des-Arg9-bradykinin + H2O
?
-
-
-
-
?
FLRF-amide + H2O
?
-
-
-
-
?
FMRF-amide + H2O
?
-
-
-
-
?
FPHFD + H2O
?
-
globin pentapeptide sequence, potential natural substrate, efficiently hydrolyzed by PfAPP
-
-
?
FPHFD + H2O
L-Phe + PHFD
-
a hemoglobin peptide
-
-
?
Glu-Pro-p-nitroanilide + H2O
Glu + Pro-p-nitroanilide
-
-
-
-
?
Gly-Pro-2-naphthylamide + H2O
Gly + Pro-2-naphthylamide
-
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly + Pro-4-methylcoumarin 7-amide
Gly-Pro-4-nitroanilide + H2O
Gly + Pro-4-nitroanilide
Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Gly + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
Gly-Pro-Ala + H2O
Gly + Pro-Ala
Gly-Pro-Arg-Pro + H2O
?
-
-
-
-
?
Gly-Pro-Gly-Gly + H2O
Gly + Pro-Gly-Gly
-
-
-
?
Gly-Pro-hydroxyPro + H2O
Gly + Pro-hydroxyPro
-
-
-
?
Gly-Pro-Hyp + H2O
Gly + Pro-Hyp
Gly-Pro-p-nitroanilide + H2O
Gly + Pro-p-nitroanilide
-
-
-
-
?
Gly-Pro-Pro-p-nitroanilide + H2O
Gly + Pro-Pro-p-nitroanilide
-
-
-
-
?
His-Pro-p-nitroanilide + H2O
His + Pro-p-nitroanilide
-
-
-
-
?
K(Dnp)PPGFSPK(Abz)NH2 + H2O
?
-
-
-
-
?
K(Dnp)PPGK(Abz)NH2 + H2O
?
-
-
-
-
?
K(Dnp)PPK(Abz)NH2 + H2O
?
-
-
-
-
?
KHEYLRF-amide + H2O
?
-
-
-
-
?
KNEFIRF-amide + H2O
?
-
-
-
-
?
KPNFLRF-amide + H2O
?
-
-
-
-
?
KPSFVRF-amide + H2O
?
-
-
-
-
?
KPSFVRFamide + H2O
Lys + PSFVRFamide
-
a neuropeptide
-
?
L-Ala-L-Pro-4-nitroanilide + H2O
L-Ala + L-Pro-4-nitroanilide
L-Ala-L-Pro-L-Ala
L-Ala + L-Pro-L-Ala
-
-
-
?
L-Ala-L-Pro-L-Ala + H2O
L-Ala + L-Pro-L-Ala
L-Ala-L-Pro-L-Ala-2-naphthylamide + H2O
L-Ala-L-Pro-L-Ala + 2-naphthylamine
-
-
-
?
L-Ala-L-Pro-p-nitroanilide + H2O
L-Ala-L-Pro + p-nitroaniline
-
-
-
?
L-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Ala + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Arg-L-Pro-L-Pro + H2O
L-Arg + L-Pro-L-Pro
-
-
-
-
?
L-Arg-L-Pro-L-Pro-Gly + H2O
L-Arg + L-Pro-L-Pro-Gly
-
-
-
-
?
L-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Arg + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Asn-L-Pro-L-Thr-L-Asn-L-Leu-L-His + H2O
L-Asn + L-Pro-L-Thr-L-Asn-L-Leu-L-His
-
-
-
-
?
L-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-ASn + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Asp + Pro-7-amido-4-carbamoylmethylcoumarin
-
low activity
-
-
?
L-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Gln + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Glu + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-His + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Ile-L-Pro-L-Pro + H2O
L-Ile + L-Pro-L-Pro
-
-
-
-
?
L-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Ile + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Leu 7-amido-4-carbamoylmethylcoumarin + H2O
L-Leu + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Leu-L-Pro-L-Pro + H2O
L-Leu + L-Pro-L-Pro
-
-
-
-
?
L-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Lys + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Met-L-Ala-L-Ser + H2O
L-Met + L-Ala-L-Ser
-
-
-
-
?
L-Met-L-Pro + H2O
L-Met + L-Pro
L-Met-L-Pro-Gly + H2O
L-Met + L-Pro-Gly
L-Met-L-Ser-Gly + H2O
L-Met + L-Ser-Gly
-
-
-
-
?
L-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Met + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Nle-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Nle + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Phe-L-Pro-Gly + H2O
L-Phe + L-Pro-Gly
L-Phe-L-Pro-L-Ala + H2O
L-Phe + L-Pro-L-Ala
L-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Phe + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Pro + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-prolyl-peptide + H2O
L-proline + peptide
-
X-prolyl aminopeptidase catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides
-
-
?
L-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Ser + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Thr + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Trp + Pro-7-amido-4-carbamoylmethylcoumarin
-
best substrate
-
-
?
L-Tyr-L-Pro-L-Phe-NH2 + H2O
L-Tyr + L-Pro-L-Phe-NH2
-
-
-
-
?
L-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Tyr + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
L-Val-L-Pro-L-Leu + H2O
L-Val + L-Pro-L-Leu
-
-
-
?
L-Val-L-Pro-L-Pro + H2O
L-Val + L-Pro-L-Pro
-
-
-
-
?
L-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
L-Val + Pro-7-amido-4-carbamoylmethylcoumarin
-
-
-
-
?
LemTRP-1 + H2O
Ala + PSGFLGVRamide
-
i.e. APSGFLGVRamide
-
?
Leu-4-nitroanilide + H2O
Leu + 4-nitroaniline
-
-
-
-
?
Leu-Ala-Pro + H2O
Leu + Ala-Pro
-
-
-
-
?
Leu-Pro-Gly-Gly + H2O
Leu + Pro-Gly-Gly
-
-
-
?
Leu-Pro-Pro + H2O
Leu + Pro-Pro
-
-
-
-
?
leucine rich repeat containing 50 + H2O
?
-
ciliary proteome is screened for proteins with a proline in the second position: 3 candidate substrates centrosomal protein 290 kDa/NPHP6 (CEP290/NPHP6), Alstrom syndrome 1 (ALMS1), and leucine rich repeat containing 50 (LRRC50), known to cause cystic renal disease are shown to be cleaved by ecAPP
-
-
?
Lys(epsilon-dinitrophenol)-Pro-Pro-NH-CH3-CH2-NH-2-aminobenzoyl + H2O
Lys(epsilon-dinitrophenol) + Pro-Pro-NH-CH3-CH2-NH-2-aminobenzoyl
Lys-Pro-Arg + H2O
Lys + Pro-Arg
-
-
-
-
?
Lys-Pro-p-nitroanilide + H2O
Lys + Pro-p-nitroanilide
-
-
-
-
?
Met-Ala-Ala + H2O
Met + Ala-Ala
Met-Pro-Ala + H2O
Met + Pro-Ala
N6-(2-aminobenzoyl)-L-Lys-L-Pro-L-Pro-4-nitroanilide + H2O
N6-(2-aminobenzoyl)-L-Lys + Pro-Pro-4-nitroanilide
Nalpha-(2-aminobenzoyl)-Lys-Pro-Pro 4-nitroanilide + H2O
Nalpha-(2-aminobenzoyl)-Lys + Pro-Pro-4-nitroanilide
-
-
?
Nepsilon-(2-aminobenzoyl)-Lys-Pro-Pro-4-nitroanilide + H2O
?
-
-
-
-
?
neuropeptide Y + H2O
Tyr + ?
-
-
cleavage of the Try1-Pro2 bond
?
papain + H2O
?
-
reduced and carboxymethylated, with the N-terminal sequence Ile-Pro-Glu-Tyr-Val
-
-
?
PPGFSPFR + H2O
Pro + PGFSPFR
low activity
-
?
Pro-Pro-Gly-(Pro-Pro-Gly)4 + H2O
?
-
-
-
-
?
RNKFEFIRF-amide + H2O
?
-
-
-
-
?
RPPGFSPFR + H2O
L-Arg + PPGFSPFR
-
i.e. bradykinin
-
-
?
Ser-Pro + H2O
Ser + Pro
-
-
-
?
Ser-Pro-p-nitroanilide + H2O
Ser + Pro-p-nitroanilide
-
-
-
-
?
Substance P + H2O
?
-
-
-
-
?
substance P + H2O
Arg + des-Arg-substance P
substance P + H2O
Arg + PKPQQFFGLM
i.e. RPKPQQFFGLM, hydrolysis of the N-terminal Arg1-Pro2 bond
-
?
substance P + H2O
L-Arg + PKPQQFFGLM
-
-
-
?
Tyr-Ala-Ala + H2O
Tyr + Ala-Ala
Tyr-Pro-Ala + H2O
Tyr + Pro-Ala
Tyr-Pro-Leu-Gly-NH2 + H2O
?
-
-
-
-
?
Tyr-Pro-Phe + H2O
?
-
-
-
-
?
Tyr-Pro-Phe-Pro + H2O
?
-
-
-
-
?
Tyr-Pro-Phe-Pro-Gly + H2O
?
Tyr-Pro-Phe-Pro-Gly-Pro-Ile + H2O
?
YPWTQ + H2O
?
-
globin pentapeptide sequence, potential natural substrate, efficiently hydrolyzed by PfAPP
-
-
?
YPWTQ + H2O
L-Tyr + PWTQ
-
a hemoglobin peptide
-
-
?
additional information
?
-
(2-aminobenzoyl)-Lys-Pro-Pro-4-nitroanilide + H2O

?
-
-
-
-
?
(2-aminobenzoyl)-Lys-Pro-Pro-4-nitroanilide + H2O
?
-
-
-
-
?
Abz-L-Lys-L-Pro-L-Pro-4-nitroanilide + H2O

Abz-L-Lys + L-Pro-L-Pro-4-nitroanilide
-
-
-
?
Abz-L-Lys-L-Pro-L-Pro-4-nitroanilide + H2O
Abz-L-Lys + L-Pro-L-Pro-4-nitroanilide
-
-
-
?
Abz-L-Lys-L-Pro-L-Pro-p-nitroanilide + H2O

Abz-L-Lys + L-Pro-L-Pro-p-nitroanilide
-
-
-
-
?
Abz-L-Lys-L-Pro-L-Pro-p-nitroanilide + H2O
Abz-L-Lys + L-Pro-L-Pro-p-nitroanilide
-
-
-
-
?
Ala-Pro + H2O

Ala + Pro
-
-
-
?
Ala-Pro + H2O
Ala + Pro
-
-
-
?