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Literature summary for 3.4.11.9 extracted from

  • Cordova, A.; Woodrick, J.; Grindrod, S.; Zhang, L.; Saygideger-Kont, Y.; Wang, K.; DeVito, S.; Daniele, S.G.; Paige, M.; Brown, M.L.
    Aminopeptidase P mediated targeting for breast tissue specific conjugate delivery (2016), Bioconjug. Chem., 27, 1981-1990 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.9

Protein Variants

Protein Variants Comment Organism
additional information design of an aminopeptidase P (APaseP) targeting tissue-specific construct conjugated to a homing peptide for selective binding to human breast-derived cancer cells. Homing peptides are short amino acid sequences derived from phage display libraries that have the unique property of localizing to specific organs. The molecular construct allows for tissue-specific drug delivery, by binding to APaseP in the vascular endothelium. The breast homing peptide is a cyclic nine-amino-acid peptide with the sequence CPGPEGAGC, referred to as PEGA. The PEGA peptide and similar peptide conjugates distribute to human breast tissue xenograft specifically and evaluate the interaction with the membrane-bound proline-specific APaseP by binding studies. In vivo localization of the breast tissue specific conjugate in a breast cancer xenograft mouse model, established by implanting enzyme-expressing human breast adenocarcinoma cell line MCF-7 in nude mice with estrogen supplementation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O43895
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information a proline-specific APaseP Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase P
-
 Homo sapiens
APaseP
-
 Homo sapiens
membrane-bound proline-specific APaseP
-
 Homo sapiens
XPNEP2
-
 Homo sapiens