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Literature summary for 3.4.11.9 extracted from
- Fluorogenic substrates for bacterial aminopeptidase P and its analogs detected in human serum and calf lung (1982), Eur. J. Biochem., 125, 609-615.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-Phe(NO2)-Pro-Pro-HN-CH2-CH2-NH-2-aminobenzoyl | 0.5 mM, 30% inhibition of hydrolysis of (4-nitr)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl | Escherichia coli |  |
| EDTA | - |
Bos taurus | |
| EDTA | - |
Escherichia coli | |
| Pro-Gly-Pro | - |
Escherichia coli | |
| Pro-HN-CH2-CH2-NH-2-aminobenzoyl | - |
Bos taurus | |
| Pro-HN-CH2-CH2-NH-2-aminobenzoyl | 0.01 mM, complete inhibition of hydrolysis of (4-nitro)Phe-Pro-Pro-HN-CH2-CH2-NH-2-aminobenzoyl | Escherichia coli | |
| Pro-HN-CH2-CH2-NH-2-aminobenzoyl | - |
Homo sapiens | |
| Pro-Pro-Ala | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.22 | - |
(4-nitro)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl | - |
Escherichia coli | |
| 3 | - |
(4-nitro)Phe-Pro-HN-CH2-CH2-NH-o-aminobenzoyl | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
| partial | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Bos taurus | - |
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (4-nitro)Phe-Pro-HN-CH2-CH2-NH-o-aminobenzoyl + H2O | - |
Escherichia coli | (4-nitro)Phe + Pro-HN-CH2-CH2-NH-o-aminobenzoyl | - |
? | |
| (4-nitro)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl + H2O | - |
Escherichia coli | (4-nitro)Phe + Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl | - |
? | |
| Arg-Pro-Pro + H2O | - |
Bos taurus | Arg + Pro-Pro | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 20 | - |
(4-nitro)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl | - |
Escherichia coli | |
| 135 | - |
(4-nitro)Phe-Pro-HN-CH2-CH2-NH-o-aminobenzoyl | - |
Escherichia coli | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Escherichia coli |
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Release 2023.1 (January 2023)
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