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Literature summary for 3.4.11.9 extracted from

  • Fleminger, G.; Carmel, A.; Goldenberg, D.; Yaron, A.
    Fluorogenic substrates for bacterial aminopeptidase P and its analogs detected in human serum and calf lung (1982), Eur. J. Biochem., 125, 609-615.
    View publication on PubMed
Search for more literature for 3.4.11.9

Inhibitors

Inhibitors Comment Organism Structure
acetyl-Phe(NO2)-Pro-Pro-HN-CH2-CH2-NH-2-aminobenzoyl 0.5 mM, 30% inhibition of hydrolysis of (4-nitr)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl Escherichia coli
EDTA
-
 Bos taurus
EDTA
-
 Escherichia coli
Pro-Gly-Pro
-
 Escherichia coli
Pro-HN-CH2-CH2-NH-2-aminobenzoyl
-
 Bos taurus
Pro-HN-CH2-CH2-NH-2-aminobenzoyl 0.01 mM, complete inhibition of hydrolysis of (4-nitro)Phe-Pro-Pro-HN-CH2-CH2-NH-2-aminobenzoyl Escherichia coli
Pro-HN-CH2-CH2-NH-2-aminobenzoyl
-
 Homo sapiens
Pro-Pro-Ala
-
 Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.22
-
 (4-nitro)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl
-
 Escherichia coli
3
-
 (4-nitro)Phe-Pro-HN-CH2-CH2-NH-o-aminobenzoyl
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 calf
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli
partial Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Bos taurus
-
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(4-nitro)Phe-Pro-HN-CH2-CH2-NH-o-aminobenzoyl + H2O
-
 Escherichia coli (4-nitro)Phe + Pro-HN-CH2-CH2-NH-o-aminobenzoyl
-
 ?
(4-nitro)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl + H2O
-
 Escherichia coli (4-nitro)Phe + Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl
-
 ?
Arg-Pro-Pro + H2O
-
 Bos taurus Arg + Pro-Pro
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
20
-
 (4-nitro)Phe-Pro-Pro-HN-CH2-CH2-NH-o-aminobenzoyl
-
 Escherichia coli
135
-
 (4-nitro)Phe-Pro-HN-CH2-CH2-NH-o-aminobenzoyl
-
 Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
 Escherichia coli