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Literature summary for 3.4.11.9 extracted from
- Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease (2017), Oncotarget, 8, 100066-100078 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene XPNPEP-1, quantitative enzyme expression analysis | Homo sapiens |
| gene XPNPEP-2, quantitative enzyme expression analysis | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | downregulation of XPNPEP1 in 786-O cells by stable transduction with small-hairpin (sh)RNAs | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| plasma membrane | XPNPEP2 is glycophosphatidylinositol (GPI) anchored on the cytosolic side of the plasma membrane | Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | required for activity | Homo sapiens |  |
| additional information | XPNPEP1 is a metallopeptidase | Homo sapiens | |
| additional information | XPNPEP2 is a metallopeptidase | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O43895 | - |
- |
| Homo sapiens | Q9NQW7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 786-O cell | - |
Homo sapiens | - |
| kidney cancer cell | upregulation of Xaa-Pro aminopeptidase-1, XPNPEP-1, in renal cell carcinoma from von Hippel-Lindau patients, and a strong decrease of XPNPEP-2, quantitative proteomic analysis, overview | Homo sapiens | - |
| renal cell carcinoma cell line | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Xaa-Pro aminopeptidase-1 | - |
Homo sapiens |
| Xaa-Pro aminopeptidase-2 | - |
Homo sapiens |
| XPNPEP-1 | - |
Homo sapiens |
| XPNPEP-2 | - |
Homo sapiens |
| XPNPEP1 | - |
Homo sapiens |
| XPNPEP2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | isozymes XPNPEP1 and -2 have comparable structural properties and similar substrate specificities | Homo sapiens |
| physiological function | Xaa-Pro aminopeptidase-1 is an anti-proliferative and anti-migratory exoprotease. Differential expression of Xaa-Pro aminopeptidases 1 and 2 in renal cancer, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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