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Literature summary for 3.4.11.9 extracted from

  • Orawski, A.T.; Susz, J.P.; Simmons, W.H.
    Aminopeptidase P from bovine lung: solubilization, properties, and potential role in bradykinin degradation (1987), Mol. Cell. Biochem., 75, 123-132.
    View publication on PubMed
Search for more literature for 3.4.11.9

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Bos taurus
2-mercaptoethanol
-
 Bos taurus
4-chloromercuriphenyl sulfonic acid inhibits cleavage of Arg-Pro-Pro Bos taurus
amastatin
-
 Bos taurus
diisopropylphosphofluoridate
-
 Bos taurus
PCMB inhibits cleavage of Arg-Pro-Pro Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.93
-
 Arg-Pro-Pro
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus the enzyme may have an important role in the pulmonary degradation of the potent vasoactive peptide, bradykinin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-Pro-Pro + H2O
-
 Bos taurus Arg + Pro-Pro
-
 ?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
-
 Bos taurus Arg + Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
-
 ?
Gly-Pro-Hyp + H2O
-
 Bos taurus Gly + Pro-Hyp
-
 ?
additional information the enzyme may have an important role in the pulmonary degradation of the potent vasoactive peptide, bradykinin Bos taurus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 hydrolysis of Arg-Pro-Pro Bos taurus