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Literature summary for 3.4.11.9 extracted from

  • Lloyd, G.S.; Hryszko, J.; Hooper, N.M.; Turner, A.J.
    Inhibition and metal ion activation of pig kidney aminopeptidase P. Dependence on nature of substrate (1996), Biochem. Pharmacol., 52, 229-236.
    View publication on PubMed
Search for more literature for 3.4.11.9

Activating Compound

Activating Compound Comment Organism Structure
4-chloromercuriphenyl sulfonic acid inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
4-chloromercuriphenyl sulfonic acid inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin Sus scrofa
bradykinin hydrolysis of Gly-Pro-Hyp Sus scrofa
cilazaprilat inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methyl-7-coumarylamide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin Sus scrofa
enaprilat inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methylcoumarin 7-amide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin Sus scrofa
Mn2+ above, 0.01 mM, hydrolysis of bradykinin and Arg-Pro-Pro Sus scrofa
ramiprilat inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methylcoumarin 7-amide, substance P or beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7
-
 Gly-Pro-Hyp
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ 4-10 mM, activates hydrolysis of Gly-Pro-Hyp, beta-casomorphin or substance P Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney brush border membrane Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-Pro-Pro + H2O
-
 Sus scrofa Arg + Pro-Pro
-
 ?
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
-
 Sus scrofa Arg + Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
-
 ?
beta-casomorphin + H2O
-
 Sus scrofa ?
-
 ?
Gly-Pro-Hyp + H2O
-
 Sus scrofa Gly + Pro-Hyp
-
 ?
Substance P + H2O
-
 Sus scrofa ?
-
 ?