Reference on EC 3.1.8.1 - aryldialkylphosphatase and Organism(s) Homo sapiens and UniProt Accession P27169
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gonzalo, M.C.; Gil, F.; Hernandez, A.F.; Rodrigo, L.; Villanueva, E.; Pla, A.
Human liver paraoxonase (PON1): subcellular distribution and characterization
J. Biochem. Mol. Toxicol.
12
61-69
1998
Homo sapiens
Reiner, E.; Simeon-Rudolf, V.; Skrinjaric-Spoljar, M.
Catalytic properties and distribution profiles of paraoxonase and cholinesterase phenotypes in human sera
Toxicol. Lett.
82/83
447-452
1995
Homo sapiens
Aviram, M.; Rosenblatt, M.; Bisgaier, C.L.; Newton, R.S.; Primo-Parmo, S.L.; La Du, B.N.
Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
J. Clin. Invest.
101
1581-1590
1998
Homo sapiens
Hernandez, A.F.; Pla, A.; Valenzuela, A.; Gil, F.; Villanueva, E.
Characterization of paraoxonase activity in pericardial fluid: usefulness as a marker of coronary disease
Chem. Biol. Interact.
87
173-177
1993
Homo sapiens
Gan, K.N.; Smolen, A.; Eckerson, H.W.; La Du, B.N.
Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities
Drug Metab. Dispos.
19
100-106
1991
Homo sapiens
Smolen, A.; Eckerson, H.W.; Gan, K.N.; Hailat, N.; La Du, B.N.
Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase
Drug Metab. Dispos.
19
107-112
1991
Homo sapiens
Haagen, L.; Brock, A.
A new automated method for phenotyping arylesterase (EC 3.1.1.2) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate
Eur. J. Clin. Chem. Clin. Biochem.
30
391-395
1992
Homo sapiens
Nishio, E.; Watanabe, Y.
Cigarette smoke extract inhibits plasma paraoxonase activity by modification of the enzyme s free thiols
Biochem. Biophys. Res. Commun.
236
289-293
1997
Homo sapiens
Tanaka-Kawai, H.; Yomoda, S.
Molecular weight and substrate characteristics of human serum arylesterase following purification by immuno-affinity chromatography
Clin. Chim. Acta
215
127-138
1993
Homo sapiens
Furlong, C.E.; Richter, R.J.; Chapline, C.; Crabb, J.W.
Purification of rabbit and human serum paraoxonase
Biochemistry
30
10133-10140
1991
Oryctolagus cuniculus, Homo sapiens
Mackness, M.I.; Thompson, H.M.; Hardy, A.R.; Walker, C.H.
Distinction between A-esterases and arylesterases. Implications for esterase classification
Biochem. J.
245
293-296
1987
Bos taurus, Felis catus, Homo sapiens, Hydrochoerus hydrochaeris, Meles taxus, Mus musculus, no activity in aves, Rattus norvegicus, Sus scrofa
Mackness, M.I.; Arrol, S.; Durrington, P.N.
Substrate specificity of human serum paraoxonase
Biochem. Soc. Trans.
19
304S
1991
Homo sapiens
Hassett, C.; Richter, R.J.; Humbert, R.; Chapline, C.; Crabb, J.W.; Omiecinski, C.J.; Furlong, C.E.
Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence
Biochemistry
30
10141-10149
1991
Oryctolagus cuniculus, Homo sapiens
La Du, B.N.; Adkins, S.; Kuo, C.L.; Lipsig, D.
Studies on human serum paraoxonase/arylesterase
Chem. Biol. Interact.
87
25-34
1993
Homo sapiens
Pellin, M.C.; Moretto, A.; Lotti, M.; Vilanova, E.
Distribution and some biochemical properties of rat paraoxonase activity
Neurotoxicol. Teratol.
12
611-614
1990
Homo sapiens, Rattus norvegicus
Josse, D.; Ebel, C.; Stroebel, D.; Fontaine, A.; Borges, F.; Echalier, A.; Baud, D.; Renault, F.; le Maire, M.; Chabrieres, E.; Masson, P.
Oligomeric states of the detergent-solubilized human serum paraoxonase (PON1)
J. Biol. Chem.
277
33386-33397
2002
Homo sapiens
Deakin, S.; Leviev, I.; Gomaraschi, M.; Calabresi, L.; Franceschini, G.; James, R.W.
Enzymatically active paraoxonase-1 is located at the external membrane of producing cells and released by a high affinity, saturable, desorption mechanism
J. Biol. Chem.
277
4301-4308
2002
Homo sapiens
Ng, C.J.; Wadleigh, D.J.; Gangopadhyay, A.; Hama, S.; Grijalva, V.R.; Navab, M.; Fogelman, A.M.; Reddy, S.T.
Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein
J. Biol. Chem.
276
44444-44449
2001
Homo sapiens
Sorenson, R.C.; Primo-Parmo, S.L.; Kuo, C.L.; Adkins, S.; Lockridge, O.; La Du, B.N.
Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase
Proc. Natl. Acad. Sci. USA
92
7187-7191
1995
Homo sapiens
Costa, L.G.; Li, W.F.; Richter, R.J.; Shih, D.M.; Lusis, A.; Furlong, C.E.
The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism
Chem. Biol. Interact.
119-120
429-438
1999
Homo sapiens
Kuo, C.L.; La Du, B.N.
Comparison of purified human and rabbit serum paraoxonases
Drug Metab. Dispos.
23
935-944
1995
Oryctolagus cuniculus, Homo sapiens
La Du, B.N.; Billecke, S.; Hsu, C.; Haley, R.W.; Broomfield, C.A.
Serum paraoxonase (PON1) isozymes: the quantitative analysis of isozymes affecting individual sensitivity to environmental chemicals
Drug Metab. Dispos.
29
566-569
2001
Homo sapiens (P27169)
Serhatlioglu, S.; Gursu, M.F.; Gulcu, F.; Canatan, H.; Godekmerdan, A.
Levels of paraoxonase and arylesterase activities and malondialdehyde in workers exposed to ionizing radiation
Cell Biochem. Funct.
21
371-375
2003
Homo sapiens
Ahmed, Z.; Babaei, S.; Maguire, G.F.; Draganov, D.; Kuksis, A.; La Du, B.N.; Connelly, P.W.
Paraoxonase-1 reduces monocyte chemotaxis and adhesion to endothelial cells due to oxidation of palmitoyl, linoleoyl glycerophosphorylcholine
Cardiovasc. Res.
57
225-231
2003
Homo sapiens
Ahmed, Z.; Ravandi, A.; Maguire, G.F.; Emili, A.; Draganov, D.; La Du, B.N.; Kuksis, A.; Connelly, P.W.
Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite
Biochem. Biophys. Res. Commun.
290
391-396
2002
Homo sapiens
Leviev, I.; Deakin, S.; James, R.W.
Decreased stability of the M54 isoform of paraoxonase as a contributory factor to variations in human serum paraoxonase concentrations
J. Lipid Res.
42
528-535
2001
Homo sapiens
Doorn, J.A.; Sorenson, R.C.; Billecke, S.S.; Hsu, C.; La Du, B.N.
Evidence that several conserved histidine residues are required for hydrolytic activity of human paraoxonase/arylesterase
Chem. Biol. Interact.
119-120
235-241
1999
Homo sapiens
Costa, L.G.; Cole, T.B.; Furlong, C.E.
Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates
J. Toxicol. Clin. Toxicol.
41
37-45
2003
Homo sapiens
Kuo, C.L.; La Du, B.N.
Calcium binding by human and rabbit serum paraoxonases. Structural stability and enzymic activity
Drug Metab. Dispos.
26
653-660
1998
Oryctolagus cuniculus, Homo sapiens
Billecke, S.; Draganov, D.; Counsell, R.; Stetson, P.; Watson, C.; Hsu, C.; La Du, B.N.
Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters
Drug Metab. Dispos.
28
1335-1342
2000
Homo sapiens (P27169), Homo sapiens
Brushia, R.J.; Forte, T.M.; Oda, M.N.; La Du, B.N.; Bielicki, J.K.
Baculovirus-mediated expression and purification of human serum paraoxonase 1A
J. Lipid Res.
42
951-958
2001
Homo sapiens
Soukharev, S.; Hammond, D.J.
A fluorogenic substrate for detection of organophosphatase activity
Anal. Biochem.
327
140-148
2004
Homo sapiens
Gaidukov, L.; Tawfik, D.S.
High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I
Biochemistry
44
11843-11854
2005
Homo sapiens (P27169)
Khersonsky, O.; Tawfik, D.S.
Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase
Biochemistry
44
6371-6382
2005
Homo sapiens (P27169)
Sinan, S.; Kockar, F.; Gencer, N.; Yildirim, H.; Arslan, O.
Amphenicol and macrolide derived antibiotics inhibit paraoxonase enzyme activity in human serum and human hepatoma cells (HepG2) in vitro
Biochemistry (Moscow)
71
46-50
2006
Homo sapiens
Yeung, D.T.; Josse, D.; Nicholson, J.D.; Khanal, A.; McAndrew, C.W.; Bahnson, B.J.; Lenz, D.E.; Cerasoli, D.M.
Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model
Biochim. Biophys. Acta
1702
67-77
2004
Homo sapiens, Homo sapiens (P27169)
Bergmeier, C.; Siekmeier, R.; Gross, W.
Distribution spectrum of paraoxonase activity in HDL fractions
Clin. Chem.
50
2309-2315
2004
Homo sapiens
Costa, L.G.; Cole, T.B.; Vitalone, A.; Furlong, C.E.
Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity
Clin. Chim. Acta
352
37-47
2005
Homo sapiens
Yeung, D.T.; Lenz, D.E.; Cerasoli, D.M.
Analysis of active-site amino-acid residues of human serum paraoxonase using competitive substrates
FEBS J.
272
2225-2230
2005
Homo sapiens (P27169), Homo sapiens
James, R.W.; Deakin, S.P.
The importance of high-density lipoproteins for paraoxonase-1 secretion, stability, and activity
Free Radic. Biol. Med.
37
1986-1994
2004
Homo sapiens, Mus musculus
Khersonsky, O.; Tawfik, D.S.
The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases
J. Biol. Chem.
281
7649-7656
2006
Homo sapiens (P27169)
Draganov, D.I.; Teiber, J.F.; Speelman, A.; Osawa, Y.; Sunahara, R.; La Du, B.N.
Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
J. Lipid Res.
46
1239-1247
2005
Homo sapiens (P27169), Homo sapiens (Q15166)
Briseno-Roa, L.; Hill, J.; Notman, S.; Sellers, D.; Smith, A.P.; Timperley, C.M.; Wetherell, J.; Williams, N.H.; Williams, G.R.; Fersht, A.R.; Griffiths, A.D.
Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents
J. Med. Chem.
49
246-255
2006
Brevundimonas diminuta, Homo sapiens
Harel, M.; Aharoni, A.; Gaidukov, L.; Brumshtein, B.; Khersonsky, O.; Meged, R.; Dvir, H.; Ravelli, R.B.G.; McCarthy, A.; Toker, L.; Silman, I.; Sussman, J.L.; Tawfik, D.S.
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes
Nat. Struct. Mol. Biol.
11
412-419
2004
Homo sapiens (P27169)
Aharoni, A.; Gaidukov, L.; Yagur, S.; Toker, L.; Silman, I.; Tawfik, D.S.
Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization
Proc. Natl. Acad. Sci. USA
101
482-487
2004
Homo sapiens (P27169), Homo sapiens (Q15166), Mus musculus (Q62087), Oryctolagus cuniculus (Q9BGN0)
Kiderlen, D.; Eyer, P.; Worek, F.
Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1)
Biochem. Pharmacol.
69
1853-1867
2005
Homo sapiens
Costa, L.G.; Vitalone, A.; Cole, T.B.; Furlong, C.E.
Modulation of paraoxonase (PON1) activity
Biochem. Pharmacol.
69
541-550
2005
Homo sapiens
Pasca, S.P.; Nemes, B.; Vlase, L.; Gagyi, C.E.; Dronca, E.; Miu, A.C.; Dronca, M.
High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism
Life Sci.
78
2244-2248
2006
Homo sapiens
Kilic, S.S.; Aydin, S.; Kilic, N.; Erman, F.; Celik, I.
Serum arylesterase and paraoxonase activity in patients with chronic hepatitis
World J. Gastroenterol.
11
7351-7354
2005
Homo sapiens (P27169), Homo sapiens
Sumegova, K.; Blazicek, P.; Waczulikova, I.; Zitnanova, I.; Durackova, Z.
Activity of paraoxonase 1 (PON1) and its relationship to markers of lipoprotein oxidation in healthy Slovaks
Acta Biochim. Pol.
53
783-787
2006
Homo sapiens (P27169)
Juretic, D.; Motejlkova, A.; Kunovi?, B.; Reki?, B.; Flegar-Mestri?, Z.; Vuji?, L.; Mesi?, R.; Lukac-Bajalo, J.; Simeon-Rudolf, V.
Paraoxonase/arylesterase in serum of patients with type II diabetes mellitus
Acta Pharm.
56
59-68
2006
Homo sapiens
Walker, J.P.; Kimble, K.W.; Asher, S.A.
Photonic crystal sensor for organophosphate nerve agents utilizing the organophosphorus hydrolase enzyme
Anal. Bioanal. Chem.
389
2115-2124
2007
Homo sapiens
Saruhan, E.; Olgun, A.; Oztuerk, K.; Akman, S.; Erbil, M.K.
Age-related paraoxonase activity changes in Turkish population
Ann. N. Y. Acad. Sci.
1100
218-222
2007
Homo sapiens
Muacevic-Katanec, D.; Bradamante, V.; Poljicanin, T.; Reiner, Z.; Babic, Z.; Simeon-Rudolf, V.; Katanec, D.
Clinical study on the effect of simvastatin on paraoxonase activity
Arzneimittelforschung
57
647-653
2007
Homo sapiens
Santanam, N.; Parthasarathy, S.
Aspirin is a substrate for paraoxonase-like activity: implications in atherosclerosis
Atherosclerosis
191
272-275
2007
Homo sapiens (P27169), Homo sapiens
Aslan, M.; Nazligul, Y.; Horoz, M.; Bolukbas, C.; Bolukbas, F.F.; Gur, M.; Celik, H.; Erel, O.
Serum paraoxonase-1 activity in Helicobacter pylori infected subjects
Atherosclerosis
196
270-274
2008
Homo sapiens
Rochu, D.; Chabriere, E.; Renault, F.; Elias, M.; Clery-Barraud, C.; Masson, P.
Stabilization of the active form(s) of human paraoxonase by human phosphate-binding protein
Biochem. Soc. Trans.
35
1616-1620
2007
Homo sapiens
Nguyen, S.D.; Sok, D.E.
Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position
Biochim. Biophys. Acta
1758
499-508
2006
Homo sapiens (P27169)
Rochu, D.; Renault, F.; Clery-Barraud, C.; Chabriere, E.; Masson, P.
Stability of highly purified human paraoxonase (PON1): Association with human phosphate binding protein (HPBP) is essential for preserving its active conformation(s)
Biochim. Biophys. Acta
1774
874-883
2007
Homo sapiens (P27169)
Sinan, S.; Kockar, F.; Arslan, O.
Novel purification strategy for human PON1 and inhibition of the activity by cephalosporin and aminoglikozide derived antibiotics
Biochimie
88
565-574
2006
Homo sapiens
Forrest, S.R.; Elmore, B.B.; Palmer, J.D.
Activity and lifetime of organophosphorous hydrolase (OPH) immobilized using layer-by-layer nano self-assembly on silicon microchannels
Catal. Today
120
30-34
2006
Homo sapiens
-
Sirivarasai, J.; Kaojarern, S.; Yoovathaworn, K.; Sura, T.
Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects
Chem. Biol. Interact.
168
184-192
2007
Homo sapiens (P27169), Homo sapiens
Can Demirdoegen, B.; Tuerkanoglu, A.; Bek, S.; Sanisoglu, Y.; Demirkaya, S.; Vural, O.; Arinc, E.; Adali, O.
Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischemic stroke
Clin. Biochem.
41
1-9
2008
Homo sapiens (P27169)
Schulpis, K.H.; Karikas, G.A.; Bartzeliotou, A.; Papakonstantinou, E.D.; Kalogerakou, M.; Tsakiris, S.
The effect of diet on paraoxonase 1/arylesterase activities in patients with disorders of galactose metabolism
Clin. Endocrinol. (Oxf.)
67
687-692
2007
Homo sapiens (P27169)
Isik, A.; Koca, S.S.; Ustundag, B.; Celik, H.; Yildirim, A.
Paraoxonase and arylesterase levels in rheumatoid arthritis
Clin. Rheumatol.
26
342-348
2007
Homo sapiens (P27169)
Catano, H.C.; Cueva, J.L.; Cardenas, A.M.; Izaguirre, V.; Zavaleta, A.I.; Carranza, E.; Hernandez, A.F.
Distribution of paraoxonase-1 gene polymorphisms and enzyme activity in a Peruvian population
Environ. Mol. Mutagen.
47
699-706
2006
Homo sapiens (P27169)
Schulpis, K.H.; Bartzeliotou, A.; Tsakiris, S.; Gounaris, A.; Papassotiriou, I.
Serum paraoxonase/arylesterase activities in phenylketonuric patients on diet
Eur. J. Clin. Nutr.
61
803-808
2007
Homo sapiens (P27169), Homo sapiens
Yeung, D.T.; Smith, J.R.; Sweeney, R.E.; Lenz, D.E.; Cerasoli, D.M.
Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase
FEBS J.
274
1183-1191
2007
Homo sapiens
Renault, F.; Chabriere, E.; Andrieu, J.; Dublet, B.; Masson, P.; Rochu, D.
Tandem purification of two HDL-associated partner proteins in human plasma, paraoxonase (PON1) and phosphate binding protein (HPBP) using hydroxyapatite chromatography
J. Chromatogr. B
836
15-21
2006
Homo sapiens (P27169)
Gaidukov, L.; Tawfik, D.S.
The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity
J. Lipid Res.
48
1637-1646
2007
Homo sapiens (P27169), Homo sapiens
Park, C.H.; Nguyen, S.D.; Kim, M.R.; Jeong, T.S.; Sok, D.E.
Differential effect of lysophospholipids on activities of human plasma paraoxonase1, either soluble or lipid-bound
Lipids
41
371-380
2006
Homo sapiens (P27169)
Kanamori-Kataoka, M.; Seto, Y.
Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R)
Anal. Biochem.
385
94-100
2009
Homo sapiens (P27169), Homo sapiens
Abd-Allah, G.M.; Mariee, A.D.
Nitrite-mediated inactivation of human plasma paraoxonase-1: possible beneficial effect of aromatic amino acids
Appl. Biochem. Biotechnol.
150
281-288
2008
Homo sapiens (P27169), Homo sapiens
Blum, M.M.; Timperley, C.M.; Williams, G.R.; Thiermann, H.; Worek, F.
Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase
Biochemistry
47
5216-5224
2008
Homo sapiens (P27169), Homo sapiens
Kotur-Stevuljevic, J.; Spasic, S.; Jelic-Ivanovic, Z.; Spasojevic-Kalimanovska, V.; Stefanovic, A.; Vujovic, A.; Memon, L.; Kalimanovska-Ostric, D.
PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients
Clin. Biochem.
41
1067-1073
2008
Homo sapiens (P27169)
Alici, H.A.; Ekinci, D.; Beydemir, S.
Intravenous anesthetics inhibit human paraoxonase-1 (PON1) activity in vitro and in vivo
Clin. Biochem.
41
1384-1390
2008
Homo sapiens (P27169), Homo sapiens
Schulpis, K.H.; Barzeliotou, A.; Papadakis, M.; Rodolakis, A.; Antsaklis, A.; Papassotiriou, I.; Vlachos, G.D.
Maternal chronic hepatitis B virus is implicated with low neonatal paraoxonase/arylesterase activities
Clin. Biochem.
41
282-287
2008
Homo sapiens (P27169), Homo sapiens
Yildiz, A.; Gur, M.; Demirbag, R.; Yilmaz, R.; Akyol, S.; Aslan, M.; Erel, O.
Paraoxonase and arylesterase activities in untreated dipper and non-dipper hypertensive patients
Clin. Biochem.
41
779-784
2008
Homo sapiens (P27169), Homo sapiens
Barim, A.O.; Aydin, S.; Colak, R.; Dag, E.; Deniz, O.; Sahin, I.
Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment
Clin. Biochem.
42
1076-1081
2009
Homo sapiens (P27169)
Kasprzak, M.; Iskra, M.; Majewski, W.; Wielkoszynski, T.
Arylesterase and paraoxonase activity of paraoxonase (PON1) affected by ischemia in the plasma of patients with arterial occlusion of the lower limbs
Clin. Biochem.
42
50-56
2009
Homo sapiens (P27169)
Garces, C.; Lopez-Simon, L.; Rubio, R.; Benavente, M.; Cano, B.; Ortega, H.; de Oya, M.
High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain
Clin. Chem. Lab. Med.
46
809-813
2008
Homo sapiens (P27169)
Kotani, K.; Kimura, S.; Tsuzaki, K.; Sakane, N.; Komada, I.; Schulze, J.; Gugliucci, A.
Reduced paraoxonase 1/arylesterase activity and its post-therapeutic increase in obstructive sleep apnea syndrome: A preliminary study
Clin. Chim. Acta
395
184-185
2008
Homo sapiens (P27169)
van den Berg, S.W.; Jansen, E.H.; Kruijshoop, M.; Beekhof, P.K.; Blaak, E.; van der Kallen, C.J.; van Greevenbroek, M.M.; Feskens, E.J.
Paraoxonase 1 phenotype distribution and activity differs in subjects with newly diagnosed Type 2 diabetes (the CODAM Study)
Diabet. Med.
25
186-193
2008
Homo sapiens (P27169)
Liu, Y.; Mackness, B.; Mackness, M.
Comparison of the ability of paraoxonases 1 and 3 to attenuate the in vitro oxidation of low-density lipoprotein and reduce macrophage oxidative stress
Free Radic. Biol. Med.
45
743-748
2008
Homo sapiens (P27169)
Camuzcuoglu, H.; Arioz, D.T.; Toy, H.; Kurt, S.; Celik, H.; Erel, O.
Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer
Gynecol. Oncol.
112
481-485
2009
Homo sapiens (P27169), Homo sapiens
Rock, W.; Rosenblat, M.; Miller-Lotan, R.; Levy, A.P.; Elias, M.; Aviram, M.
Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities
J. Agric. Food Chem.
56
8704-8713
2008
Homo sapiens (P27169)
Pasca, S.P.; Dronca, E.; Nemes, B.; Kaucsar, T.; Endreffy, E.; Iftene, F.; Benga, I.; Cornean, R.; Dronca, M.
Paraoxonase 1 activities and polymorphisms in autism spectrum disorders
J. Cell. Mol. Med.
14
600-607
2010
Homo sapiens
Stoltz, D.A.; Ozer, E.A.; Taft, P.J.; Barry, M.; Liu, L.; Kiss, P.J.; Moninger, T.O.; Parsek, M.R.; Zabner, J.
Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1
J. Clin. Invest.
118
3123-3131
2008
Homo sapiens (P27169)
Aksoy, H.; Aksoy, A.N.; Ozkan, A.; Polat, H.
Serum lipid profile, oxidative status, and paraoxonase 1 activity in hyperemesis gravidarum
J. Clin. Lab. Anal.
23
105-109
2009
Homo sapiens (P27169)
Jaichander, P.; Selvarajan, K.; Garelnabi, M.; Parthasarathy, S.
Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin
J. Lipid Res.
49
2142-2148
2008
Homo sapiens (P27169), Mus musculus (P52430)
Wills, A.M.; Landers, J.E.; Zhang, H.; Richter, R.J.; Caraganis, A.J.; Cudkowicz, M.E.; Furlong, C.E.; Brown, R.H.
Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS
Neurology
70
929-934
2008
Homo sapiens (P27169)
Stevens, R.C.; Suzuki, S.M.; Cole, T.B.; Park, S.S.; Richter, R.J.; Furlong, C.E.
Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning
Proc. Natl. Acad. Sci. USA
105
12780-12784
2008
Homo sapiens (P27169)
Hu, X.; Jiang, X.; Lenz, D.E.; Cerasoli, D.M.; Wallqvist, A.
In silico analyses of substrate interactions with human serum paraoxonase 1
Proteins
75
486-498
2009
Homo sapiens (P27169), Homo sapiens
Richter, R.J.; Jarvik, G.P.; Furlong, C.E.
Paraoxonase 1 (PON1) status and substrate hydrolysis
Toxicol. Appl. Pharmacol.
235
1-9
2009
Homo sapiens (P27169)
Hsu, Y.T.; Su, C.Y.; Du, H.C.; Jao, S.C.; Li, W.S.
Evaluation of organophosphorus chemicals-degrading enzymes: a comparison of Escherichia coli and human cytosolic aminopeptidase P
Chem. Biodivers.
5
1401-1411
2008
Escherichia coli (P15034), Homo sapiens (Q9NQW7)
Nguyen, S.D.; Hung, N.D.; Cheon-Ho, P.; Ree, K.M.; Dai-Eun, S.
Oxidative inactivation of lactonase activity of purified human paraoxonase 1 (PON1)
Biochim. Biophys. Acta
1790
155-160
2009
Homo sapiens
Popa, C.; van Tits, L.J.; Barrera, P.; Lemmers, H.L.; van den Hoogen, F.H.; van Riel, P.L.; Radstake, T.R.; Netea, M.G.; Roest, M.; Stalenhoef, A.F.
Anti-inflammatory therapy with tumour necrosis factor alpha inhibitors improves high-density lipoprotein cholesterol antioxidative capacity in rheumatoid arthritis patients
Ann. Rheum. Dis.
68
868-872
2009
Homo sapiens
Samra, Z.Q.; Shabir, S.; Rehmat, Z.; Zaman, M.; Nazir, A.; Dar, N.; Athar, M.A.
Synthesis of cholesterol-conjugated magnetic nanoparticles for purification of human paraoxonase 1
Appl. Biochem. Biotechnol.
162
671-686
2010
Homo sapiens
Otto, T.C.; Kasten, S.A.; Kovaleva, E.; Liu, Z.; Buchman, G.; Tolosa, M.; Davis, D.; Smith, J.R.; Balcerzak, R.; Lenz, D.E.; Cerasoli, D.M.
Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae
Chem. Biol. Interact.
187
388-392
2010
Homo sapiens
Gencer, N.; Arslan, O.
Purification human PON1Q192 and PON1R192 isoenzymes by hydrophobic interaction chromatography and investigation of the inhibition by metals
J. Chromatogr. B
877
134-140
2009
Homo sapiens
Renault, F.; Carus, T.; Clery-Barraud, C.; Elias, M.; Chabriere, E.; Masson, P.; Rochu, D.
Integrative analytical approach by capillary electrophoresis and kinetics under high pressure optimized for deciphering intrinsic and extrinsic cofactors that modulate activity and stability of human paraoxonase (PON1)
J. Chromatogr. B
878
1346-1355
2010
Homo sapiens, synthetic construct
Ekinci, D.; Beydemir, S.
Effect of some analgesics on paraoxonase-1 purified from human serum
J. Enzyme Inhib. Med. Chem.
24
1034-1039
2009
Homo sapiens
Fairchild, S.Z.; Peterson, M.W.; Hamza, A.; Zhan, C.G.; Cerasoli, D.M.; Chang, W.E.
Computational characterization of how the VX nerve agent binds human serum paraoxonase 1
J. Mol. Model.
17
97-109
2011
Homo sapiens
Camuzcuoglu, H.; Toy, H.; Cakir, H.; Celik, H.; Erel, O.
Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus
J. Womens Health (Larchmt)
18
1435-1439
2009
Homo sapiens
Valiyaveettil, M.; Alamneh, Y.; Biggemann, L.; Soojhawon, I.; Doctor, B.P.; Nambiar, M.P.
Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1
Biochem. Biophys. Res. Commun.
403
97-102
2010
Oryctolagus cuniculus, Homo sapiens
Valiyaveettil, M.; Alamneh, Y.; Rezk, P.; Biggemann, L.; Perkins, M.W.; Sciuto, A.M.; Doctor, B.P.; Nambiar, M.P.
Protective efficacy of catalytic bioscavenger, paraoxonase 1 against sarin and soman exposure in guinea pigs
Biochem. Pharmacol.
81
800-809
2011
Oryctolagus cuniculus, Homo sapiens
Tsai, P.C.; Bigley, A.; Li, Y.; Ghanem, E.; Cadieux, C.L.; Kasten, S.A.; Reeves, T.E.; Cerasoli, D.M.; Raushel, F.M.
Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase
Biochemistry
49
7978-7987
2010
Homo sapiens
Moghtaderi, A.; Hashemi, M.; Dabiri, S.; Moazeni-Roodi, A.; Hosseini, M.
Serum paraoxonase and arylesterase activities in patients with lacunar infarction: a case control study
Clin. Biochem.
44
288-292
2011
Homo sapiens
Hashemi, M.; Kordi-Tamandani, D.M.; Sharifi, N.; Moazeni-Roodi, A.; Kaykhaei, M.A.; Narouie, B.; Torkmanzehi, A.
Serum paraoxonase and arylesterase activities in metabolic syndrome in Zahedan, southeast Iran
Eur. J. Endocrinol.
164
219-222
2011
Homo sapiens
Cayir, K.; Bilici, M.; Tekin, S.; Kara, F.; Turkyilmaz, A.; Yildirim, A.
Serum paraoxonase and arylesterase activities in esophageal cancer: A controlled study
Eur. J. Gen. Med.
7
398-403
2010
Homo sapiens
-
Bayrak, A.; Bayrak, T.; Demirpence, E.; Kilinc, K.
Differential hydrolysis of homocysteine thiolactone by purified human serum (192)Q and (192)R PON1 isoenzymes
J. Chromatogr. B
879
49-55
2011
Homo sapiens
Duygu, F.; Tekin Koruk, S.; Aksoy, N.
Serum paraoxonase and arylesterase activities in various forms of hepatitis B virus infection
J. Clin. Lab. Anal.
25
311-316
2011
Homo sapiens
Kockar, F.; Sinan, S.; Yildirim, H.; Arslan, O.
Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro
J. Enzyme Inhib. Med. Chem.
25
715-719
2010
Homo sapiens
Valiyaveettil, M.; Alamneh, Y.; Biggemann, L.; Soojhawon, I.; Farag, H.A.; Agrawal, P.; Doctor, B.P.; Nambiar, M.P.
In vitro efficacy of paraoxonase 1 from multiple sources against various organophosphates
Toxicol. In Vitro
25
905-913
2011
Oryctolagus cuniculus, Homo sapiens
Trovaslet-Leroy, M.; Musilova, L.; Renault, F.; Brazzolotto, X.; Misik, J.; Novotny, L.; Froment, M.T.; Gillon, E.; Loiodice, M.; Verdier, L.; Masson, P.; Rochu, D.; Jun, D.; Nachon, F.
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents
Toxicol. Lett.
206
14-23
2011
Brevundimonas diminuta, Homo sapiens
Erzengin, M.; Basaran, I.; Cakir, U.; Aybey, A.; Sinan, S.
In vitro inhibition effect of some dihydroxy coumarin compounds on purified human serum paraoxonase 1 (PON1)
Appl. Biochem. Biotechnol.
168
1540-1548
2012
Homo sapiens
Bajaj, P.; Aggarwal, G.; Tripathy, R.K.; Pande, A.H.
Interplay between amino acid residues at positions 192 and 115 in modulating hydrolytic activities of human paraoxonase 1
Biochimie
105
202-210
2014
Homo sapiens (P27169), Homo sapiens
Kirbas, A.; Kirbas, S.; Anlar, O.; Efe, H.; Yilmaz, A.
Serum paraoxonase and arylesterase activity and oxidative status in patients with multiple sclerosis
J. Clin. Neurosci.
20
1106-1109
2013
Homo sapiens
Kirbas, A.; Kirbas, S.; Cure, M.C.; Tufekci, A.
Paraoxonase and arylesterase activity and total oxidative/anti-oxidative status in patients with idiopathic Parkinson's disease
J. Clin. Neurosci.
21
451-455
2014
Homo sapiens
Kati, C.; Karadas, S.; Aslan, M.; Gonullu, H.; Duran, L.; Demir, H.
Serum paraoxonase and arylesterase activities and oxidative stress levels in patients with SSRI intoxication
J. Membr. Biol.
247
17-21
2014
Homo sapiens
Bajaj, P.; Tripathy, R.K.; Aggarwal, G.; Pande, A.H.
Characterization of human paraoxonase 1 variants suggest that His residues at 115 and 134 positions are not always needed for the lactonase/arylesterase activities of the enzyme
Protein Sci.
22
1799-1807
2013
Homo sapiens (P27169), Homo sapiens
Olama, S.M.; Elarman, M.M.
Evaluation of paraoxonase and arylesterase activities in Egyptian patients with ankylosing spondylitis
Rheumatol. Int.
33
1487-1494
2013
Homo sapiens
Tekin Koruk, S.; Aksoy, N.; Hamidanoglu, M.; Karsen, H.; Unlu, S.; Bilinc, H.
The activity of paraoxonase and arylesterase in patients with osteomyelitis
Scand. J. Clin. Lab. Invest.
72
513-517
2012
Homo sapiens
Chambers, J.E.; Chambers, H.W.; Meek, E.C.; Funck, K.E.; Bhavaraju, M.H.; Gwaltney, S.R.; Pringle, R.B.
Novel nucleophiles enhance the human serum paraoxonase 1 (PON1)-mediated detoxication of organophosphates
Toxicol. Sci.
143
46-53
2015
Homo sapiens
Abulimite, Z.; Mu, X.; Xiao, S.; Liu, M.; Li, Q.; Chen, G.
New chemiluminescent substrates of paraoxonase 1 with improved specificity synthesis and properties
Appl. Biochem. Biotechnol.
176
301-316
2015
Homo sapiens (P27169)
Tripathy, R.K.; Aggarwal, G.; Bajaj, P.; Kathuria, D.; Bharatam, P.V.; Pande, A.H.
Towards understanding the catalytic mechanism of human paraoxonase 1 experimental and in silico mutagenesis studies
Appl. Biochem. Biotechnol.
182
1642-1662
2017
Homo sapiens, Homo sapiens (P27169)
Lyagin, I.V.; Andrianova, M.S.; Efremenko, E.N.
Extensive hydrolysis of phosphonates as unexpected behaviour of the known His6-organophosphorus hydrolase
Appl. Microbiol. Biotechnol.
100
5829-5838
2016
Homo sapiens (P27169)
Kul, A.; Uzkeser, H.; Ozturk, N.
Paraoxonase and arylesterase levels in Behcets disease and their relations with the disease activity
Biochem. Genet.
55
335-344
2017
Homo sapiens
Ashani, Y.; Leader, H.; Aggarwal, N.; Silman, I.; Worek, F.; Sussman, J.L.; Goldsmith, M.
Invitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for invivo protection against organophosphate intoxications
Chem. Biol. Interact.
259
252-256
2016
Pseudomonas sp., Brevundimonas diminuta (P0A434), Homo sapiens (P27169), Agrobacterium tumefaciens (Q93LD7)
Ponce-Ruiz, N.; Murillo-Gonzalez, F.E.; Rojas-Garcia, A.E.; Mackness, M.; Bernal-Hernandez, Y.Y.; Barron-Vivanco, B.S.; Gonzalez-Arias, C.A.; Medina-Diaz, I.M.
Transcriptional regulation of human paraoxonase 1 by nuclear receptors
Chem. Biol. Interact.
268
77-84
2017
Homo sapiens (P27169)
Zsiros, N.; Koncsos, P.; Lorincz, H.; Seres, I.; Katko, M.; Szentpeteri, A.; Varga, V.E.; Fueloep, P.; Paragh, G.; Harangi, M.
Paraoxonase-1 arylesterase activity is an independent predictor of myeloperoxidase levels in overweight patients with or without cardiovascular complications
Clin. Biochem.
49
862-867
2016
Homo sapiens
Arulkumar, M.; Vijayan, R.; Penislusshiyan, S.; Sathishkumar, P.; Angayarkanni, J.; Palvannan, T.
Alteration of paraoxonase, arylesterase and lactonase activities in people around fluoride endemic area of Tamil Nadu, India
Clin. Chim. Acta
471
206-215
2017
Homo sapiens
Millenson, M.E.; Braun, J.M.; Calafat, A.M.; Barr, D.B.; Huang, Y.T.; Chen, A.; Lanphear, B.P.; Yolton, K.
Urinary organophosphate insecticide metabolite concentrations during pregnancy and childrens interpersonal, communication, repetitive, and stereotypic behaviors at 8 years of age the home study
Environ. Res.
157
9-16
2017
Homo sapiens (P27169)
Bizon, A.; Milnerowicz, H.
The effect of divalent metal chelators and cadmium on serum phosphotriesterase, lactonase and arylesterase activities of paraoxonase 1
Environ. Toxicol. Pharmacol.
58
77-83
2018
Homo sapiens
Kahveci, H.; Laloglu, F.; Kilic, O.; Ciftel, M.; Yildirim, A.; Orbak, Z.; Ertekin, V.; Laloglu, E.
Serum paraoxonase and arylesterase values as antioxidants in healthy premature infants at fasting and posprandial times
Eur. Rev. Med. Pharmacol. Sci.
19
1761-1765
2015
Homo sapiens
Cebi, A.; Akgun, E.; Esen, R.; Demir, H.; Cifci, A.
The activities of serum paraoxonase and arylesterase and lipid profile in acute myeloid leukemia preliminary results
Eur. Rev. Med. Pharmacol. Sci.
19
4590-4594
2015
Homo sapiens
Zargari, M.; Sharafeddin, F.; Mahrooz, A.; Alizadeh, A.; Masoumi, P.
The common variant Q192R at the paraoxonase 1 (PON1) gene and its activity are responsible for a portion of the altered antioxidant status in type 2 diabetes
Exp. Biol. Med.
241
1489-1496
2016
Homo sapiens
Perla-Kajan, J.; Borowczyk, K.; Glowacki, R.; Nygard, O.; Jakubowski, H.
Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans
FASEB J.
32
6019
2018
Homo sapiens
Aggarwal, G.; Prajapati, R.; Tripathy, R.K.; Bajaj, P.; Iyengar, A.R.; Sangamwar, A.T.; Pande, A.H.
Toward understanding the catalytic mechanism of human paraoxonase 1 site-specific mutagenesis at position 192
PLoS ONE
11
e0147999
2016
Homo sapiens (P27169), Homo sapiens
Bajaj, P.; Tripathy, R.K.; Aggarwal, G.; Pande, A.H.
Expression and purification of biologically active recombinant human paraoxonase 1 from inclusion bodies of Escherichia coli
Protein Expr. Purif.
115
95-101
2015
Homo sapiens (P27169), Homo sapiens
Yun, H.; Yu, J.; Kim, S.; Lee, N.; Lee, J.; Lee, S.; Kim, N.D.; Yu, C.; Rho, J.
Expression and purification of biologically active recombinant human paraoxonase 1 from a Drosophila S2 stable cell line
Protein Expr. Purif.
131
34-41
2017
Homo sapiens (P27169)
Korkmaz, H.; Tabur, S.; Ozkaya, M.; Oguz, E.; Elboga, U.; Aksoy, N.; Akarsu, E.
Paraoxonase and arylesterase levels in autoimmune thyroid diseases
Redox Rep.
21
227-231
2016
Homo sapiens
