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Literature summary for 3.1.8.1 extracted from

  • Richter, R.J.; Jarvik, G.P.; Furlong, C.E.
    Paraoxonase 1 (PON1) status and substrate hydrolysis (2009), Toxicol. Appl. Pharmacol., 235, 1-9.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
Q192R the mutant hydrolyzes paraoxon approximately 9times as efficiently as the wild type enzyme and is significantly more efficient in hydrolyzing chlorpyrifos oxon Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27169
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chlorpyrifos-oxon + H2O
-
Homo sapiens 3,5,6-trichloro-2-pyridinol + diethyl phosphate
-
?
diazoxon + H2O
-
Homo sapiens 2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate
-
?
paraoxon + H2O
-
Homo sapiens diethylphosphate + 4-nitrophenol
-
?

Synonyms

Synonyms Comment Organism
paraoxonase 1
-
Homo sapiens
PON1
-
Homo sapiens