Application | Comment | Organism |
---|---|---|
medicine | diminished paraoxonase and arylesterase activity is associated with particular stage, grade and CA-125 level of ovarian cancer | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27169 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | the enzyme is synthesized in the liver | Homo sapiens | - |
serum | the enzyme is secreted into the serum | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PON1 plays a key role in the protection of low density lipoproteins and high density lipoproteins from oxidation by hydrolyzing activated phospholipids and lipid peroxide products | Homo sapiens | ? | - |
? | |
paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
paraoxonase-1 | - |
Homo sapiens |
PON1 | PON1 is an high density lipoprotein-associated enzyme with three activities: paraoxonase, arylesterase and dyazoxonase | Homo sapiens |